Modelling Degradation of Bioresorbable Polymeric Medical Devices

Erscheinungsjahr 2014
ISBN: 978-1-78242-016-3
Verlag: Elsevier Science

Buch, Englisch, 260 Seiten, Format (B × H): 156 mm x 234 mm, Gewicht: 530 g

The use of bioresorbable polymers in stents, fixation devices and tissue engineering is revolutionising medicine. Both industry and academic researchers are interested in using computer modelling to replace some experiments which are costly and time consuming. This book provides readers with a comprehensive review of modelling polymers and polymeric medical devices as an alternative to practical experiments. Chapters in part one provide readers with an overview of the fundamentals of biodegradation. Part two looks at a wide range of degradation theories for bioresorbable polymers and devices. The final set of chapters look at advances in modelling biodegradation of bioresorbable polymers. This book is an essential guide to those concerned with replacing tests and experiments with modelling.

Zielgruppe

R&D managers in the biomaterials and polymer chemical industry concerned with modelling and in vitro testing.  In particular those concerned with the regulatory procedures and testing of polymer medical devices.

Autoren/Hrsg.

Pan, J.

Fachgebiete

• Technische Wissenschaften Maschinenbau | Werkstoffkunde Technische Mechanik | Werkstoffkunde Materialwissenschaft: Polymerwerkstoffe
• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Technologie der Kunststoffe und Polymere
• Technische Wissenschaften Maschinenbau | Werkstoffkunde Technische Mechanik | Werkstoffkunde Materialwissenschaft: Biomaterialien, Nanomaterialien, Kohlenstoff

Inhaltsverzeichnis

Part One: Fundamental methods of modelling degradation of bioresorbable polymeric medical devices 1. Introduction to computer modelling for the design of biodegradable medical devices 2. Modelling degradation of amorphous biodegradable polyesters: basic model 3. Modelling degradation of amorphous biodegradable polyesters: advanced model 4. Modelling degradation of semi-crystalline biodegradable polyesters 5. Modelling biodegradation of composite materials made of biodegradable polyesters and tricalcium phosphates (TCPs) 6. Modelling heterogeneous degradation of polymeric devices due to short chain diffusion

Part Two: Advanced methods of modelling degradation of bioresorbable polymeric medical devices 7. Finite element analysis (FEA) of biodegradation of polymeric medical devices 8. The effective diffusion coefficient of degrading polymers 9. Mechanical properties of biodegradable polymers for medical applications 10. Molecular and multi-scale modelling methods of polymer device degradation

Über Autor(innen)

Pan, J.
Jingzhe Pan, University of Leicester, UK