Read / Sussman Evolving Methods for Macromolecular Crystallography

The Structural Path to the Understanding of the Mechanisms of Action of CBRN Agents
1. Auflage 2008
ISBN: 978-1-4020-6316-9
Verlag: Springer Netherlands
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band 245, 192 Seiten

Reihe: NATO Science Series II: Mathematics, Physics and Chemistry

X-ray crystallography is the pre-eminent technique for visualizing the structures of macromolecules at atomic resolution. These structures are central to understanding the detailed mechanisms of biological processes and to discovering novel therapeutics using a structure-based approach. Currently, structures are known for only a small fraction of the proteins encoded by human and pathogenic genomes. To counter the myriad modern threats of disease, there is an urgent need to determine the structures of the thousands of proteins whose structure and function remain unknown.

Zielgruppe

Crystallographers, graduate students, post-doctoral fellows

Autoren/Hrsg.

Read, Randy J.

Sussman, Joel L.

Fachgebiete

• Naturwissenschaften Biowissenschaften Biowissenschaften
• Naturwissenschaften Biowissenschaften Angewandte Biologie Bioinformatik
• Mathematik | Informatik EDV | Informatik Angewandte Informatik Computeranwendungen in Wissenschaft & Technologie
• Technische Wissenschaften Technik Allgemein Computeranwendungen in der Technik
• Naturwissenschaften Physik Thermodynamik Festkörperphysik, Kondensierte Materie
• Naturwissenschaften Chemie Physikalische Chemie Chemische Kristallographie
• Naturwissenschaften Physik Angewandte Physik Biophysik
• Naturwissenschaften Biowissenschaften Angewandte Biologie Biophysik
• Mathematik | Informatik EDV | Informatik Angewandte Informatik Bioinformatik

Über Autor(innen)

Randy J. Read, University of Cambridge, UK / Joel L. Sussman, Weizmann Institute of Science, Rehovot, Israel