Multiscale Cell-Biomaterials Interplay in Musculoskeletal Tissue Engineering and Regenerative Medicine

Erscheinungsjahr 2023
ISBN: 978-0-323-91821-3
Verlag: Elsevier Science

Buch, Englisch, 554 Seiten, Format (B × H): 191 mm x 235 mm, Gewicht: 450 g

Multiscale Cell-Biomaterials Interplay in Musculoskeletal Tissue Engineering and Regenerative Medicine addresses the key concepts involved in the interactions between cells and biomaterials in the musculoskeletal tissue engineering and regenerative medicine field. The updated developments and challenges of the mechanisms/mechanobiology and structure-function properties of those interactions, as well as emerging technologies underlying tissue-engineered scaffolding, are carefully discussed. Lastly, cell engineering and cell-based therapies, growth factors/drugs properties, vascularization, immunomodulation are also outlined.

Given the large number of musculoskeletal disorders and related injuries that can affect muscles, bones and joints and lead to severe complications of the neuromuscular system, it is imperative to develop new treatment strategies to delay or repair associated diseases and to promote optimal long-term health.

Autoren/Hrsg.

Oliveira, J Miguel

Reis, Rui L.

Pina, Sandra

Fachgebiete

• Naturwissenschaften Biowissenschaften Biowissenschaften

Inhaltsverzeichnis

Section 1: Fundamentals of cell-biomaterials interactions 1. Introduction 2. Fundamentals and mechanisms 3. Cellular signaling processes 4. Cell-protein interactions 5. The microenvironment: Recreate the ECM 6. Surface modifications - topography, porosity 7. Chemotaxis: Soluble morphogens and Growth factors 8. Cell-biomaterials: Vascularization 9. Cell-biomaterials in Immunomodulation 10. Mechanobiology regulation 11. Electrical/Magnetic stimulation

Section 2: Multiscale design, structure/function and processing technologies 12. Introduction 13. Design of polymeric biomaterials at multiscale 14. Design of Calcium phosphates cements: Structure/function 15. Biomimetic micro-/nano- scales design 16. Cells-biomaterials structure-function at different length scales 17. Computational modelling involved in multiscale design 18. Hydrogel systems design: Structure/function 19. Scaffolding design and structure/function: Electrospinning 20. Scaffolding design and structure/function: Advanced manufacturing 21. Scaffolding design and structure/function: Bioprinting 22. Dynamic models for investigating structure/function of biomaterials: Bioreactors 23. Dynamic models for investigating cell-biomaterials interactions: Microfluidics 24. Complex in vitro models for studying cell-biomaterials interactions 25. In vivo animal models 26. Regulatory and clinical translation

Über Autor(innen)

Pina, Sandra
Sandra Pina is Assistant Researcher at 3B's Research Group, Institute 3B's, University of Minho, Barco, Portugal.

Reis, Rui L.
Dr. Rui Reis is Vice-President for Research and Innovation of University of Minho, Portugal, Director of 3B's Research Group and Director of ICVS/3B´s Associate Laboratory, both of UMinho. He's the CEO of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, the Coordinator of the Discoveries Centre for Regenerative and Precision Medicine, the Global Past-President of the Tissue Engineering and Regenerative Medicine International Society and the Editor-in-chief of the Journal of Tissue Engineering and Regenerative Medicine. He's edited 18 books, 10 special issue journals, 280 book chapters and has more than 1225 published works listed on ISI Web of Knowledge, being an inventor of around 70 patents. He's been awarded many important international prizes, including the TERMIS-EU contributions to the literature Award and the TERMIS-EU Career Achievement Award, and recently the UNESCO- International Life Sciences Award and the IET A. F. Harvey Engineering Research Prize.