Neve The Dopamine Receptors

Erscheinungsjahr 2013
ISBN: 978-1-4757-2635-0
Verlag: Humana Press
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 553 Seiten, eBook

Reihe: The Receptors

Seven years after the cloning of the rat dopamine D receptor, and four 2 years after the cloning of the last mammalian dopamine receptor identified to date, this seems to be an excellent time to put together the present The Dopamine Receptors volume ofthis series, The Receptors. There has been time for considerable characterization of the novel receptor subtypes, and new, exciting lines of research from the molecular to the behavioral levels are taking shape. We asked the contributors to The Dopamine Receptors to follow the superb example set by the previous volumes in this series by writing compre hensive, historical reviews that will comprise an essential resource for nonspe cialists and newcomers to the dopamine receptor field, while at the same time providing up-to-date summaries of the most active areas of research. It is difficult these days to write about receptors without addressing the issue of receptor nomenclature. For dopamine receptors, valid arguments can be made for a system in which the subtypes are classified as belonging to the Dl or D2 classes, with letters assigned in the order of cloning (D A, D , D A, 1 18 2 D , Dc). We decided, however, that common usage counts for something, and 28 2 chose to use D , D , and D for the D2-like receptors because these names are 2 3 4 nearly unanimously used in the literature.

Zielgruppe

Research

Autoren/Hrsg.

Neve, Kim

Neve, Rachael L.

Inhaltsverzeichnis

I Characterization of Dopamine Receptors.- 1 • Biochemical Characterization of Dopamine Receptors.- 2 • Molecular Biology of Dopamine Receptors.- 3 • Distribution of Dopamine Receptors.- 4 • Molecular Drug Design and Dopamine Receptors.- II. Biochemical Mechanisms of Receptor Action.- 5 • Interactions of Dopamine Receptors with G Proteins.- 6 • Signaling Pathways Modulated by Dopamine Receptors.- 7 • D1/D2 Dopamine Receptor Interactions in Basal Ganglia Functions.- III. Dopamine Receptors and Function.- 8 • Dopamine Autoreceptor Pharmacology and Function: Recent Insights.- 9 • Electrophysiological Effects of Dopamine Receptor Stimulation.- 10 • Dopamine Receptor Modulation of Gene Expression in the Brain.- 11 • Dopamine Receptor-Mediated Gene Regulation in the Pituitary.- 12 • Mechanisms of Dopaminergic Regulation of Prolactin Secretion.- 13 • Regulation of Dopamine Receptor Function and Expression.- 14 • Regulation of Motor Behavior by Dopamine Receptor Subtypes: An Antisense Knockout Approach.- 15 • Dopamine Receptors and Clinical Medicine.- 16 • Dopamine Receptors and Cognitive Function in Nonhuman Primates.