Ramanathan Mass Spectrometry in Drug Metabolism and Pharmacokinetics

1. Auflage 2011
ISBN: 978-1-118-21157-1
Verlag: John Wiley & Sons
Format: EPUB
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 408 Seiten, E-Book

This timely reference discusses mass spectrometry in drug metabolism and pharmacokinetic studies. With contributions by professionals from the pharmaceutical industry, this book begins with a review of current mass spectrometry techniques and applications, followed by discussions of various methods for using MS in drug metabolism studies and pharmacokinetics. Highlighting the critical importance of ADME studies for understanding how a drug is absorbed, distributed, metabolized, and excreted by the body, the book s focuses on the use of LC/MS and MALDI-MS. This is a valuable reference for scientists in the pharmaceutical industry, medicine, academia, and even those working in homeland defense.

Autoren/Hrsg.

Ramanathan, Ragu

Inhaltsverzeichnis

Preface vii
About the Editor ix
Contributors xi
1. Evolving Role of Mass Spectrometry in Drug Discovery andDevelopment 1
Dil M. Ramanathan and Richard M. LeLacheur
2. Quantitative Bioanalysis in Drug Discovery and Development:Principles and Applications 87
Ayman El-Kattan, Chris Holliman, and Lucinda H. Cohen
3. Quadrupole, Triple-Quadrupole, and Hybrid Linear Ion TrapMass Spectrometers for Metabolite Analysis 123
Elliott B. Jones
4. Applications of Quadrupole Time-of-Flight Mass Spectrometryin Reactive Metabolite Screening 159
Jose M. Castro-Perez
5. Changing Role of FTMS in Drug Metabolism 191
Petia A. Shipkova, Jonathan L. Josephs, and Mark Sanders
6. High-Resolution LC-MS-Based Mass Defect FilterApproach: Basic Concept and Application in Metabolite Detection223
Haiying Zhang, Donglu Zhang, Mingshe Zhu, and Kenneth L.Ray
7. Applications of High-Sensitivity Mass Spectrometry andRadioactivity Detection Techniques in Drug Metabolism Studies253
Wing W. Lam, Cho-Ming Loi, Angus Nedderman, and DonWalker
8. Online Electrochemical-LC-MS Techniques forProfiling and Characterizing Metabolites and Degradants 275
Paul H. Gamache, David F. Meyer, Michael C. Granger, and Ian N.Acworth
9. LC-MS Methods with Hydrogen/Deuterium Exchange forIdentification of Hydroxylamine, N-Oxide, and Hydroxylated Analogsof Desloratadine 295
Natalia A. Penner, Joanna Zgoda-Pols, Ragu Ramanathan, Swapan K.Chowdhury, and Kevin B. Alton
10. Turbulent-Flow LC-MS: Applications for AcceleratingPharmacokinetic Profiling and Metabolite Identification 311
Joseph L. Herman and Joseph M. Di Bussolo
11. Desorption Ionization Techniques for Quantitative Analysisof Drug Molecules 341
Jason S. Gobey, John Janiszewski, and Mark J. Cole
12. MALDI Imaging Mass Spectrometry for Direct Tissue Analysisof Pharmaceuticals 359
Yunsheng Hsieh and Walter A. Korfmacher
Index 383

Über Autor(innen)

Ragu Ramanathan received a B.Sc. in Chemistry from the University of Southern Mississippi and a Ph.D. in Physical Chemistry/Mass Spectrometry from the University of Florida. His graduate research focused on coupling of electrospray ionization (ESI) to Fourier transform ion cyclotron resonance (FTICR) mass spectrometer. After spending three years as a postdoctoral research fellow with Professor Michael L. Gross at the Washington University, St. Louis, Missouri, Dr. Ramanathan managed the Center for Advanced Mass Spectrometry at the Analytical Bio-Chemistry Laboratories, Columbia, Missouri. In 1998, Dr. Ramanathan joined Schering-Plough Research Institute's (SPRI) Drug Metabolism and Pharmacokinetics (DMPK) Department and completed his tenure as a senior principal scientist in 2008. While at SPRI, Dr. Ramanathan was involved in the application of LC-MS for profiling and characterization of metabolites of drug candidates in the preclinical development and clinical stages. Dr. Ramanathan was with Pfizer Global Research and Development from 1999 to 2002 as a group leader of the Ann Arbor site biotransformation group. Dr. Ramanathan is currently an associate director at the Bristol-Myers Squibb, Co. and is responsible for elucidating biotransformation pathways of development drug candidates. Dr. Ramanathan's accomplishments include 35 peer-reviewed papers, 10 book chapters, and over 60 oral/poster presentations. He also served as a chairperson for the North Jersey ACS Mass Spectrometry Discussion Group and as a chairman for DMPK sessions of the American Society for Mass Spectrometry and Eastern Analytical Symposium meetings.