Amorphous Drugs

Benefits and Challenges
Softcover Nachdruck of the original 1. Auflage 2018
ISBN: 978-3-319-89129-3
Verlag: Springer International Publishing

Buch, Englisch, 230 Seiten, Paperback, Format (B × H): 155 mm x 235 mm, Gewicht: 371 g

This book explains theoretical and technological aspects of amorphous drug formulations. It is intended for all those wishing to increase their knowledge in the field of amorphous pharmaceuticals. Conversion of crystalline material into the amorphous state, as described in this book, is a way to overcome limited water solubility of drug formulations, in this way enhancing the chemical activity and bioavailability inside the body.

Written by experts from various fields and backgrounds, the book introduces to fundamental physical aspects (explaining differences between the ordered and the disordered solid states, the enhancement of solubility resulting from drugs amorphization, physical instability and how it can be overcome) as well as preparation and formulation procedures to produce and stabilize amorphous pharmaceuticals. Readers will thus gain a well-funded understanding and find a multi-faceted discussion of the properties and advantages of amorphous drugs and of the challenges in producing and stabilizing them. The book is an ideal source of information for researchers and students as well as professionals engaged in research and development of amorphous pharmaceutical products.

Zielgruppe

Research

Autoren/Hrsg.

Rams-Baron, Marzena

Jachowicz, Renata

Paluch, Marian

Boldyreva, Elena

Zhou, Deliang

Jamroz, Witold

Fachgebiete

• Technische Wissenschaften Maschinenbau | Werkstoffkunde Technische Mechanik | Werkstoffkunde Materialwissenschaft: Keramik, Glas, Sonstige Werkstoffe
• Naturwissenschaften Physik Thermodynamik Physik der Zustandsübergänge
• Naturwissenschaften Chemie Chemie Allgemein Pharmazeutische Chemie, Medizinische Chemie
• Technische Wissenschaften Sonstige Technologien | Angewandte Technik Medizintechnik, Biomedizintechnik
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Medizintechnik, Biomedizintechnik, Medizinische Werkstoffe
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Pharmazie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Pharmazeutische Technologie

Inhaltsverzeichnis

Why amorphous drugs?.- Order vs. disorder in the solid state.- Amorphous drug solubility and absorption enhancement.- Amorphous drug preparation methods.- Physical instability - a key problem of amorphous drugs.- Amorphous drug formulation.

Über Autor(innen)

Dr. Marzena Rams-Baron holds an assistant professor position in the Department of Biophysics and Molecular Physics at University of Silesia in Katowice.

Prof. Dr. Renata Jachowicz is currently head of the Chair and Department of Pharmaceutical Technology and Biopharmaceutics at Jagiellonian University in Cracow. She is a member of Committee on Therapy and Drug Research of the Polish Academy of Science, Head of Subcommittee of Pharmaceutical Technology and Biopharmacy and also Head of the Expert Group of Pharmaceutical Technology and Galens Products of Polish Pharmacopoeia Committee.
Prof. Dr. Elena Boldyreva is a Chief Researcher at the Institute of Solid State Chemistry and Mechanochemistry, Siberian Branch of Russian Academy of Sciences in Novosibirsk and the Head of the Chair of Solid State Chemistry of Novosibirsk State University.


Dr. Deliang Zhou is a principal research pharmaceutical scientist in Drug Products, Operations Science & Technology at AbbVie.

Dr. Witold Jamróz holds an assistant professor position in the Department of Pharmaceutical Technology and Biopharmaceutics at Jagiellonian University in Cracow

Prof. Dr. Marian Paluch is currently the head of the Department of Biophysics and Molecular Physics at University of Silesia in Katowice. Since 2010 he is an academic editor in AIP Advances. He is (co)author of more than 380 publications, a book and several book chapters. His papers were cited more than 7700 times.