Clinical Cancer Genomic Medicine

Erscheinungsjahr 2026
ISBN: 978-0-443-15321-1
Verlag: Elsevier Science

Buch, Englisch, 700 Seiten, Format (B × H): 191 mm x 235 mm

Clinical Cancer Genomic Medicine: Translational and Applied covers all major aspects of genetics and genomic of cancer development, diagnosis, and management and the use of them in the clinical setting. It aims to provide readers with not only the genetic basis of cancer, but the role genomics play in understanding the molecular basis of the disease along with aiding diagnosis and treatment.The content is split into three parts: the first, Fundamentals of Cancer Genetics and Genomics, discusses the basics of oncogenomic and emerging technologies; the second, Clinical Cancer Genetics and Genomics, brings information on specific cancer types, such as breast, gastrointestinal, ocular, skin and pediatric; and the third, Clinical Cancer Genomic Medicine, encompasses knowledge on diagnostic cancer genomic techniques, surgical approaches, and ethical, legal, and social implications of cancer genomic testing.It is a valuable resource for oncologists, clinicians, researchers, healthcare workers and members of biomedical field who needs to understand more about the benefits of genetics and genomics for cancer and their application in clinical setting.

Autoren/Hrsg.

Morgan, Claire

Davies, Mark

Kumar, Dhavendra

Weitere Mitwirkende

Maher, Eamonn

Fachgebiete

• Mathematik | Informatik EDV | Informatik Business Application Unternehmenssoftware
• Wirtschaftswissenschaften Betriebswirtschaft Unternehmensforschung

Inhaltsverzeichnis

Section I: Fundamentals of Cancer genetics and genomics
1. The human genome- organisation & function
2. Introduction to cancer genetics
3. Oncogenes and tumour suppressor genes
4. Cancer epigenomics
5. Cancer and the microbiome- the Oncobiome
6. Cancer immunogenomics
7. Cancer pharmacogenomics
8. Genomic Technologies for Tumour Profiling
9. New emerging technologies- The liquid biopsy
10. Gene and genome editing
11. Bioinformatics for Cancer Genome Analysis

Section II: Clinical cancer genetics and genomics
12. Classification and epidemiology of the genetic and inherited cancer - hereditary cancer family syndromes

13. Breast and ovarian cancer including endometrial cancer

14. Gastrointestinal malignancies - oesophagus, colo-rectal, hepato-biliary and pancreatic

15. Central nervous system tumours

16. Neoplasia of endocrine system (solitary and multiple)

17. Ocular tumours - retinoblastoma

18. Hematological cancer and lympho-reticular malignancy

19. Oro-pharyngeal and lung cancers

20. Malignant melanoma and related skin neoplasia

21. Childhood tumours and paediatric malignant neoplasia disorders

22. Malformation syndromes with neoplasia

Section III: Clinical cancer genomic medicine
23. Integration of cancer genomics in clinical medicine

24. Cancer genetic counselling

25. Diagnostic cancer genomic laboratory - organization & function / cancer database

26. Targeted therapy and screening in cancer genomic / precision medicine

27. Surgical approaches in clinical cancer genetics and genomics

28. Ethical, legal and social implications of cancer genomic testing

29. The future of cancer in the context of the genomics era

Über Autor(innen)

Kumar, Dhavendra
Professor Kumar has considerable previous experience in writing and editing books and journals related to genetics and genomics. His books include Genomics and Clinical Medicine and Genomics and Health in the Developing World. He founded and leads the new open access journal Applied and Translational Genomics, published by Elsevier. He has published 40 articles in the journals literature.
Professor Dhavendra Kumar is a Visiting Professor, Genomic Policy Unit, Faculty of Life Sciences and Education, The University of South Wales and Consultant in Clinical Genetics at the University Hospital of Wales, Institute of Medical Genetics, Cardiff University, Cardiff, United Kingdom. He is one of the Consultants for the All Wales Medical Genetics Service and the lead Clinician for Clinical Cardiovascular Genetics. After qualifying in Medicine from the King George's Medical College, University of Lucknow, India, he completed postgraduate training in Pediatrics with an MD. Since 1980 he has pursued a career in Medical Genetics in the UK. In 1990 he became a Diplomate of the American Board of Medical Genetics. He is a Fellow of the American College of Medical Genetics (FACMG) and as well as Royal Colleges of Physicians (FRCP-London and FRCP-Ireland) and Pediatrics and Child Health (FRCPCH-UK).

In 2015, he was conferred with the higher degree of DSc by his Alma Mater, King George's Medical University, Lucknow (UP, India) based on his life-time contributions and achievements to genetic and genomic applications in medicine and health.

Morgan, Claire
Dr. Claire Morgan is Associate Professor in cancer genetics and the Programme Director for the MSc Genomic Medicine course. As the Programme Director, established and leads the first fully NHS-supported Genomic Medicine course in Wales; serves as an invited member of Genomics Partnership Wales and Wales Gene Park Strategic Advisory group and the Genomic Medicine UK advisory Group.

In addition, Programme Director for the BSc Genetics and Medical Genetics degree schemes and teaches on all the UG degree schemes including the Genetics/ Medical Genetics/Applied Medical Sciences and Population Health and Medical Sciences BSc degree schemes in the School of Medicine.

Maher, Eamonn
Professor Maher is an international authority in clinical cancer genetics and genomics. His vast experience and in-depth knowledge of basic genetics and molecular biology in key cancer family syndromes are unparallel. He would closely supervise and guide on the development of this important volume in the series.

Davies, Mark
Mark Davies trained at The London Hospital Medical College. Having spent two years in research at the Royal Free Hospital, London he completed his higher surgical training in Cardiff, Swansea & Manchester. He was appointed as a Consultant Surgeon in Swansea in 2007 where he has developed an expertise in inflammatory bowel disease and colorectal cancer. Mr. Davies has a busy clinical practice in the broader aspects of colorectal surgery including minimal access surgery, colorectal cancer and proctology. He is a senior clinical tutor at Swansea University, Chair of the Colorectal Cancer National Specialty Advisory Group and a member of The Court of Examiners of The Royal College of Surgeons of England. He has extensively published and remains a committed surgical trainer and educator. Clinical interests Inflammatory bowel disease Colorectal cancer Abdominal wall hernias Minimal access surgery Proctology (Haemorrhoids, Fissure, Fistula etc) Research interests Colorectal Cancer Quality of life after surgery.