Meyer | IMRT, IGRT, SBRT | E-Book | sack.de
E-Book

E-Book, Englisch, Band 43, 506 Seiten

Reihe: Frontiers of Radiation Therapy and Oncology

Meyer IMRT, IGRT, SBRT


Advances in the Treatment Planning and Delivery of Radiotherapy.

E-Book, Englisch, Band 43, 506 Seiten

Reihe: Frontiers of Radiation Therapy and Oncology

ISBN: 978-3-8055-9681-7
Verlag: S. Karger
Format: PDF
 Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

Over the last 4 years, IMRT, IGRT, SBRT: Advances in the Treatment Planning and Delivery of Radiotherapy has become a standard reference in the field. During this time, however, significant progress in high-precision technologies for the planning and delivery of radiotherapy in cancer treatment has called for a second edition to include these new developments. Thoroughly updated and extended, this new edition offers a comprehensive guide and overview of these new technologies and the many clinical treatment programs that bring them into practical use. Advances in intensity-modulated radiotherapy (IMRT), and 4D and adaptive treatment planning are clearly presented. Target localization and image-guided radiotherapy (IGRT) systems are comprehensively reviewed as well. Clinical tutorials illustrate target definitions for the major cancer sites, and useful techniques for organ motion management are described and compared. There are also several chapters that explore the technical basis and latest clinical experience with stereotactic body radiotherapy (SBRT) and summarize practical treatment recommendations. Furthermore, the significant and increasing contributions of proton therapy to cancer care are also highlighted, alongside the practical allocation of all these new technologies from an economic perspective. As a highlight of this volume, a number of images can be viewed online in time-elapse videos for greater clarity and more dynamic visualization Written by leading authorities in the field, this comprehensive volume brings clinical and technical practitioners of radiotherapy fully up to date with the key developments in equipment, technologies and treatment guidelines.
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Autoren/Hrsg.

Meyer
Meyer, J.L.

Fachgebiete

Weitere Infos & Material

1;Cover;1
2;Contents;6
3;Preface;10
4;Introduction;12
4.1;Advances in the Planning and Delivery of Radiotherapy: New Expectations, New Standards of Care;12
4.1.1;Abstract;12
4.1.2;The Expansion of Radiation Oncology Technologies;12
4.1.3;Target Volume Specification and Treatment: Issues of Accuracy;16
4.1.4;Intensity-Modulated Radiation Therapy/Image-Guided Radiation Therapy Planning and Delivery Technologies: Current Challenges;19
4.1.5;Proton and Heavy Ion Radiation Therapy;30
4.1.6;Radiation Dose and Second Cancers;32
4.1.7;Radiation Oncology Informatics;34
4.1.8;Conclusions;35
4.1.9;References;37
5;General Concepts and Methods;40
5.1;Advanced Technologies in the Radiotherapy Clinic: System Fundamentals;40
5.1.1;Abstract;40
5.1.2;A Typical Intensity-Modulated Radiotherapy Treatment Planning System;41
5.1.3;Target Localization and Image Guidance;43
5.1.4;Image Registration;52
5.1.5;Adaptive Radiotherapy;61
5.1.6;References;66
6;Economic Perspectives;71
6.1;Controversies in the Adoption of New Healthcare Technologies;71
6.1.1;Abstract;71
6.1.2;Health Technology Assessment;71
6.1.3;Payment Policy Development: Past and Present Realities, and Future Uncertainties;77
6.1.4;Cost-Effectiveness Methodologies, Implications in an Era of Value-Based Purchasing;83
6.1.5;Conclusions;88
6.1.6;References;89
7;IMRT: Advances in Treatment Design and Delivery;91
7.1;Clinical Implementation of Intensity-Modulated Arc Therapy;91
7.1.1;Abstract;91
7.1.2;Intensity-Modulated Arc Therapy: Basic Concepts;92
7.1.3;Why Rotational Intensity-Modulated Radiation Therapy?;93
7.1.4;Commercial Intensity-Modulated Arc Therapy Solutions;96
7.1.5;Clinical Implementation of Intensity-Modulated Arc Therapy;99
7.1.6;References;108
8;IGRT: Advances in Targeting Therapy;110
8.1;4D Imaging and 4D Radiation Therapy: A New Era of Therapy Design and Delivery;110
8.1.1;Abstract;110
8.1.2;Impact of Breathing Motion on Images;111
8.1.3;Impact of Breathing Motion during Treatments;117
8.1.4;Methods to Account for Breathing Motion;120
8.1.5;Future Directions;126
8.1.6;Acknowledgements;127
8.1.7;References;127
8.2;Locating and Targeting Moving Tumors with Radiation Beams;129
8.2.1;Abstract;129
8.2.2;How Do We Locate the Moving Target?;133
8.2.3;How Do We Hit a Moving Target?;137
8.2.4;How Do We Create Integrated Systems to Locate and Hit Moving Targets?;139
8.2.5;Conclusions;139
8.2.6;References;140
9;Integrating IMRT and IGRT into Treatment Delivery;143
9.1;Technologies of Image Guidance and the Development of Advanced Linear Accelerator Systems for Radiotherapy;143
9.1.1;Abstract;143
9.1.2;Technologies to Meet the Goals of Image-Guided Radiation Therapy;146
9.1.3;Image Guidance Systems and Procedures;148
9.1.4;Cone-Beam CT for Linac-Based Image-Guided Radiation Therapy;154
9.1.5;Image Guidance: Meeting Future Needs;165
9.1.6;Conclusions;169
9.1.7;References;169
9.2;HelicalTomotherapy: Image-Guided and Adaptive Radiotherapy;176
9.2.1;Abstract;176
9.2.2;System Overview;177
9.2.3;Clinical Applications of Helical Tomotherapy;178
9.2.4;Daily Megavoltage-Based CT Imaging;179
9.2.5;Dose Evaluation and Adaptive Radiotherapy;186
9.2.6;Conclusions;190
9.2.7;References;190
9.3;The CyberKnife in Clinical Use: Current Roles, Future Expectations;192
9.3.1;Abstract;192
9.3.2;The CyberKnife System;192
9.3.3;Advances in CyberKnife Treatment Planning and Dose Delivery;194
9.3.4;Current Clinical Applications of CyberKnife;199
9.3.5;The Future of CyberKnife;202
9.3.6;References;203
10;Image Guidance and the New Practice of Radiotherapy: What to Know and Use from a Decade of Investigation;207
10.1;Abstract;207
10.2;The Rationale for Image-Guided Radiation Therapy: Perspectives on the Current Practice of Radiotherapy;207
10.3;Challenges in Image-Guided Radiation Therapy;213
10.4;Clinical Applications of Image-Guided Radiation Therapy;217
10.5;Adaptive Radiotherapy;223
10.6;Conclusions;225
10.7;References;226
11;Head and Neck Cancers;228
11.1;Intensity-Modulated and Image-Guided Radiation Therapy for Head and Neck Cancers;228
11.1.1;Abstract;228
11.1.2;Intensity-Modulated Radiation Therapy/Image-Guided Radiation Therapy Planning for Head and Neck Cancers;229
11.1.3;Intensity-Modulated Radiation Therapy for Nasopharyngeal Carcinomas;245
11.1.4;Intensity-Modulated Radiation Therapy for Oropharyngeal Carcinomas;256
11.1.5;Conclusions;260
11.1.6;Guidelines for Clinical Practice;261
11.1.7;References;262
11.2;Delineating Neck Targets for Intensity-Modulated Radiation Therapy of Head and Neck Cancer;266
11.2.1;Abstract;266
11.2.2;Tumor and Target Volumes in the Neck;267
11.2.3;Target Doses and Techniques;275
11.2.4;Case Studies;278
11.2.5;Guidelines for Clinical Practice;278
11.2.6;References;280
12;Thoracic Cancers;282
12.1;Motion Management and Image Guidance for Thoracic Tumor Radiotherapy: Clinical Treatment Programs;282
12.1.1;Abstract;282
12.1.2;Practical Strategies for Managing Respiratory Motion;283
12.1.3;Case Example: Clinical Procedures for Respiratory Gating;298
12.1.4;References;302
13;Breast Cancer;303
13.1;Intensity-Modulated Radiotherapy for Breast Cancer: Advances in Whole and Partial Breast Treatment;303
13.1.1;Abstract;303
13.1.2;Intensity-Modulated Radiotherapy and the Goals of Breast Radiotherapy;303
13.1.3;Improving Dose Homogeneity;305
13.1.4;Avoidance of Organs at Risk;308
13.1.5;Clinical Treatment Planning;311
13.1.6;Partial Breast Radiotherapy;315
13.1.7;Intensity-Modulated Radiotherapy and Partial Breast Irradiation;319
13.1.8;Guidelines for Clinical Practice;322
13.1.9;References;323
14;Abdominal Cancers;326
14.1;Image-Guided Radiotherapy Strategies in Upper Gastrointestinal Malignancies;326
14.1.1;Abstract;326
14.1.2;Immobilization and Motion Management in Upper Abdominal Malignancies;327
14.1.3;Image-Guided Radiotherapy for Pancreatic Cancer;328
14.1.4;Image-Guided Radiotherapy for Liver Cancer;336
14.1.5;Conclusions;338
14.1.6;Guidelines for Clinical Practice;339
14.1.7;Acknowledgements;340
14.1.8;References;340
15;Lymphomas;342
15.1;Radiotherapy Planning for the Lymphomas: Expanding Roles for Biologic Imaging;342
15.1.1;Abstract;342
15.1.2;Initial Staging;343
15.1.3;Response Evaluation;345
15.1.4;Radiation Therapy Planning;348
15.1.5;Clinical Trials Utilizing PET;352
15.1.6;Guidelines for Clinical Practice;353
15.1.7;References;354
16;Prostate Cancer;355
16.1;Image-Guided, Adaptive Radiotherapy of Prostate Cancer: Toward New Standards of Radiotherapy Practice;355
16.1.1;Abstract;355
16.1.2;Prostate Radiotherapy: A Model for Adaptive Image-Guided Radiotherapy;356
16.1.3;Dosimetric Impact of Motion in Prostate Radiotherapy;357
16.1.4;Solutions to Motion and Deformation in Prostate Image-Guided Radiotherapy;370
16.1.5;Guidelines for Clinical Practice;377
16.1.6;References;378
17;SBRT Advances;381
17.1;The Expanding Roles of Stereotactic Body Radiation Therapy and Oligofractionation: Toward a New Practice of Radiotherapy;381
17.1.1;Abstract;381
17.1.2;The Radiobiology of Stereotactic Body Radiation Therapy;382
17.1.3;Stereotactic Body Radiation Therapy Applications;385
17.1.4;Future Directions for Stereotactic Body Radiation Therapy;389
17.1.5;Conclusions;391
17.1.6;References;391
17.2;Stereotactic Body Radiation Therapy: Normal Tissue and Tumor Control Effects with Large Dose per Fraction;393
17.2.1;Abstract;393
17.2.2;Traditional Radiobiology;394
17.2.3;Modeling the Survival Curve;396
17.2.4;Biologically Equivalent Dose;397
17.2.5;Organ/Tissue Function and Microscopic Architecture;398
17.2.6;Serially Functioning Tissue Macroscopic Architecture;401
17.2.7;Stereotactic Body Radiation Therapy and Ablation;402
17.2.8;Normal Tissue Consequences of Ablative Dose Delivery;403
17.2.9;Tumor Control Dose;404
17.2.10;Conclusions;404
17.2.11;References;405
18;Thoracic Cancers;406
18.1;Stereotactic Body Radiation Therapy for Thoracic Cancers: Recommendations for Patient Selection, Setup and Therapy;406
18.1.1;Abstract;406
18.1.2;Prospective Testing of Stereotactic Body Radiation Therapy;407
18.1.3;A Guide to Stereotactic Body Radiation Therapy: Procedures and Practice;411
18.1.4;Guidelines for Clinical Practice;421
18.1.5;References;421
19;Gastrointestinal Cancers;423
19.1;Stereotactic Body Radiation Therapy for Gastrointestinal Malignancies;423
19.1.1;Abstract;423
19.1.2;Stereotactic Body Radiotherapy for Locally Advanced Pancreatic Cancers;424
19.1.3;Stereotactic Body Radiotherapy for Hepatic Malignancies;432
19.1.4;Guidelines for Clinical Practice;436
19.1.5;References;437
20;Genitourinary Cancers;439
20.1;Stereotactic Body Radiotherapy for Prostate Cancer: Current Results of a Phase II Trial;439
20.1.1;Abstract;439
20.1.2;Phase II Trial for Hypofractionated Radiotherapy of Prostate Cancer;439
20.1.3;Trial Results;444
20.1.4;Guidelines for Clinical Care;448
20.1.5;References;448
21;Techniques and Technologies;449
22;Proton Therapy: Clinical Gains through Current and Future Treatment Programs;449
22.1;Abstract;449
22.2;The State of the Art in Proton Therapy;451
22.3;Current and Future Developments in Clinical Proton Technology;460
22.4;Conclusions: Future Proton Technologies;472
22.5;References;473
23;Medical Applications and Advances;474
23.1;Proton Therapy in the Clinic;474
23.2;Abstract;474
23.3;Rationale for Protons;475
23.4;Protons: Clinical Advantages and Special Concerns;475
23.5;Proton Radiotherapy Treatment Planning;479
23.6;Issues in the Utilization of Proton Radiotherapy;482
23.7;Protons: Clinical Experience;484
23.8;Protons: How User Friendly?;489
23.9;Protons: Current Challenges;491
23.10;Guidelines for Clinical Practice;493
23.11;References;493
24;Author Index;495
25;Subject Index;496

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