Therapeutic Applications of Nitric Oxide in Cancer and Inflammatory Disorders

Third International Conference on Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders
Erscheinungsjahr 2024
ISBN: 978-0-443-22354-9
Verlag: Elsevier Science

Buch, Englisch, 356 Seiten, Format (B × H): 188 mm x 234 mm, Gewicht: 717 g

Therapeutic Applications of Nitric Oxide in Cancer and Inflammatory Disorders: Third International Conference on Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders presents updated information on the chemistry, signaling of newly derived therapeutic nitric oxide donors/inhibitors, and their complexes in liposomes or nanospheres in both preclinical and clinical investigations.

This book consists of the following: The program and abstracts presented at the Third International Conference in Udine, Italy, September 3-5, 2023; Parts I-V review on (I) the general properties of nitric oxide in diseases; (II) the role of nitric oxide in cancer; (III) nitric oxide and immunity; (IV) nitric oxide and aging; and (V) nitric oxide and therapeutics. In addition, part VI is an educational review on artificial intelligence and its application in diseases. These updated reviews present many examples of research investigations related to the application of novel therapeutic compounds on nitric oxide and new derivatives, as well as their significant therapeutic activities against various resistant cancers that are unresponsive to current treatments and in different inflammatory disorders.

This book is a valuable resource for cancer researchers, oncologists, graduate students, and investigators from medical and biomedical fields who want to learn more about NO and its therapeutic applications in cancer and inflammatory diseases. This book is also highly useful for both clinicians and oncologists as well as pharmaceutical companies involved in the development of new anticancer/antiinflammatory agents.

Autoren/Hrsg.

Rapozzi, Valentina

Xodo, Luigi

Bonavida, Benjamin

Fachgebiete

• Wirtschaftswissenschaften Betriebswirtschaft Unternehmensforschung
• Mathematik | Informatik EDV | Informatik Business Application Unternehmenssoftware

Inhaltsverzeichnis

Contributors

About the editors

Preface

UDINE 2023

Objective of this volume

Highlights

I General introduction

1. Nitric oxide pathophysiology and applications in patients undergoing major cardiac surgery
Signori Davide, Mattias Carlström, Lorenzo Berra, and Rezoagli Emanuele

Abbreviations

Introduction

Pathophysiology of CSA-AKI and NO dysregulation

Renal vasoconstriction

Direct free-hemoglobin and catalytic iron injury

Ischemiaereperfusion injury

Conclusions

Conflict of interest statement

Acknowledgments

References

II Nitric oxide and cancer

2. The emerging role of dimethylarginine dimethylaminohydrolase 2 in regulating vasculogenic mimicry in cancer
Arduino A. Mangoni, Lashika Weerakoon, Vinitha N. Ragavan, Natalia Jarzebska, Roman N. Rodionov, and Sara Tommasi

Abbreviations

Introduction

Vasculogenic mimicry: Pathogenesis and clinical significance

Dimethylarginine dimethylaminohydrolase 1: Biology and role in vasculogenic mimicry

Recent developments in understanding the biological role of DDAH2 and its possible effects in vasculogenic mimicry

General considerations

Conflict of interest statement

References

III Nitric oxide reactions in the cells and models to check its biological properties

3. Decoding S-nitrosylation: Theoretical aspects and analytical approaches
Gianmarco Matrullo, Chiara Pecorari, and Giuseppe Filomeni

Abbreviations

Introduction

NO signaling

Nitric oxide in physiology and pathology

S-nitrosylation detection: Approaches and challenges

Conclusion

Conflict of interest

Acknowledgments

References

4. Preclinical models to assess the pharmacological properties of NO derivatives
Lucia Morbidelli and Valerio Ciccone

Abbreviations

From preclinical to clinical trials of drugs

Cell-based in vitro pharmacological screening and safety assessment

Ex vivo experiments

In vivo experiments to assess efficacy and safety of NO derivatives

Conclusions

Acknowledgements

References

IV
Nitric oxide and neurodegeneration

5. Nitric oxide-mediated neuroinflammatory pathways as treatment targets in neurodegeneration
Jennifer Cale, Tracy D. Farr, Sebastien Serres, and Joern R. Steinert

Abbreviations

Introduction

Neurovascular oxidative and nitrergic stress

Redox stress in the vascular, neuronal, and astrocytic compartments

Therapeutic targets of NO signaling

Conclusions

Acknowledgments

References

V Nitric oxide and therapeutics

6. Role of nitric oxide in gemcitabine resistance in pancreatic cancer cells
Mariachiara Gani, Eros Di Giorgio, Raffaella Picco, Luigi E. Xodo, and Valentina Rapozzi

Abbreviations

Introduction

Acknowledgments

References

Further reading

7. Exploring the dual role of nitric oxide in glioblastoma: Therapeutic implications
Inesa Navasardyan and Benjamin Bonavida

Abbreviations

Introduction

Treatment of GBM

NO production and its biological process

Role of the INOS/NO pathway in GBM

NO-targeted therapies in GBM

Discussion

Perspectives and future directions

Acknowledgments

References

8. Nitric oxide donating systems and their potential in shaping tumor immunoregulation
Greta Varchi

Introduction

The tumor microenvironment

The enigmatic dual nature of nitric oxide in cancer

Nitric oxide donors

Nitric oxide donors and the immune system

Conclusions and future directions

References

9. Control of nitric oxide synthase 2: Role of NRF2-regulated distal enhancer
Eros Di Giorgio, Valentina Rapozzi, and Luigi E. Xodo

Abbreviations

Introduction

NOS2 structure and function

NOS2 and cancer

Transcription factors activating NOS2 expression

NRF2 controls the expression of NOS2

RF2 binds to a distal enhancer of NOS2

PDAC-spheroids formation depends on NOS2: Therapeutic implications

Concluding remarks

Conflict of interest

References

Further Reading

10. Nitric oxide in tumor biology: From stemness to metabolic reprogramming
Antonio Rodríguez-Ariza

Abbreviations
Introduction
Role of NO in the acquisition of stem characteristics and therapy resistance in breast cancer
Role of NO in the biology of intestinal cancer cells
Metabolic shift underlies tumor progression and immune evasion in S-nitrosoglutathione reductase-deficient cancer
Conclusions
Acknowledgments
References

11. Impact of nitric oxide on hemeprotein maturation and its relevance to cancer and pulmonary diseases
Chaitali Ghosh, Mamta Sumi, and Arnab Ghosh

Abbreviations
Introduction

Impact of NO on hemeprotein maturation
NO in cancer
Significance of the NO-sGC-cGMP pathway in globin maturation and relevance to cancer progression
NO in asthma and pulmonary diseases
Conclusion and future directions
Acknowledgments
References

VI Educational session

12. Using artificial intelligence to discover new cancer therapies
Apostolos Zaravinos

Index 000

Über Autor(innen)

Xodo, Luigi
Luigi Xodo is a Full Professor of Biochemistry at the Department of Medicine of the University of Udine, Italy. His work focuses on unraveling the oncogenes involved in carcinogenesis and on the development of new cancer therapies. In particular, Dr. Xodo's work led to the discovery that the KRAS oncogene, a key player in cellular transformation toward malignancy, is intricately regulated by guanine-rich sequences that adopt unique G-quadruplex structures. This discovery paved the way for targeted interventions against KRAS-related cancers. Dr. Xodo developed effective anticancer drugs that could inhibit the KRAS oncogene. One notable approach has been the use of cationic porphyrins that specifically target G-quadruplexes in KRAS mRNA and trigger transcript degradation upon photoactivation. In addition, Dr. Xodo's studies contribute to the discovery of a metabolic reprogramming phenomenon in KRAS-related cancers by elucidating how arginine metabolism shifts to promote the production of polyamines, phosphocreatine, and nitric oxide. He is the author of 120 publications in high-quality peer-reviewed journals. His academic contributions are evidenced by 120 publications in peer-reviewed journals with high-impact factor, underlining his profound impact on the field of biochemistry and oncology.