Pairet / Ryn COX-2 Inhibitors

Erscheinungsjahr 2012
ISBN: 978-3-0348-7879-1
Verlag: Springer
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 250 Seiten, eBook

Reihe: Milestones in Drug Therapy

COX-2 inhibitors are important drugs with analgesic and anti-inflammatory effects. The discovery of COX-2, the evolution of drug development in this field and the implications of these developments in patient therapy are topics of this volume. This book presents both pre-clinical and clinical information and is important for clinicians interested in the latest information about this class of drugs, for researchers and for students in the field.

Zielgruppe

Professional/practitioner

Autoren/Hrsg.

Pairet, Michel

Ryn, Joanne van

Inhaltsverzeichnis

The discovery of COX-2.- Structural diversity of selective COX-2 inhibitors.- The molecular and biological basis for COX-2 selectivity.- Pharmacology and toxicology of COX-2 inhibitors.- Efficacy and gastrointestinal safety of selective COX-2 inhibitors.- Role of COX-2 in ulcers and ulcer healing.- COX-2 and the cardiovascular system.- Effects on the kidney: role of COX-2 inhibitors.- Effects on the lungs: role of COX-2 inhibitors.- Reproduction: role of COX-2 and its inhibition.- COX-2 in cancer.