Quesniaux / Ryffel / Di Padova Th 17 Cells: Role in Inflammation and Autoimmune Disease

1. Auflage 2009
ISBN: 978-3-7643-8681-8
Verlag: Springer
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 244 Seiten, eBook

Reihe: Progress in Inflammation Research

The IL-17 cytokines represent a novel family of cytokines, which defines a new effector T cell, the Th17 cell, and extend the Th1-Th2 paradigm. Th17 cells in part co-express at least IL-17A and IL-17F, IL-21 and IL-22. IL-17 A/F are produced by T cells ( and ), iNKT cells, and possibly neutrophils, dendritic cells and Paneth cells. The regulation of IL-17 family member’s expression, and the identification of effector mechanisms are an area of intense current research. Recognized regulators of IL-17A expression include the nuclear receptor ROR t, proinflammatory cyt- ines such as IL-1, IL-6 with TGF- , IL-21, IL-23 IL-25 in the absence of IFN- and IL-4, which are discussed. Recent data suggest that IL-17A may have a dual fu- tion – pro-inflammatory and anti-inflammatory- suggesting that IL-17A may also contribute to terminate inflammation. Further, a reciprocal regulation of Th17 and regulatory T cells including the role of retinoic acid and TGF- is discussed. The discovery that patients with rheumatoid arthritis, allergic disorders, psor- sis and inflammatory bowel disease express IL-17A generated interest in the medical community and instigated a flurry of experimental research on the potential role of Th17 in inflammatory diseases. Experimental studies confirmed that IL-17A is induced and is critical for the development of allergic lung inflammation, arthritis, bacterial sepsis, experimental allergic encephalomyelitis and myocarditis, as well as other inflammatory con- tions including organ transplantation. The role of IL-17F and IL-22 is still poorly defined and is only slowly emerging.

Zielgruppe

Research

Autoren/Hrsg.

Quesniaux, Valérie

Ryffel, Bernhard

Padova, Franco

Di Padova, Franco

Inhaltsverzeichnis

Discovery and IL-17 family.- IL-22 and IL-17: Common and different properties.- Other sources of IL-17: Invariant natural killer T cells.- Contributions of IL-22 to Th17 responses: Repairing and protecting peripheral tissues.- Retinoic acid in mucosal immune-regulation.- IL-25, another promoter of allergy.- Experimental models of disease.- Critical role of IL-17 in experimental arthritis.- Dual role of IL-17 in allergic asthma.- Contribution of IL-17 to the pulmonary inflammatory response.- The role of IL-17 in experimental autoimmune myocarditis.- Th17 cells in organ transplantation.- Role of IL-23/IL-17 in infection and tumor control.- Is IL-17 required to control tuberculosis?.- IL-17 and mucosal host defense.- IL-23 orchestrates the switch from tumor immune surveillance to tumor-promoting inflammation.- IL-17 in clinical autoimmune disease.- IL-17 and Th17 cells in rheumatoid arthritis.- Targeting Th17 cells in CNS immune pathology.- IL-17 cytokines in asthma.- IL-17/23, potential targets for Crohn’s disease.- Novel tools and therapeutic avenues.- IL-17A and Th17 cells as therapeutic targets for autoimmune diseases.