Peroxisome Proliferators

1. Auflage 1994
ISBN: 978-0-8493-8305-2
Verlag: CRC Press

Buch, Englisch, 200 Seiten, Format (B × H): 178 mm x 254 mm, Gewicht: 589 g

Reihe: Handbooks in Pharmacology and Toxicology

Induction of drug (xenobiotic)-metabolizing enzymes is a common biological response to xenobiotics, the mechanisms and consequences of which are important in academic, industrial, and regulatory areas of pharmacology and toxicology. This monograph, for the first time, has brought together researchers who deal specifically with drug-metabolizing enzymes and peroxisome proliferators. It contains an up-to-date review of peroxisome proliferation, with detailed tables on the 100 known peroxisome proliferators and studies on their hepatocarcinogic capacity. It provides current material from 12 different laboratories doing cutting-edge research on the effect of peroxisome proliferators on drug-metabolizing enzymes.The book covers the response of cytochrome P450s, UDP-glucuronosyltransferases, epoxide hydrolases, glutathione S-transferase, DT-diaphorase, and other enzymes.

Zielgruppe

Professional

Autoren/Hrsg.

Moody, David E.

Weitere Mitwirkende

Hollinger, Mannfred A.

Hammock, Bruce D.

Okita, Richard T.

Johnson, Eric F.

Gibson, G. Gordon

Diaz, Maria J.

Chinje, Edwin

Kentish, Peter

Ortiz de Montellano, Paul R.

Kaikaus, Raja M.

Chan, William K.

Sui, Zhihua

Bass, Nathan M.

Hsu, Mei-Hui

Palmer, Colin N. A.

Magdalou, Jacques

Goudonnet, Herve

Fournel-Gigleux, Sylvie

Pritchard, Mike

Siest, Gerard

Grant, David F.

Beetham, Jeffrey K.

Storms, David H.

Moghaddam, Mehran F.

Borhan, Babak

Pinot, Franck M.

Winder, Bruce S.

Gill, Sarjeet S.

Chang, Cheng

DePierre, Joseph W.

Sohlenius, Anna-Karin

Eriksson, Anna Messing

Soderstrom, Mats

Permadi, Harnowo

Andersson, Karin

Sundberg, Carola

Lundgren, Bo

Budroe, John D.

Williams, Gary M.

Oesch, Franz

Arand, Michael

Rao, M. Sambasiva

Reddy, Janardan K.

Fachgebiete

• Naturwissenschaften Biowissenschaften Enzymologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie

Inhaltsverzeichnis

Peroxisome Proliferation: An Overview, D.E. MoodyInduction of Cytochromes P450 by Peroxisome Proliferators, G.G. Gibson, M.J. Diaz, E. Chinje, and P. KentishEffect of Peroxisome Proliferators on Microsomal P450 Reactions, R.T. OkitaInhibition of Cytochrome P450 4A Enzymes and Peroxisome Proliferation, P. Ortez de Montellano, R.M. Kaikaus, W.K. Chan, Z. Sui, and N.M. BassPeroxisome Proliferator Activated Receptor-Mediated Induction of P450 4A, E.F. Johnson, M.-H. Hsu, and C.N.A. PalmerUDP-Glucuronosyltransferases and Peroxisome Proliferators, J. Magdalou, S. Fournel-Gigleux, H. Goudonnet, M. Pritchard, and G. SiestThe Response of Soluble Epoxide Hydrolase and Other Hydrolytic Enzymes to Peroxisome Proliferators, D.F. Grant, D.E. Moody, J. Beetham, D.H. Storms, M.F. Moghaddam, B. Borhan, F. Pinot, B. Winder, and B.D. HammockPeroxisome Proliferation and the Subcellular Localization of Soluble Epoxide Hydrolase: Role of Peroxisomal Targeting Sequences, S.S. Gill, D.F. Grant, J.K. Beetham, and C. ChangResponses of Epoxide Hydrolases, Glutathoine S-Transferase, DT-Diaphorase and Catalase in Mouse Liver to Treatment with Peroxisome Proliferators, J.W. DePierre, A.-K. Sohlenius, A.M. Eriksson, M. Soderstrom, H. Permadi, K. Andersson, C. Sundberg, and B. LundgrenAnti-Oxidant Activity Modulation by Peroxisome Proliferators, J.D. Budroe and G.M. WilliamsInduction of Drug-Metabolizing Enzymes by Short/Intermediate-Term Exposure to Peroxisome Proliferators-A Synopsis, F. Oesch and M. ArandDrug Metabolizing Enzymes as Part of the Unique Phenotypic Properties of Peroxisome Proliferator-Induced Liver Tumors, M.S. Rao and J.K. Reddy).