Carbohydrate Chemistry

Chemical and Biological Approaches Volume 47
1. Auflage 2025
ISBN: 978-1-83767-549-4
Verlag: RSC Publishing

Buch, Englisch, 320 Seiten, Format (B × H): 156 mm x 234 mm

The understanding of the structure, recognition, and function of carbohydrates and glycoconjugates remains crucial in diverse areas at the interface of biology, chemistry and biotechnology and is driving innovation in biomedical and material sciences. This new volume contains critical reviews covering the current state-of-the-art and scientific advances in carbohydrate research and demonstrates cross-disciplinary areas within the field of glycosciences. Amongst the topics covered in Volume 47 are reviews focusing on the role of glycans in mechanisms of disease, highlighting the perspectives and challenges in diagnosis and their therapeutic potential as immune-checkpoints in cancer, inflammation and autoimmunity, and also evidencing a role in the pathogenesis of neurodegenerative diseases, such as Parkinson’s disease. This volume also covers current knowledge on glycan biosynthesis at the molecular level to understand and exploit structural features in different biological settings: tumour-associated O-glycans in cancer, mycobacterial polysaccharides in infection and peptidoglycan in biofilm formation. Sustainable synthesis from biomass-derived carbohydrates is also reviewed in Volume 47, from a perspective of renewable resources, highlighting selected examples of the most relevant value-added compounds. Finally, the volume also gathers reviews on technology-driven research highlighting emergent chemical and glycoengineering approaches for accessing the cancer glycoproteome and lectin-based tools for targeting disease biomarkers.

Autoren/Hrsg.

Pilar Rauter, Amélia

Queneau, Yves

Palma, Angelina Sá

Fachgebiete

• Naturwissenschaften Chemie Organische Chemie
• Naturwissenschaften Biowissenschaften Kohlenhydrate

Inhaltsverzeichnis

- N-Glycans as fundamental immune-checkpoints at the frontiers of inflammation, autoimmunity and cancer

- Keeping an eye on the sialyl-Tn target

- Exploring the complex role of protein glycosylation in the pathogenesis of Parkinson’s disease

- Glycosyltransferases in tumour-associated O-glycan biosynthesis: structural features and molecular recognition

- Mycobacterial pathways from simple glycosides to fatty acid-sheltering polymethylated polysaccharides

- Exploring the three-dimensional structures of LytR-CpsA-Psr proteins: implications for the maturation of the peptidoglycan

- Sustainable synthesis of value-added compounds from carbohydrates and carbohydrate-based platform molecules

- Emergent chemical and glycoengineering approaches for accessing the cancer glycoproteome

- Overview of glycans in disease: plant lectins as sensitive tools to decode glycosylation changes

Über Autor(innen)

Queneau, Yves
Dr Yves Queneau, Research Director at CNRS, is Head of the Organic and Bioorganic Chemistry Laboratory at INSA Lyon, Deputy-Director of the “Institut de Chimie et Biochimie Moléculaires et Supramoléculaires” (ICBMS), University of Lyon, France and Honorary Professor at the University of Hull, UK. After his doctorate on aqueous Diels-Alder reactions involving glycodienes under the supervision of Professor André Lubineau (Orsay, 1988) he was appointed as CNRS fellow and worked on cycloaddition reactions towards complex sugars. He then spent one year in 1992 in Professor Samuel J. Danishefsky’s group in Memorial Sloan Kettering Cancer Center in New York, USA. He later moved to Lyon in a mixed CNRS-industrial research facility dedicated to sucrose chemistry (1995-2003) before joining its present position where he develops his research in organic and biological chemistry with a particular interest for the use of carbohydrates as renewable raw materials.