Chemical Biology Techniques and Applications
E-Book, Englisch, 312 Seiten, E-Book
ISBN: 978-0-470-49500-1
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)
Protein Targeting with Small Molecules: Chemical BiologyTechniques and Applications takes readers beyond the use ofchemical biology in basic research, providing a highly relevantlook at techniques that can address the challenges of biology anddrug design and development.
This indispensable bench companion features up-to-date coverageof advances in chemistry and assesses their impact on developingnew therapeutics, making it ideal for chemical biologists andmedicinal chemists who are developing small molecule drugs totarget proteins and treat diseases. In addition, the book examinesthe full range of complex biological systems and theirinterrelationship with chemistry, from the interaction ofbiological response modifiers with proteins to the chemical biologyof cell surface oligosaccharides.
Distinguished by an overview of chemical biology that isreinforced and clarified by detailed examples and descriptions oftechniques, Protein Targeting with Small Molecules: ChemicalBiology Techniques and Applications:
* Introduces key technologies and methods of chemical biologydesigned to detect the interactions of small molecules andproteins
* Facilitates the discovery of small molecules that bind toproteins and describes the molecules' application in theinvestigation of biological processes
* Presents timely coverage of the development of fluorescentprobes for small molecules, as well as the generation of smallmolecule ligands and inhibitors
* Reviews important techniques such as chemical genomics, targetprofiling, immobilization technology, detection methods, chemicalinhibition, and structure-based targeting
* Offers a compelling synopsis of data that underscores therecent progress made in the area of targeting proteins by smallmolecules
Autoren/Hrsg.
Weitere Infos & Material
Contributors.
Preface.
Chapter 1: Chemical biology based on the small molecule-proteininteraction (Hiroyuki Osada).
Chapter 2: Target Profiling of Small Molecules (Leonid L.Chepelev, and Michel Dumontier).
Chapter 3: Novel application of affinity beads (Yasuaki Kabe,Mamoru Hatakeyama, Satoshi Sakamoto, Kousuke Nishio, and HiroshiHanda).
Chapter 4: Immolization of small molecules on solid phase(Naoki Kanoh, and Hiroyuki Osada).
Chapter 5: Application of phage display technique to identifythe target protein (Yoon Sun Cho and Ho Jeong Kwon).
Chapter 6: Development of fluorescent probes for small molecules(Adrian P. Neal, and Carsten Schultz).
Chapter 7: Development of small molecule ligands and inhibitors(Leonid L. Chepelev, Nikolai L. Chepelev, Hooman Shadnia,William G. Willmore, James S. Wright, and MichelDumontier).
Chapter 8: Interaction of biological response modifier withproteins (Yuichi Hashimoto).
Chapter 9: Chemical biology of cell motility inhibitors(Tatsuro Kawamura, Mitsuhiro Kitagawa, and MasayaImoto).
Chapter 10: Chemical biology of cell surface oligosaccarides(Prabhani U. Atukorale, Sean S. Choi, Udayanath Aich,Christopher T. Campbell, M. Adam Meledeo, and Kevin J.Yarema).
Chapter 11: Chemical genomics based on yeast genetics(Shinichi Nishimura, and Yoko Yashiroda Minoru Yoshida).
Chapter 12: Data Fact of small molecules and their targetproteins (Takeo Usui, Akiko Saito, and Hiroyuki Osada).
Index.
