The Nucleolus

2011
ISBN: 978-1-4614-3012-4
Verlag: Springer US

Buch, Englisch, 414 Seiten, Previously published in hardcover, Format (B × H): 155 mm x 235 mm, Gewicht: 663 g

Reihe: Protein Reviews

Within the past two decades, extraordinary new functions for the nucleolus have begun to appear, giving the field a new vitality and generating renewed excitement and interest. These new discoveries include both newly-discovered functions and aspects of its conventional role.  The Nucleolus is divided into three parts: nucleolar structure and organization, the role of the nucleolus in ribosome biogenesis, and novel functions of the nucleolus.

Zielgruppe

Research

Autoren/Hrsg.

Olson, Mark O. J.

Fachgebiete

• Naturwissenschaften Biowissenschaften Proteinforschung
• Naturwissenschaften Biowissenschaften Zellbiologie

Inhaltsverzeichnis

Nucleolar Structure and Organization.Structural organization of the nucleolus as a consequence of the dynamics of ribosome biogenesis.The dynamic proteome of the nucleolus.The Structure of rDNA Chromatin.The epigenetics of the nucleolus: structure and function of active and silent ribosomal RNA genes.UBF, an Essential Player in Maintenance of Active NORs and nucleolar formation.- Role of the Nucleolus in Ribosome Biogenesis.The RNA Polymerase I Transcription Machinery.Small Ribonucleoproteins in Ribosome Biogenesis.Crosstalk between ribosome synthesis and cell cycle progression and its potential implications in human genetic disease.The multiple properties and functions of nucleolin.The multifunctional nucleolar protein nucleophosmin/NPM/B23 and the nucleoplasmin family of proteins.Structure and function of NOPP140 and treacle.- Novel Functions of the Nucleolus.The Role of the Nucleolus in the Stress Response.New Frontiers in Nucleolar Research - Nucleostemin and Related Proteins.Viruses and the Nucleolus.Assembly of Signal Recognition Particles in the Nucleolus.Relationship of the Cajal Body to the Nucleolus.Role of the Nucleolus in HIV Infection and Therapy.