Advances in Medicinal Chemistry

Erscheinungsjahr 1999
ISBN: 978-0-7623-0593-3
Verlag: Elsevier Science & Technology

Buch, Englisch, 200 Seiten, Format (B × H): 156 mm x 234 mm, Gewicht: 460 g

Volume 5 of Advances in Medicinal Chemistry contains four intriguing and detailed accounts of the close interface between synthetic chemistry, structure-activity relationships, biochemistry, and pharmacology. In Chapter 1, there is a comprehensive survey of the immunophilin area specifically focussing on neuroregenerative applications in the central nervous system. In Chapter 2, there is an overview of the development of a potent analgesic compound that works via modulation of neuronal nicotinic acetylcholine receptors. In Chapter 3, there is a description of dopamine D-2 autoreceptor partial agonists as potential therapy for the treatment of schizophrenia. In Chapter 4, there is a summary of the successful program in which potent non-peptide inhibitors of HIV protease from the AIDS virus were developed.

Autoren/Hrsg.

Reitz, A.B.

Dax, S.L.

Fachgebiete

• Naturwissenschaften Biowissenschaften Proteinforschung
• Naturwissenschaften Chemie Organische Chemie Supramolekularchemie
• Naturwissenschaften Biowissenschaften Zellbiologie
• Naturwissenschaften Biowissenschaften Molekularbiologie

Inhaltsverzeichnis

Preface. Immunophilins: the next generation. Discovery of ABT-594 and related neuronal nicotinic acetylcholine receptor modulators as analgesic agents: medicinal chemistry and biology. Discovery and preclinical evaluation of novel dopamine partial agonists as antipsychotic agents. Nonpeptide inhibitors of HIV protease.