Poste / Nicolson Dynamic Aspects of Cell Surface Organization

Cell Surface Reviews
1. Auflage 2013
ISBN: 978-1-4831-6401-4
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 772 Seiten, Web PDF

Cell Surface Reviews, Volume 3: Dynamic Aspects of Cell Surface Organization reviews the progress in the study of the dynamic nature of membrane organization. The book is comprised of 14 chapters that discuss the various areas of concerns relating to membrane dynamics. The coverage of the text includes techniques and methods employed in the analysis and manipulation of the various aspects of cell membranes, such as freeze-fracture techniques; manipulation of the lipid composition of cultured animal cells; and somatic genetic analysis. The book also talks about some of the traits and behaviors of membrane dynamics including shedding of tumor cell surface antigens; dynamics of antibody binding and complement interactions at the cell surface; and structure and function of surface immunoglobulin of lymphocytes. The text will be of great use to microbiologists, biochemists, and other researchers whose work requires a good understanding of the various aspects of cells.

Autoren/Hrsg.

Poste, George

Nicolson, Garth L.

Inhaltsverzeichnis

1;Front Cover;1
2;Dynamic Aspects of Cell Surface Organization;4
3;Copyright Page;5
4;Table of Contents;18
5;General preface;6
6;Contents of previous and forthcoming volumes;8
7;Preface;12
8;List of contributors;16
9;Chapter 1. The dynamics of cell membrane organization;28
9.1;1. Introduction;28
9.2;2. Dynamics of cell membrane components;41
9.3;3. Mechanisms of receptor control;61
9.4;4. Trans-membrane architecture;75
9.5;Acknowledgments;78
9.6;References;79
10;Chapter 2. Freeze-fracture techniques and applications to the structural analysis of the mammalian plasma membrane;102
10.1;1. Introduction;102
10.2;2. Freeze-fracture technique;103
10.3;3. Interpretation of freeze-fracture images;107
10.4;4. Freeze-fracture images of plasma membranes;111
10.5;5. Intercellular junctions;127
10.6;6. Conclusions;144
10.7;Acknowledgement;145
10.8;References;145
11;Chapter 3. Exchange of phospholipids between membranes;154
11.1;1. Introduction;154
11.2;2. The origin of the hypothesis for exchange of phospholipids within the cell;156
11.3;3. Exchange of phospholipids between membranes;159
11.4;4. Phospholipid exchange involving lipoproteins;167
11.5;5. Involvement of proteins in the exchange of phospholipids between membranes;171
11.6;6. Phospholipid exchange in artificial (model) membranes;176
11.7;7. Purification and properties of phospholipid exchange proteins;181
11.8;8. Do phospholipid exchange proteins act as phospholipid carriers?;190
11.9;9. Nature of the interactions between phospholipid exchange proteins and bound phospholipids;195
11.10;10. Control of phospholipid exchange by membrane surface charge and the mode of action of phospholipid exchange proteins;202
11.11;11. Membrane asymmetry: implications for phospholipid exchange;209
11.12;12. The physiological significance of phospholipid exchange;214
11.13;13. Unanswered questions;218
11.14;Acknowledgments;218
11.15;References;219
12;Chapter 4. The influence of membrane fluidity on the activity of membrane-bound enzymes;232
12.1;1. Introduction;232
12.2;2. Lipid fluidity in model and biological membranes;236
12.3;3. Lipid fluidity and membrane enzymes;255
12.4;4. A regulatory role for membrane fluidity?;296
12.5;5. Concluding remarks;305
12.6;Acknowledgements;306
12.7;References;306
13;Chapter 5. Manipulation of the lipid composition of cultured animal cells;322
13.1;1. Introduction;322
13.2;2. Lipid metabolism;322
13.3;3. Lipid alterations;323
13.4;4. Some observations and generalizations;326
13.5;5. Conclusion;329
13.6;Acknowledgements;329
13.7;References;329
14;Chapter 6. Glycolipids as membrane receptors important in growth regulation and cell-cell interactions;334
14.1;1. Introduction;334
14.2;2. Glycolipid structure, biosynthesis, and nomenclature;335
14.3;3. Glycolipids in normal and transformed cells;335
14.4;4. Variations in glycolipid pattern in normal cells;349
14.5;5. Exposure of glycolipids at the cell surface;357
14.6;6. Correlation between altered glycolipid pattern and malignancy;362
14.7;7. Glycolipids as cell surface receptors;365
14.8;References;382
15;Chapter 7. Cell surface proteins : changes during cell growth and malignant transformation;398
15.1;1. Introduction;398
15.2;2. The human erythrocyte membrane as a model for the structure of mammalian cell surface membranes;399
15.3;3. Methods for studying cell surface proteins;405
15.4;4. Studies of surface glycoproteins of normal and transformed cells;418
15.5;Acknowledgements;437
15.6;References;437
16;Chapter 8. Shedding of tumor cell surface antigens;450
16.1;1. Introduction;450
16.2;2. Nature of tumor antigens and molecular expression at the cell surface;451
16.3;3. Tumor antigen shedding in vitro;459
16.4;4. Detection of antigens shed in vivo;469
16.5;5. Immunobiological effects of circulating antigens;481
16.6;6. Conclusion;487
16.7;Acknowledgements;487
16.8;References;487
17;Chapter 9. Expression of cell surface antigens on cultured tumor cells;500
17.1;1. Introduction;500
17.2;2. Cell surface antigens in non-synchronized cultures;500
17.3;3. Cell surface antigens in synchronized cultures;507
17.4;4. Macromolecular synthesis and the expression of cell surface antigens;520
17.5;5. Culture- and transformation-induced alterations of cell surface antigen expression;523
17.6;6. Conclusions;527
17.7;References;528
18;Chapter 10. Somatic genetic analysis of the surface antigens of murine lymphoid tumors;540
18.1;1. Rationale for the somatic analysis of surface antigens;540
18.2;2. Characteristics of murine lymphoid cell surface antigens which have been used in somatic genetic studies;544
18.3;3. Surface antigen variation in tumor cell populations;551
18.4;4. Genetic behavior of antigen loss variants;557
18.5;5. Future prospects;565
18.6;Acknowledgments;568
18.7;References;568
19;Chapter 11. Dynamics of antibody binding and complement interactions at the cell surface;578
19.1;1. Introduction;578
19.2;2. Cell surface molecules as antibody-binding structures;579
19.3;3. The precipitin reaction at the cell surface;583
19.4;4. Prozone ejects;592
19.5;5. Behaviour and fate of antibody following binding to the cell surface;598
19.6;6. The interaction of complement with antibodies at the cell surface;609
19.7;Acknowledgements;617
19.8;References;617
20;Chapter 12. Mitogen stimulation of B lymphocytes. A mitogen receptor complex which influences reactions leading to proliferation and differentiation;628
20.1;1. Introduction;628
20.2;2. Lymphocyte heterogeneity;630
20.3;3. The small B lymphocyte;630
20.4;4. The mitogens;631
20.5;5. The induction of B lymphocytes by mitogens;633
20.6;6. Proliferation and maturation of B lymphocytes;635
20.7;7. The role of surface membrane-bound Ig in the induction of B cells to growth and differentiation;636
20.8;8. Mitogen-receptors on B cells;639
20.9;References;641
21;Chapter 13. Structure and function of surface immunoglobulin of lymphocytes;646
21.1;1. Introduction;646
21.2;2. Detection of surface Ig;647
21.3;3. Class and antigen specificity of Ig;649
21.4;4. Topography and redistribution;653
21.5;5. Synthesis and dynamics of surface Ig;659
21.6;6. Summary;662
21.7;References;663
22;Chapter 14. Distribution and mobility of plasma membrane components on lymphocytes;670
22.1;1. Introduction;670
22.2;2. General characteristics of redistribution of lymphocyte surface components;671
22.3;3. Normal distribution of membrane components;676
22.4;4. Metabolically independent redistribution: patching;680
22.5;5. Metabolically dependent redistribution: capping;686
22.6;6. Fate of labelled material;731
22.7;7. Concluding remarks;740
22.8;Acknowledgments;740
22.9;References;740
23;Subject Index;756