Buch, Englisch, 267 Seiten, HC runder Rücken kaschiert, Format (B × H): 160 mm x 241 mm, Gewicht: 612 g
From Magic, via Miracle, to Memory
Buch, Englisch, 267 Seiten, HC runder Rücken kaschiert, Format (B × H): 160 mm x 241 mm, Gewicht: 612 g
ISBN: 978-94-024-1190-4
Verlag: Springer Netherlands
Investigations into Calabar beans (the dried ripe seeds of Physostigma venenosum) and their alkaloidal components compose a classical scientific journey throughout some one-and-a-half centuries and not only represent a fascinating aspect of the history of medicine but which is, moreover, still ongoing at the forefront of chemical and medical discovery. Those in particular involving its major such component, l-physostigmine, have led to an understanding of some of the fundamental mechanisms occurring in physiology, pharmacology and biochemistry and, either actually or potentially (by providing a template and thereby acting as a “lead compound”) have provided a useful treatment for a variety of neurological disorders associated with irregularities in cholinergic transmission in which augmentation of cholinergic activity has proved to be beneficial.
Zielgruppe
Research
Autoren/Hrsg.
Fachgebiete
- Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)
- Naturwissenschaften Biowissenschaften Botanik
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Pharmazie
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
- Naturwissenschaften Chemie Organische Chemie
Weitere Infos & Material
Chronology.- Abbreviations.- Preface and acknowledgements.- 1. Introduction.- 2. l-Physostigmine (eserine).- 3. l-Physovenine.- 4. l-Eseramine.- 5. l-N-Norphysostigmine.- 6. l-Geneserine.- 7. H-, C- and N-Nuclear magnetic resonance spectra of the alkaloids of the Calabar bean.- 8. Other alkaloids of, as yet, unknown structures that have been isolated, or allegedly so, from the Calabar bean.- 9. Non-alkaloidal components of the Calabar bean.- 10. Biological activities of the alkaloids of the Calabar bean.- 11. Notes.- 12. References.- 13. Index.
