Paoletti / Kritchevsky Advances in Lipid Research

1. Auflage 2014
ISBN: 978-1-4832-2442-8
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band Volume 3, 278 Seiten, Web PDF

Reihe: Advances in Lipid Research

Advances in Lipid Research, Volume 3 presents the analysis of human serum lipoproteins and emphasizes the possibilities inherent in the application of computer methods to such analyses. This book discusses the effects of various drugs on the other important component of the serum lipids, the phospholipids. Organized into six chapters, this volume begins with an overview of the possibility of a dehydrogenation toward the methyl group. This text then presents a detailed discussion of lipoprotein structure, metabolism, and catabolism. Other chapters consider some potentially significant revisions in lipoprotein procedure, including additions to the technology of lipoprotein analysis. This book discusses as well the chemistry and metabolism of plasma lipoprotein as related to physiological and disease states. The final chapter deals with the advances in methods of purification and studies of the properties and mode of action of lipases. This book is a valuable resource for organic chemists, neurochemists, and biochemists.

Autoren/Hrsg.

Paoletti, Rodolfo

Kritchevsky, David

Inhaltsverzeichnis

1;Front Cover;1
2;Advances in Lipid Research;4
3;Copyright Page;5
4;Table of Contents;10
5;CONTRIBUTORS TO THIS VOLUME;6
6;PREFACE;8
7;Chapter 1. The Metabolism of Polyenoic Fatty Acids;16
7.1;I. The Transformation of Oleic Acid into .5,8,11-C20-Trienoic
Acid;17
7.2;II. The Inconvertibility of One Type of Polyenoic Acid into
Another;18
7.3;III. The Behavior of the Isomers of Linoleic
and Linolenic Acids;22
7.4;IV. The Combustibility of the Polyenoic Acids;28
7.5;Addendum: Preparation by Total Synthesis of Unsaturated,
Especially Polyenoic, Fatty Acids;29
7.6;References;37
8;Chapter 2.
The Analysis of Human Serum Lipoprotein Distributions;40
8.1;I. Introduction and General Considerations of Human Serum
Lipoprotein Analysis;40
8.2;II. Some Unique Problems of Ultracentrifugal Lipoprotein Isolation and Flotation
Analysis;42
8.3;III. A Generalized Method for the Computer Analysis of Lipoprotein Distributions;47
8.4;IV. Application of Computer Analysis to a Series of Adult Normal Males and Females;60
8.5;V. Potential Improvements in the Computer Methodology for Lipoprotein
Analysis;73
8.6;References;75
9;Chapter 3. Factors Affecting Lipoprotein Metabolism;78
9.1;I. Introduction;79
9.2;II. Physical and Chemical Properties of
Plasma Lipoproteins;81
9.3;III. Experimental Approach to Lipoprotein Structure;89
9.4;IV. Biosynthesis of Plasma Lipoproteins;98
9.5;V. Catabolism of Plasma Lipoproteins;101
9.6;VI. Significance of Lipoproteins in Fat Transport;101
9.7;VII. Concluding Remarks;140
9.8;ACKNOWLEDGMENT;140
9.9;References;140
10;Chapter 4. The Action of Drugs on Phospholipid Metabolism;154
10.1;I. Introduction;154
10.2;II. Excitants and Antidepressants;156
10.3;III. Depressants;169
10.4;IV. Glycosides;177
10.5;V. Pharmacologically Active Phospholipids;178
10.6;References;182
11;Chapter 5. Brain Sterol Metabolism;186
11.1;I. Introduction;186
11.2;II. Distribution of Sterols in the Developing Brain;187
11.3;III. Distribution of Cholesterol in the Adult Mammalian Brain;192
11.4;IV. Brain Cholesterol Metabolism;195
11.5;V. Brain Sterols: the Effects of Drugs;204
11.6;VI. Brain Cholesterol: the Effects of Malnutrition;205
11.7;VII. Brain Sterols: the Effects of Disea;206
11.8;VIII. Conclusion;208
11.9;References;208
12;Chapter 6. Lipases;212
12.1;I. Introduction;212
12.2;II. Distribution of Lipases;214
12.3;III. Methods of Determining Lipase Activity;217
12.4;IV. Purification;219
12.5;V. Substrate Specificity and Mode of Action;222
12.6;VI. Factors Affecting the Velocity of Hydrolysis;229
12.7;VII. Lipoprotein Lipase;243
12.8;VIII. Summary;246
12.9;References;246
13;AUTHOR INDEX;256
14;SUBJECT INDEX;274