Neurogenetic Therapies

Advancements in Treating Nervous System Disorders
Erscheinungsjahr 2026
ISBN: 978-0-443-40574-7
Verlag: Elsevier Science

Buch, Englisch, 375 Seiten, Format (B × H): 191 mm x 235 mm, Gewicht: 449 g

Neurogenetic Therapies: Advancements in Treating Nervous System Disorders offers a comprehensive resource on the latest gene therapy techniques and their applications in treating neurological disorders. The book delves into various gene therapy methods, including genomic DNA-based therapies, vector-mediated delivery, and RNA interference-based gene silencing. It explores the use of these techniques in treating conditions such as Alzheimer's disease, Parkinson's disease, spinal muscular atrophy, and Duchenne muscular dystrophy. Key topics include the molecular and genetic basis of nervous system disorders, the role of epigenetics, and the development of stem cell and genome editing therapies.

With contributions from leading experts, the book also addresses regulatory and ethical considerations in gene therapy, providing a balanced perspective on the challenges and opportunities in this rapidly evolving field. Case studies and practical examples illustrate successful gene therapy treatments, offering valuable insights into translating research into clinical practice. This book is an essential resource for students, researchers, and scientists in neurogenetics, neurology, and molecular biology, as well as clinicians interested in the mechanisms and treatment of neurodegenerative diseases.

Autoren/Hrsg.

Pareek, Ashutosh

Singh, Arun Kumar

Chuturgoon, Anil

Pareek, Aaushi

Chiliza, Bonga

Fachgebiete

• Naturwissenschaften Biowissenschaften Biowissenschaften Genetik und Genomik (nichtmedizinisch)

Inhaltsverzeichnis

1. Molecular and Genetic Basis of Nervous System Disorders
2. Systems Biology Approaches in the Diagnosis of Neurological Disorders
3. Approaches for Gene Therapy and Its Possible Uses in Neurological Disorders
4. Genomic DNA-Based Gene Therapy: Recent Developments and Future Directions
5. Vector-Mediated Delivery of Transgenes and RNA Interference-Based Gene Silencing Sequences to Oligodendrocytes
6. Gene Transfer to Spinal Cord Neurons and Glial Cells through Adeno-Associated Virus Vector
7. Gene Therapy Models
8. Case Studies Based on Gene Therapies in Treating Neurological Disorders
9. Viral Gene Therapy Targets Astrocytes for Alzheimer's Disease
10. Lentiviral Gene Delivery of Orexin to Study Its Role in Alzheimer's Disease
11. Neurotrophin Gene Therapy for Parkinson's Disease Under Pharmacological Regulation
12. An Emerging Target for Parkinson's Disease Symptom and Medication Management: p11 Gene Therapy
13. Application of Gene Therapy Employing Stem Cells to Treat Neurological Disorders
14. Developing Human-Induced Pluripotent Stem Cells into Purkinje Neurons
15. Utilizing Herpes Simplex Virus Mutants as a Therapeutic Intervention for Neurogenic Pain
16. A Synopsis of Preclinical and Clinical Trials Concerning Immunotherapy Virotherapy for Astrocytoma
17. Nanoparticles in the Treatment of Neurological Disorders
18. Success Rates / Failures of Gene Therapy Techniques

Über Autor(innen)

Chiliza, Bonga
Dr. Bonga Chiliza is an Associate Professor and Head of the Department of Psychiatry at the University of KwaZulu-Natal in Durban, South Africa. He is the Deputy Editor of the South African Journal of Psychiatry and one of the Founding Directors of the Africa Global Mental Health Institute. He completed his medical degree and psychiatry specialization at the University of KwaZulu-Natal and his PhD at Stellenbosch University. His research interests include first-episode psychosis, schizophrenia, psych epidemiology and health services research and medical education. Prof Chiliza has received several awards from South African institutions and research grants from international funding agencies. He has published more than 120 peer-reviewed articles and book chapters. He has also led a number of not-for-profit boards, including the South African YMCA, the South African Society of Psychiatrists, and Harambee Medical Consulting.

Pareek, Ashutosh
Dr. Ashutosh Pareek, Associate Professor at Banasthali Vidyapith with over 15 years of experience in pharmaceutical sciences, holds gold medals for his Master's and Bachelor's degrees in Pharmacy. Dr. Pareek specializes in neuropharmacology and innovative drug delivery systems, focusing on neurodegenerative disorders, cancer, and autoimmune diseases. His research includes developing advanced drug delivery systems for immunomodulators like naringenin. Dr. Pareek leads a research team working on these critical health issues and has published over 45 research papers and authored five technical books. He holds an international formulation patent and has received numerous awards, including the Zee National Achievers Award 2023. His work is funded by national and international agencies such as ICMR, DST-SERB, DBT, the American Association of Pharmaceutical Scientists, and the International Brain Research Organization. He serves as a Review Editor for Frontiers in Pharmacology and Frontiers in Oncology and reviews for leading journals by Elsevier, Springer, and Bentham.

Chuturgoon, Anil
Prof. Anil Chuturgoon is a medical biochemist with a PhD in toxicology and epigenetics. He is a professor and head of medical biochemistry and is currently the dean of research at the College of Health Sciences. He is a B-rated medical scientist by the National Research Foundation of South Africa; he has published over 200 research papers and 12 chapters in books, and he has edited two books and many conference proceedings.
He actively researches epigenetic phenomena in toxicology and its implications in human diseases. He is a world expert on mycotoxins and their biological toxicity in humans. He pioneered research on fusariotoxins and epigenetics and their implication in disease. His contribution to Toxicology has been recognised by the CTD curator (NIEHS, USA), where 8 of his manuscripts are included in this database; the database provides manually curated information about chemical-gene/protein interactions, chemical-disease and gene-disease relationships. He has successfully supervised and graduated over 150 Masters and 50 PhD students. He serves as editor of several journals, including Nature: Scientific Reports and Frontiers in Reproductive Health.

Pareek, Aaushi
Dr Aaushi Pareek works as an Assistant Professor at Banasthali Vidyapith, India. Her research focuses on neuropharmacology and developing targeted drug-delivery systems for neurological and inflammatory diseases. As an independent principal investigator, she is deeply committed to advancing the understanding of neurodegenerative diseases through innovative therapeutic approaches. She holds an international formulation patent for developing polyphenol-loaded phytosomes for cancer treatment. She is also a distinguished recipient of international travel grants from the International Society for Neurochemistry (ISN) and the International Brain Research Organization (IBRO).

Singh, Arun Kumar
Arun Kumar Singh has completed M. Pharm (Pharmaceutics) from Galgotias University, Greater Noida, India. Mr. Singh joined as an assistant professor in the Department of Pharmacy, Vivekanand Global University Jaipur Rajasthan 303012. His area of interest is in the area of Nano-formulation, Blockchain, IoT, Machine learning, Cancer, Artificial intelligence, Big data, and Neuroscience. He has authored one book with IOP publishing. He has published 5 chapters in big data with the prestigious River Publisher, in Denmark. He has also published 20 review papers among which two are in Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. He has published 26 books with different publishers like IOP, Elsevier, CRC PRESS, and Wiley. His strengths are research skills, innovation, leadership, decision-making, and positive thinking. His hard-working nature and devotion to their work make him distinguishable and extraordinary.