Reitz / Dax Advances in Medicinal Chemistry

1. Auflage 1999
ISBN: 978-0-08-052677-5
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 200 Seiten, Web PDF

Volume 5 of Advances in Medicinal Chemistry contains four intriguing and detailed accounts of the close interface between synthetic chemistry, structure-activity relationships, biochemistry, and pharmacology. In Chapter 1, there is a comprehensive survey of the immunophilin area specifically focussing on neuroregenerative applications in the central nervous system. In Chapter 2, there is an overview of the development of a potent analgesic compound that works via modulation of neuronal nicotinic acetylcholine receptors. In Chapter 3, there is a description of dopamine D-2 autoreceptor partial agonists as potential therapy for the treatment of schizophrenia. In Chapter 4, there is a summary of the successful program in which potent non-peptide inhibitors of HIV protease from the AIDS virus were developed.

Autoren/Hrsg.

Reitz, A. B.

Dax, S. L.

Inhaltsverzeichnis

1;Cover;1
2;Copyright Page;5
3;CONTENTS;6
4;LIST OF CONTRIBUTORS;8
5;PREFACE;10
6;CHAPTER 1. IMMUNOPHILINS: THE NEXT GENERATION;12
7;CHAPTER 2. DISCOVERY OF ABT-594 AND RELATED NEURONAL NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS AS ANALGESIC AGENTS: MEDICINAL CHEMISTRY AND BIOLOGY;96
8;CHAPTER 3. DISCOVERY AND PRECLINICAL EVALUATION OF NOVEL DOPAMINE PARTIAL AGONISTS AS ANTIPSYCHOTIC AGENTS;126
9;CHAPTER 4. NONPEPTIDE INHIBITORS OF HIV PROTEASE;170
10;INDEX;208