Narain Chemistry of Bioconjugates

Synthesis, Characterization, and Biomedical Applications
1. Auflage 2013
ISBN: 978-1-118-77640-7
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 496 Seiten, E-Book

Explores bioconjugate properties and applications ofpolymers, dendrimers, lipids, nanoparticles, and nanotubes
Bioconjugation has enabled breakthroughs across many areas ofindustry and biomedicine. With its emphasis on synthesis,properties and applications, this book enables readers tounderstand the connection between chemistry and the biologicalapplication of bioconjugated materials. Its detailed descriptionsof methods make it possible for researchers to fabricate and takefull advantage of bioconjugates for a broad range of applications.Moreover, the book sets the foundation for the development of newapplications, including assays, imaging, biosensors, drug delivery,and diagnostics.
Chemistry of Bioconjugates features contributions from aninternational team of leading experts and pioneers in the field.These contributions reflect the authors' firsthand laboratoryexperience as well as a thorough review of the current literature.The book's six sections examine:
* General methods of bioconjugation
* Polymer bioconjugates
* Organic nanoparticle-based bioconjugates
* Inorganic nanomaterial bioconjugates, including metals andmetal oxides
* Cell-based, hydrogel/microgel, and glyco-bioconjugates
* Characterization, physico-(bio)chemical properties, andapplications of bioconjugates
This comprehensive exploration of bioconjugates includesdiscussions of polymers, dendrimers, lipids, nanoparticles, andnanotubes. References at the end of each chapter serve as a gatewayto the most important original research findings and reviews in thefield.
By drawing together and analyzing all the latest chemicalmethods and research findings on the physico-chemical andbiochemical properties of bioconjugates, Chemistry ofBioconjugates sheds new light on the significance and potentialof bioconjugation. The book is recommended for organic and polymerchemists, biochemists, biomaterial scientists, carbohydratechemists, biophysicists, bioengineers, and drug and gene deliveryscientists.

Autoren/Hrsg.

Narain, Ravin

Inhaltsverzeichnis

PREFACE vii
CONTRIBUTORS ix
SECTION I GENERAL METHODS OF BIOCONJUGATION
1 Covalent and Noncovalent Bioconjugation Strategies 3
Rajesh Sunasee and Ravin Narain
SECTION II POLYMER BIOCONJUGATES
2 Bioconjugates Based on Poly(Ethylene Glycol)s andPolyglycerols 79
Rajesh A. Shenoi, Fang Gao, Muhammad Imran ul-Haq, andJayachandran N. Kizhakkedathu
3 Synthetic Polymer Bioconjugate Systems 104
Marya Ahmed and Ravin Narain
4 Natural Polymer Bioconjugate Systems 133
Lichao Liu, Xiuwei Pan, and Weian Zhang
5 Dendrimer Bioconjugates: Synthesis and Applications 146
Ali Nazemi and Elizabeth R. Gillies
SECTION III ORGANIC NANOPARTICLES BASED BIOCONJUGATES
6 Bioconjugation Strategies: Lipids, Liposomes, Polymersomes,and Microbubbles 187
Anirban Sen Gupta and Horst A. von Recum
7 Organic Nanoparticle Bioconjugate: Micelles, Cross-LinkedMicelles, and Nanogels 203
Maria Vamvakaki
8 Carbon Nanotubes and Fullerene C60 Bioconjugates 239
Keshwaree Babooram and Ravin Narain
SECTION IV INORGANIC NANOMATERIALS BIOCONJUGATES (METALS,METAL OXIDES--QUANTUM DOTS, IRON-OXIDE)
9 Gold Nanomaterials Bioconjugates 257
Qian Yang
10 Methods for Magnetic Nanoparticle Synthesis andFunctionalization 281
Mohammad H. El-Dakdouki, Kheireddine El-Boubbou, Jingguang Xia,Herbert Kavunja, and Xuefei Huang
11 Quantum Dots Bioconjugates 315
Xiaoze Jiang, Meifang Zhu, and Ravin Narain
12 Silica Nanoparticle Bioconjugates 327
Yohei Kotsuchibashi, Mitsuhiro Ebara, and Ravin Narain
13 Polyhedral Oligomeric Silsesquioxanes (POSS) Bioconjugates344
Weian Zhang, Zhenghe Zhang, and Lizhi Hong
SECTION V CELL-BASED, HYDROGELS/MICROGELS ANDGLYCO-BIOCONJUGATES
14 Cell-Based Bioconjugates 357
Mitsuhiro Ebara
15 Bioresponsive Hydrogels and Microgels 370
Xue Li and Michael J. Serpe
16 Conjugation Strategies Used for the Preparation ofCarbohydrate-Conjugate Vaccines 387
Rachel Hevey and Chang-Chun Ling
SECTION VI CHARACTERIZATION, PHYSICO-(BIO)CHEMICALPROPERTIES, AND APPLICATIONS OF BIOCONJUGATES
17 Properties and Characterization of Bioconjugates 417
Ali Faghihnejad, Jun Huang, and Hongbo Zeng
18 Physico-Chemical and Biochemical Properties of Bioconjugates431
Marya Ahmed and Ravin Narain
19 Applications of Bioconjugates 444
Marya Ahmed and Ravin Narain
INDEX 457

Über Autor(innen)

RAVIN NARAIN, PhD, is Associate Professor in theDepartment of Chemical and Materials Engineering at the Universityof Alberta. He has published more than 100 articles inpeer-reviewed journals and is the editor of EngineeredCarbohydrate-Based Materials for Biomedical Applications(Wiley). Dr. Narain's research examines nanomedicine andregenerative medicine, with an emphasis on developing newbiomaterials for gene delivery and tissue engineering.