Apoptosis

Erscheinungsjahr 2013
ISBN: 978-1-61504-538-9
Verlag: Biota Publishing

Buch, Englisch, 101 Seiten, Paperback, Format (B × H): 191 mm x 235 mm, Gewicht: 219 g

Reihe: Colloquium Series on Building Blocks of the Cell: Cell Structure and Function

Multi-cellular organisms eliminate individual cells through a self-destruct process known as apoptosis. Apoptosis is critical for proper development and maintenance of tissue homeostasis. The importance of this process is highlighted by the fact that too much or too little apoptosis is the underlying cause of pathologies such as cancer, autoimmune diseases (e.g., lupus, arthritis), and neurodegenerative disorders (e.g., Parkinson's, Alzheimer's). In the early days, apoptotic cells were identified strictly by cell morphology. Now we know that biochemical signatures define a number of death programs, of which apoptosis is the most widely understood. In this review, we discuss genetic insights gained from C. elegans, the importance of caspases, engulfment of apoptotic cells, apoptotic signals, the role of mitochondria, the Bcl-2 family, and the link between dysfunctional apoptosis and disease. Within each topic, we highlight landmark studies that contributed to our current understanding of apoptosis. All together, this research exemplifies tremendous scientific synergy between the disciplines of genetics, biochemistry, developmental cell biology, and structural biology. Continued exploration into mechanisms that regulate apoptosis will undoubtedly lead to insights into disease processes with potential therapeutic strategies.

Autoren/Hrsg.

Naik, Urja

Yang, Ning

Goping, Inge Swie

Inhaltsverzeichnis

- Historical Perspective of Apoptosis
- C. elegans and Discovery of the Caspases
- Engulfment of Apoptotic Cells: “Find Me” and “Eat Me” Signals
- Extrinsic and Intrinsic Apoptotic Signals
- The Bcl-2 Family
- Apoptosis and Cancer
- Summary
- References
- Author Biographies