Gene Therapy in Inflammatory Diseases

Erscheinungsjahr 2012
ISBN: 978-3-0348-9584-2
Verlag: Birkhäuser

Buch, Englisch, 260 Seiten, Format (B × H): 155 mm x 235 mm, Gewicht: 423 g

Reihe: Progress in Inflammation Research

Gene therapy for inflammatory diseases is a new, burgeoning field of

medicine. Edited by the undisputed pioneers of this area of research,

this volume is the first devoted to its topic. It contains thirteen

chapters, each written by leaders in their respective fields, that

summarize the state of the art in developing novel, gene based

treatments for inflammatory diseases. As well as providing an

introduction to the basic concepts of gene therapy and the use of naked

DNA approaches, the book describes the advances that have been made in

applying them to arthritis, lupus, multiple sclerosis, diabetes,

Sjogren`s syndrome and transplantation.One chapter is devoted to

discussing the first human clinical trials that apply gene therapy to

the treatment of an inflammatory disease. As well as providing novel

therapeutic approaches, gene therapy facilitates the development of new

and improved animal models of disease; a chapter describing these

advances is also included. As an up-to-date, timely book written by th

Zielgruppe

Professional/practitioner

Autoren/Hrsg.

Evans, Christopher H.

Robbins, Paul D.

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Rheumatologie, Muskelerkrankungen
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Humangenetik
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Chirurgie Orthopädie- und Unfallchirurgie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Biomedizin, Medizinische Forschung, Klinische Studien

Inhaltsverzeichnis

Gene therapy for inflammatory diseases - basic concepts.- Gene therapy for rheumatoid arthritis: preclinical studies.- Cartilage erosion in rheumatoid arthritis: studies in SCID mouse model.- Gene therapy for rheumatoid arthritis: clinical studies.- Cytokine gene therapy of allergic airways inflammation.- Gene therapy for inflammatory diseases of the salivary glands.- Gene therapy for management of lupus: correction of Fas and Fas ligand-induced apoptosis in murine disease - therapeutic rationale and strategies.- Gene therapy for multiple sclerosis.- Gene therapy for type I diabetes mellitus.- Gene transfer to facilitate transplantation.- DNA vaccination as an anti-inflammatory strategy.- Naked DNA as a gene delivery vehicle in inflammatory diseases.- Animal models of arthritis generated by gene transfer.