Estimating Functional Connectivity and Topology in Large-Scale Neuronal Assemblies

Statistical and Computational Methods
1. Auflage 2021
ISBN: 978-3-030-59044-4
Verlag: Springer International Publishing

Buch, Englisch, 87 Seiten, Format (B × H): 155 mm x 235 mm, Gewicht: 172 g

Reihe: Springer Theses

This book describes a set of novel statistical algorithms designed to infer functional connectivity of large-scale neural assemblies. The algorithms are developed with the aim of maximizing computational accuracy and efficiency, while faithfully reconstructing both the inhibitory and excitatory functional links. The book reports on statistical methods to compute the most significant functional connectivity graph, and shows how to use graph theory to extract the topological features of the computed network. A particular feature is that the methods used and extended at the purpose of this work are reported in a fairly completed, yet concise manner, together with the necessary mathematical fundamentals and explanations to understand their application. Furthermore, all these methods have been embedded in the user-friendly open source software named SpiCoDyn, which is also introduced here. All in all, this book provides researchers and graduate students in bioengineering, neurophysiology and computer science, with a set of simplified and reduced models for studying functional connectivity in in silico biological neuronal networks, thus overcoming the complexity of brain circuits.

Zielgruppe

Research

Autoren/Hrsg.

Pastore, Vito Paolo

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Medizintechnik, Biomedizintechnik, Medizinische Werkstoffe
• Mathematik | Informatik EDV | Informatik Daten / Datenbanken Informationstheorie, Kodierungstheorie
• Mathematik | Informatik EDV | Informatik Informatik Berechenbarkeitstheorie, Komplexitätstheorie
• Mathematik | Informatik Mathematik Operations Research Graphentheorie
• Technische Wissenschaften Sonstige Technologien | Angewandte Technik Medizintechnik, Biomedizintechnik
• Interdisziplinäres Wissenschaften Wissenschaften: Forschung und Information Informationstheorie, Kodierungstheorie

Inhaltsverzeichnis

Introduction.- Materials and Methods.- Results.- Conclusion.