Neidle, S: PRINCIPLES OF NUCLEIC ACID STR

Erscheinungsjahr 2007
ISBN: 978-0-12-369507-9
Verlag: William Andrew Publishing

Buch, Englisch, 302 Seiten, Format (B × H): 184 mm x 259 mm, Gewicht: 653 g

This unique and practical resource provides the most complete and concise summary of underlying principles and approaches to studying nucleic acid structure, including discussion of x-ray crystallography, NMR, molecular modelling, and databases. Its focus is on a survey of structures especially important for biomedical research and pharmacological applications. To aid novices, Principles of Nucleic Acid Structure includes an introduction to technical lingo used to describe nucleic acid structure and conformations (roll, slide, twist, buckle, etc.). This completely updated edition features expanded coverage of the latest advances relevant to recognition of DNA and RNA by small molecules and proteins. In particular, the reader will find extensive new discussions on: RNA folding, ribosome structure and antibiotic interactions, DNA quadruplexes, DNA and RNA protein complexes, and short interfering RNA (siRNA). This handy guide ends with a complete list of resources, including relevant online databases and software.

Zielgruppe

Researchers in biochemistry, as well as for advanced undergraduate and graduate students studying nucleic acid structure and function.

Autoren/Hrsg.

Neidle, Stephen

Fachgebiete

• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)
• Naturwissenschaften Physik Angewandte Physik Biophysik
• Naturwissenschaften Biowissenschaften Molekularbiologie
• Naturwissenschaften Biowissenschaften Angewandte Biologie Biophysik

Inhaltsverzeichnis

Methods for Studying Nucleic Acid Structure.
The building-blocks of DNA and RNA.
DNA Structure as Observed in Fibres and Crystals.
DNA-DNA recognition: non-standard and higher-order DNA structures.
Principles of small molecule-DNA Recognition.
The RNA structural world.
Principles of Protein-DNA Recognition.

Über Autor(innen)

Neidle, Stephen
Stephen Neidle is an Emeritus Professor of Chemical Biology at University College London, where he has also been the Director of Research in the School of Pharmacy. He has published over 500 primary papers and reviews and is a principal inventor on 14 patent filings. He has also written and edited several books on nucleic acids and anti-cancer drugs.