Bioreactor Modeling

Interactions Between Hydrodynamics and Biology
Erscheinungsjahr 2017
ISBN: 978-1-78548-116-1
Verlag: Elsevier Science

Buch, Englisch, 218 Seiten, Format (B × H): 236 mm x 162 mm, Gewicht: 480 g

Dynamic simulation of bioreactors is a challenge for both the industrial and academic worlds. Beyond the large number of physical and biological phenomena to be considered and the wide range of scales involved, the central difficulty lies in the need to account for the dynamic behavior of suspended microorganisms. In the case of chemical reactors, knowledge of the thermodynamic equilibrium laws at the interfaces makes it possible to produce macroscopic models by integrating local laws. Microorganisms, on the other hand, have the ability to modulate the rate of substrate assimilation. Moreover, the nature of the biochemical transformations results from a compromise between the needs of the cell and the available resources. This book revisits the modeling of bioreactors using a multi-scale approach. It addresses issues related to mixing, phase-to-phase transfers and the adaptation of microorganisms to variations in concentration, and explores the use of population balances for the simulation of bioreactors.By adopting a multidisciplinary perspective that draws on process engineering, fluid mechanics and microbiology, this book sheds new light on the particularity of bioprocesses in relation to physical and chemical phenomena.

Zielgruppe

Graduate, post graduate and reseachers in Bioprocess Engineering

Autoren/Hrsg.

Morchain, Jerome

Fachgebiete

• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Chemische Anlagen
• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Biotechnologie Industrielle Biotechnologie

Inhaltsverzeichnis

1. Basic Concepts for Bioreactor Modelling 2. Mixing, Transfer and Reaction 3. Flow Characterization and Particle Trajectory 4. From Average Cell to Population Balance Approach 5. Mechanical Interactions

Über Autor(innen)

Morchain, Jerome
Jérôme Morchain has been a process engineer and a lecturer at INSA Toulouse in France since 2003. He conducts research on the modeling of biological reactors at the Biosystems and Process Engineering Laboratory (LISBP).