Hepatic Fibrosis

Mechanisms and Targets
Erscheinungsjahr 2022
ISBN: 978-0-323-99764-5
Verlag: Elsevier Science & Technology

Buch, Englisch, 274 Seiten, Format (B × H): 232 mm x 190 mm, Gewicht: 564 g

Hepatic Fibrosis: Mechanisms and Targets is a complete volume of liver extracellular matrix biology, including molecular signaling pathways, cells and factors that modulate fibrogenesis and fibrosis. The book uses an integrated approach toward the molecular and cellular mechanisms involved in the synthesis and degradation of hepatic fibrotic tissue, emphasizing the possible molecular targets to fight fibrosis. This important reference describes, in detail and didactically, the cellular and molecular events that are conducive to fibrosis that leads to cirrhosis, hepatocellular carcinoma and death. The provided information allows readers to understand the molecular mechanisms of hepatic fibrogenesis to accelerate the development of new therapies.

Zielgruppe

<p>Basic and clinical scientists and clinicians working in the biological sciences, especially those dedicated to the study and treatment of liver diseases, fibrosis, and those interested in molecular biology and mechanisms of diseases. Gastroenterologists, hepatologists, and other physicians. First degree and postgraduate students of medicine and other students in the biological area, molecular biologists, etc. </p> <p>Pharmaceutical companies may find this book useful for the development of new drugs based on the molecular targets described in each chapter.</p>

Autoren/Hrsg.

Muriel, Pablo

Fachgebiete

• Naturwissenschaften Biowissenschaften Biowissenschaften

Inhaltsverzeichnis

1. Healthy and diseased extracellular matrix of the liver 2. From inflammation to fibrosis 3. Cells, cytokines, and factors involved in profibrogenic pathways 4. Role of free radicals in hepatic fibrogenesis 5. Role of gut dysbiosis in chronic liver disease leading to fibrosis 6. Alcohol-induced fibrosis 7. From fatty liver to nonalcoholic steatohepatitis with fibrosis 8. Viral hepatitis-induced liver fibrosis 9. Biliary fibrosis 10. Experimental models of hepatic fibrosis 11. Monitoring hepatic fibrosis

Über Autor(innen)

Muriel, Pablo
Dr. Muriel PhD has research experience in the pathophysiology and pharmacology of liver diseases including necrosis, fibrosis and cholestasis; the role of cytokines in liver diseases; and oxidative stress and its relation to liver disease. He has published over 100 articles (original and reviews) in addition to 7 book chapters in the area of the liver and has also directed the thesis on dozens of postgraduate students in the same area over the last 30 years. The majority of his work has been in the Medicine and Pharmacology areas. He shows strong and growing citation counts from 2010-2017.