The UNC-53-mediated Interactome

Analysis of its Role in the Generation of the C. elegans Connectome
2014
ISBN: 978-3-319-07826-7
Verlag: Springer International Publishing

Buch, Englisch, 87 Seiten, Paperback, Format (B × H): 155 mm x 235 mm, Gewicht: 1591 g

Reihe: SpringerBriefs in Neuroscience

This book gives an overview of various interactomes involved in dorsal ventral (DV) and anterior posterior (AP) guidance, their mechanisms of action, subcellular localizations, and functional roles. It will provide readers a better understanding of the development of the nervous system, which in turn will help to find cures to various neural and other disorders.

In nematodes there are two types of guidance systems, including DV and AP guidance. The signaling process that guides the growth cones along the DV axis has remained intact in both vertebrates and invertebrates. The adaptor protein UNC-53 appears to play a part in migration along the AP axis in both worms and their human homologs. “Neuron Navigators” (NAV) are also involved in nervous system development 

Zielgruppe

Research

Autoren/Hrsg.

Pandey, Girdhar K.

Pandey, Amita

Fachgebiete

• Interdisziplinäres Wissenschaften Wissenschaften Interdisziplinär Neurowissenschaften, Kognitionswissenschaft
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Neurologie, Klinische Neurowissenschaft

Inhaltsverzeichnis

Introduction.- Guidance molecules required for growth cone migrations of cells and axons.- Mechanism for asymmetric localization of guidance receptors during growth cone migration and outgrowth.- Signaling pathways downstream of the guidance cues and receptors.- Functional characterization of adaptor protein UNC-53 during axon outgrowth and cell migration.