Rogers An Introduction to Mechanisms in Pharmacology and Therapeutics

1. Auflage 2013
ISBN: 978-1-4831-9551-3
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 420 Seiten, Web PDF

An Introduction to Mechanisms in Pharmacology and Therapeutics aims to provide some extra information and background reading on modes of action of drugs, but it is not meant to replace existing pharmacology textbooks. It also attempts to show the connection between cell biology and the practice of clinical medicine. This book is organized into 13 chapters that discuss drug-receptor interactions and the influence of drugs on the nervous, respiratory, circulatory, and alimentary systems. They also explain the concepts of pharmacogenetics, intracellular control mechanisms, chemotherapy, and the different types of drugs. This book will be of interest to preclinical and clinical medical students and those preparing for Bachelor of Science degree in Pharmacology and others interested in understanding how drugs work.

Autoren/Hrsg.

Rogers, Howard

Inhaltsverzeichnis

1;Front Cover;1
2;An Introduction to Mechanisms in Pharmacology and Therapeutics;4
3;Copyright Page
;5
4;Table of Contents;6
5;Preface;8
6;Chapter 1. The Cell and Drugs;10
6.1;SUMMARY;13
6.2;REFERENCES;14
7;Chapter 2. Drug-Receptor Interactions;15
7.1;FORCES BINDING THE DRUG TO THE RECEPTOR;17
7.2;THE MATHEMATICAL ANALYSIS OF DRUG-RECEPTOR COMBINATION;26
7.3;THE EFFECT OF DRUG BINDING ON THE RECEPTOR;39
7.4;REFERENCES;47
8;Chapter 3. Cell Membranes;49
8.1;PHYSICAL EFFECTS OF DRUGS ON MEMBRANES;57
8.2;REFERENCES;59
9;Chapter 4. Drugs and Intracellular Control Mechanisms;60
9.1;(a) CALCIUM AND EXCITATION-RESPONSE COUPLING;60
9.2;(b) CHEMICAL CONTROL OF TRANSMITTER RELEASE AND ACTIVITY;68
9.3;(c) DRUGS WHICH AFFECT THE CONTROL OF BLOOD GLUCOSE;77
9.4;(d) BLOOD LIPID LOWERING AGENTS;89
9.5;(e) THE INFLUENCE OF DRUGS ON FOLATE METABOLISM;94
9.6;REFERENCES;99
10;Chapter 5. The Fate of Drugs in the Body;101
10.1;PROTEIN BINDING;103
10.2;"METABOLIC HALF-LIFE";104
10.3;METABOLIC CONVERSIONS;105
10.4;CONJUGATION REACTIONS;111
10.5;FACTORS WHICH MODIFY DRUG METABOLISM;115
10.6;DRUG EXCRETION;117
10.7;REFERENCES;118
11;Chapter 6. Pharmacogenetics;119
11.1;FREQUENTLY OCCURRING CONDITIONS;119
11.2;RARE CONDITIONS;124
11.3;OTHER FACTORS PRODUCING VARIABILITY IN DRUG RESPONSE;126
11.4;REFERENCES;126
12;Chapter 7. The Nervous System;127
12.1;ACETYLCHOLINE;130
12.2;THE ADRENERGIC NERVOUS SYSTEM;137
12.3;THE NEUROMUSCULAR JUNCTION;153
12.4;ANAESTHETICS;155
12.5;LOCAL ANAESTHETICS;162
12.6;HYPNOTICS;164
12.7;ANXIOLYTIC DRUGS;172
12.8;ANTIDEPRESSANT DRUGS;174
12.9;THE MAJOR TRANQUILLISERS;180
12.10;ANTICONVULSANTS;186
12.11;ANTI-PARKINSONIAN DRUGS;190
12.12;DRUG-INDUCED PARKINSONISM;192
12.13;THE NARCOTIC ANALGESICS;192
12.14;ALCOHOL;199
12.15;MIGRAINE;203
12.16;REFERENCES;207
13;Chapter 8. Anti-inflammatory Analgesics; Gout Antihistamines; Immunosuppressive Drugs;209
13.1;ANTI-INFLAMMATORY ANALGESICS (MINOR ANALGESICS);209
13.2;GOUT;213
13.3;HISTAMINE;214
13.4;SOME MECHANISMS OF ACTION OF IMMUNOSUPPRESSIVE DRUGS;217
13.5;IMMUNOSUPPRESSIVE DRUGS;219
13.6;REFERENCES;223
14;Chapter 9. Circulatory System;224
14.1;ANTIARRHYTHMIC DRUGS;224
14.2;AUTONOMIC CONTROL OF THE HEART
;241
14.3;VASOACTIVE DRUGS;245
14.4;VASODILATOR DRUGS;249
14.5;THE CONTROL OF BLOOD PRESSURE;251
14.6;ANTI-ANGINAL DRUGS;266
14.7;CARDIAC GLYCOSIDES;272
14.8;REFERENCES;282
15;Chapter 10. Drugs acting on the Respiratory System;284
15.1;CHEMICAL CONTROL OF RESPIRATION;284
15.2;AIRWAYS OBSTRUCTION;291
15.3;COUGH;309
15.4;REFERENCES;314
16;Chapter 11. The Diuretic Drugs;315
16.1;THE NORMAL NEPHRON;315
16.2;METHODS OF DETERMINING SITES OF ACTION OF DIURETICS;316
16.3;GROUPS OF DIURETICS;318
16.4;POTASSIUM DEPLETION;325
16.5;THE USE OF DIURETICS;326
16.6;REFERENCES;327
17;Chapter 12. The Alimentary System;328
17.1;APPETITE DEPRESSANT DRUGS;328
17.2;DRUGS USED IN THE TREATMENT OF OESOPHAGEAL DISORDERS;330
17.3;ANTIEMETICS;331
17.4;5-HYDROXYTRYPTAMINE (5-HT);334
17.5;THE CONTROL OF GASTRIC SECRETION AND PEPTIC ULCERATION;337
17.6;DRUGS USED TO CONTROL DIARRHOEA;351
17.7;LAXATIVES AND PURGATIVES;353
17.8;THE LIVER AND BILIARY APPARATUS;355
17.9;GALLSTONES;359
17.10;REFERENCES;361
18;Chapter 13. Chemotherapy;362
18.1;ANTIBACTERIAL DRUGS;362
18.2;ANTIVIRAL CHEMOTHERAPY;382
18.3;ANTIMALARIALS;384
18.4;LEISHMANIASIS AND SCHISTOSOMIASIS;387
18.5;TRYPANOSOMIASIS;389
18.6;FILARIASIS;389
18.7;AMOEBIASIS;390
18.8;ANTHELMINTICS;390
18.9;ANTITUMOUR DRUGS;391
18.10;STRATEGY OF THE USE OF ANTICANCER DRUGS;400
18.11;REFERENCES;404
19;Index;405