Reith Neurotransmitter Transporters

Structure, Function, and Regulation
Erscheinungsjahr 1996
ISBN: 978-1-59259-470-2
Verlag: Humana Press
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 405 Seiten, eBook

Reihe: Contemporary Neuroscience

A comprehensive survey of recent advances made in characterizing neurotransmitter transporters-including their imaging in the living brain-and in elucidating the processes underlying biological transport. The expert contributors present up-to-date findings on the molecular cloning of transporters and on neurotransmitter families both in plasma membranes and in storage vesicles. They also provide essential information on the structure-activity relationships for a multitude of recently synthesized dopamine uptake blockers, on transporter changes in the context of human drug abuse, and on the role of transporters in the action of uptake blockers in vivo. The book opens the new frontier of transporters research, authoritatively presenting new insights into their roles in such diseases as brain ischemia and ALS, and into their involvement as targets for antidepressants, antiepileptics, drugs of abuse, and neurotoxins.

Zielgruppe

Professional/practitioner

Autoren/Hrsg.

Reith, Maarten E. A.

Inhaltsverzeichnis

1 • The Structure and Function of Norepinephrine, Dopamine, and Serotonin Transporters.- 2 • Regulation of Antidepressant-Sensitive Serotonin Transporters.- 3 • Mechanisms of Biogenic Amine Neurotransmitter Transporters.- 4 • Cloned Sodium- (and Chloride-) Dependent High-Affinity Transporters for GABA, Glycine, Proline, Betaine, Taurine, and Creatine.- 5 • Sodium-Coupled GABA and Glutamate Transporters: Structure and Function.- 6 • The High-Affinity Glutamate Transporter Family: Structure, Function, and Physiological Relevance.- 7 • Vesicular Neurotransmitter Transporters: Pharmacology, Biochemistry, and Molecular Analysis.- 8 • Neurotransmitter Transporter Proteins: Posttranslational Modifications.- 9 • Dopamine Transporter Uptake Blockers: Structure-Activity Relationships.- 10 • Imaging Transporters for Dopamine and Other Neurotransmitters in Brain.- 11 • The Dopamine Transporter in Human Brain: Characterization and Effect of Cocaine Exposure.- 12 • Role of Axonal and Somatodendritic Monoamine Transporters in Action of Uptake Blockers.