Adhesion in Pharmaceutical, Biomedical, and Dental Fields

1. Auflage 2017
ISBN: 978-1-119-32350-1
Verlag: Wiley

Buch, Englisch, 432 Seiten, Format (B × H): 155 mm x 231 mm, Gewicht: 680 g

Reihe: Adhesion and Adhesives - Fundamental and Applied Aspects

The only book to cover adhesion in pharmaceutical, biomedical and dental fields

The phenomenon of adhesion is of cardinal importance in the pharmaceutical, biomedical and dental fields. A few eclectic examples will suffice to underscore the importance/relevance of adhesion in these three areas. For example, the adhesion between powdered solids is of crucial importance in tablet manufacture. The interaction between biodevices (e.g., stents, bio-implants) and body environment dictates the performance of such devices, and there is burgeoning research activity in modifying the surfaces of such implements to render them compatible with bodily components. In the field of dentistry, the modern trend is to shift from retaining of restorative materials by mechanical interlocking to adhesive bonding.

The book contains 15 chapters written by internationally-renowned subject matter experts and is divided into four parts: Part 1: General Topics; Part 2: Adhesion in Pharmaceutical Field; Part 3: Adhesion in Biomedical Field; and Part 4: Adhesion in Dental Field.

The topics covered include: Theories or mechanisms of adhesion; wettability of powders; role of surface free energy in tablet strength and powder flow behavior; mucoadhesive polymers for drug delivery systems; transdermal patches; skin adhesion in long-wear cosmetics; factors affecting microbial adhesion; biofouling and ways to mitigate it; adhesion of coatings on surgical tools and bio-implants; adhesion in fabrication of microarrays in clinical diagnostics; antibacterial polymers for dental adhesives and composites; evolution of dental adhesives; and testing of dental adhesive joints.

Autoren/Hrsg.

Mittal, K L

Etzler, F M

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Zahnmedizin
• Technische Wissenschaften Maschinenbau | Werkstoffkunde Produktionstechnik Schweißtechnik
• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Pharmazeutische Technologie
• Naturwissenschaften Chemie Chemie Allgemein Pharmazeutische Chemie, Medizinische Chemie

Inhaltsverzeichnis

Preface xv

Part 1 General Topics

1 Theories and Mechanisms of Adhesion in the Pharmaceutical, Biomedical and Dental Fields 3
Douglas J. Gardner

1.1 Introduction 4

1.2 Mechanisms of Adhesion 7

1.3 Summary 17

References 18

2 Wettability of Powders 23
Emil Chibowski, Lucyna Holysz and Aleksandra Szczes

2.1 Introduction 23

2.2 Different Forms of Wetting 24

2.3 Hydrophilic and Hydrophobic Surfaces 27

2.4 Contact Angle Measurement in Wettability Studies of  Powdered Materials 27

2.5 Contact Angle and Surface Free Energy 35

2.6 Surface Free Energy Determination of Powdered Solids by Thin Layer Wicking Method 38

2.7 Surface Free Energy Determination of Powdered Solids by Imbibition Drainage Method 42

2.8 Summary 44

Acknowledgement 44

References 44

Part 2 Adhesion in the Pharmaceutical Field

3 Tablet Tensile Strength: Role of Surface Free Energy 53
Frank M. Etzler and Sorana Pisano

3.1 Introduction 54

3.2 Applicability of the Proposed Model to Pharmaceutical Materials 60

3.3 Discussion 70

3.4 Summary 72

3.5 Acknowledgements 72

References 72

4 Role of Surface Free Energy in Powder Behavior and Tablet Strength 75
Changquan Calvin Sun

4.1 Introduction 75

4.2 Surface Free Energy 76

4.3 Role of Surface Free Energy in Solid Wetting 77

4.4 Role of Surface Free Energy in Powder Flow 80

4.5 Role of Surface Free Energy in Powder Tableting 82

4.6 Concluding Remarks 84

References 84

5 Mucoadhesive Polymers for Drug Delivery Systems 89
Inderbir Singh, Pravin Pawar, Ebunoluwa A. Sanusi and Oluwatoyin A. Odeku

5.1 Introduction 90

5.2 Mucoadhesive Drug Delivery Systems 93

5.3 Mucoadhesive Polymers 95

5.4 Summary 107

References 108

6 Transdermal Patches: An Overview 115

Über Autor(innen)

Kashmiri Lal Mittal was employed by the IBM Corporation from 1972 through 1993 Currently, he is teaching and consulting worldwide in the broad areas of adhesion as well as surface cleaning. He is the editor of more than 135 books and the Founding Editor of the journal Reviews of Adhesion and Adhesives.

Frank Etzler earned his PhD in physical chemistry from the University of Miami. He is currently an Associate Professor of Pharmaceutics in the School of Pharmacy at the Lake Erie College of Osteopathic Medicine (LECOM).