Mestecky / Lamm / Ogra Mucosal Immunology

3. Auflage 2005
ISBN: 978-0-08-045426-9
Verlag: Elsevier Science & Techn.
Format: EPUB
Kopierschutz: 6 - ePub Watermark

E-Book, Englisch, 2064 Seiten

Mucosal immunology is so important since most infectious agents enter the body through the various mucous membranes, and many common infections take place in or on mucous membranes. Mucosal Immunology, now in its third edition, is the only comprehensive reference covering the basic science and clinical manifestations of mucosal immunology. This book contains new research data, exceptional illustrations, original theory, a new perspective and excellent organization. - The most comprehensive text on mucosal immunology from internationally recognized experts in the field - Includes exceptional color illustrations, new research data, original theory and information on all mucosal diseases - Contains nine new chapters and an expanded appendix

Autoren/Hrsg.

Mestecky, Jiri

Lamm, Michael E.

Ogra, Pearay L.

Strober, Warren

Bienenstock, John

Mcghee, Jerry R.

Mayer, Lloyd

Inhaltsverzeichnis

1;front cover;1
2;copyright;5
3;front matter;6
4;Preface to the First Edition;10
5;Preface to the Second Edition;12
6;Preface to the Third Edition;14
7;Contributors;16
8;table of contents;28
9;Historical Aspects of Mucosal Immunology;34
10;body;58
11;Part I Mucosal Immune System;58
11.1;Section A Mucosal Barrier: Development and Physiology of Mucosal Defense;60
11.1.1;1 Development and Physiology of Mucosal Defense: An Introduction;62
11.1.2;2 Mucosal Microbiota;76
11.1.3;3 Adhesion of Bacteria to Mucosal Surfaces;92
11.1.4;4 Mucus;106
11.1.5;5 Innate Humoral Defense Factors;130
11.1.6;6 Defensins and Other Antimicrobial Peptides and Proteins;152
11.1.7;7 Cellular and Molecular Basis for Antigen Transport Across Epithelial Barriers;168
11.1.8;8 Structure and Function of Intestinal Mucosal Epithelium;188
11.1.9;9 Mucosal Immunoglobulins;210
11.1.10;10 Organization and Expression of Genes Encoding IgA Heavy Chain, Polymeric Ig Receptor, and J Chain;240
11.1.11;11 Phylogeny and Comparative Physiology of IgA;252
11.1.12;12 Immunoglobulin Transport and the Polymeric Immunoglobulin Receptor;268
11.1.13;13 Fc Receptors;308
11.1.14;14 Biological Activities of IgA;324
11.1.15;15 Microbial Evasion of IgA Functions;348
11.1.16;16 Ontogeny of Mucosal Immunity and Aging;362
11.1.17;17 Phylogeny of the Gut-Associated Lymphoid Tissue (GALT);380
11.1.18;18 The Role of Mucosal Microbiota in the Development, Maintenance, and Pathologies of the Mucosal Immune System;392
11.2;Section B Inductive and Effector Tissues and Cells of the Mucosal Immune System;426
11.2.1;19 Inductive and Effector Tissues and Cells of the Mucosal Immune System: An Overview;428
11.2.2;20 Bronchus-Associated Lymphoid Tissues;432
11.2.3;21 Development and Function of Organized Gut-Associated Lymphoid Tissues;442
11.2.4;22 Human Gut-Associated Lymphoid Tissues;464
11.2.5;23 Nasal-Associated Lymphoid Tissue;472
11.2.6;24 Role of Epithelium in Mucosal Immunity;480
11.2.7;25 Role of Epithelial Cells in Mucosal Antigen Presentation;492
11.2.8;26 Antigen Handling and Presentation by Mucosal Dendritic Cells and Macrophages;508
11.2.9;27 Oral Tolerance: Physiologic Basis and Clinical Applications;544
11.2.10;28 Th1/Th2/Th3 Cells for Regulation of Mucosal Immunity, Tolerance, and Inflammation;596
11.2.11;29 Cytotoxic T Cells of the Mucosal Immune System;616
11.2.12;30 Development, Function, and Specificity of Intestinal Intraepithelial Lymphocytes;622
11.2.13;31 IgA B Cell Development;640
11.2.14;32 The Human Mucosal B-Cell System;674
11.2.15;33 B-1 Cells and the Mucosal Immune System;712
11.2.16;34 Lymphocyte Homing: Chemokines and Adhesion Molecules in T cell and IgA Plasma Cell Localization in the Mucosal Immune System;724
11.2.17;35 Proinflammatory Cytokines and Signaling Pathways in Intestinal Innate Immune Cells;738
11.2.18;36 Mast Cells In Mucosal Defenses and Pathogenesis;760
11.2.19;37 Eosinophils;774
11.2.20;38 Neuropeptides for Mucosal Immunity;794
11.3;Section C Mucosal Immunity and Infection;806
11.3.1;39 Mucosal Immunity and Infection: An Overview;808
11.3.2;40 Bacterial Interactions with Mucosal Epithelial Cells;810
11.3.3;41 Virus Infection of Epithelial Cells;826
11.3.4;42 Mucosal Immunity to Bacteria;840
11.3.5;43 Mucosal Immunity to Viruses;856
11.3.6;44 Mucosal Immune Response to Parasitic Infections;872
11.3.7;45 Parenteral Immunization Induces Mucosal Protection: A Challenge to the Mucosal Immunity Paradigm;888
11.3.8;46 Passive Immunization: Systemic and Mucosal;898
11.4;Section D Mucosal Vaccines;910
11.4.1;47 Mucosal Vaccines: An Overview;912
11.4.2;48 Enteric Bacterial Vaccines: Salmonella, Shigella, Vibrio cholerae, Escherichia coli;932
11.4.3;49 Viral Gastroenteritis Vaccines;944
11.4.4;50 Respiratory Bacterial Vaccines;962
11.4.5;51 Respiratory Viral Vaccines;980
11.4.6;52 Mucosal Immunity and Vaccines Against Simian Immunodeficiency Virus and Human Immunodeficiency Virus;994
11.4.7;53 CpG Oligodeoxynucleotides for Mucosal Vaccines;1016
11.4.8;54 Mucosal Adjuvants;1024
11.4.9;55 Antigen Delivery Systems I: Nonliving Microparticles, Liposomes, and Immune Stimulating Complexes (ISCOMs);1044
11.4.10;56 Antigen Delivery Systems II: Development of Live Recombinant Attenuated Bacterial Antigen and DNA Vaccine Delivery Vector Vaccines;1066
11.4.11;57 Recombinant Live Viral Vectors as Vaccines for Mucosal Immunity;1096
11.4.12;58 Transgenic Plants for Mucosal Vaccines;1110
11.4.13;59 Antigen Delivery Systems III: Use of Recombinant Plant Viruses;1118
11.4.14;60 DNA Vaccines for Mucosal Immunity to Infectious Diseases;1130
11.4.15;61 Mucosal Veterinary Vaccines: Comparative Vaccinology;1142
11.4.16;62 Mucosal Vaccines for Dental Diseases;1166
12;Part II Mucosal Diseases;1196
12.1;Section E Immunodeficiency;1198
12.1.1;63 Immunodeficiency and Mucosal Immunity: An Overview;1200
12.1.2;64 Immunodeficiency and Mucosal Immunity;1202
12.1.3;65 Undernutrition, Immunodeficiency, and Mucosal Infections;1216
12.1.4;66 Mucosal Infection and Immune Responses to Simian Immunodeficiency Virus;1236
12.1.5;67 Immunobiology of Mucosal HIV-1 Infection;1256
12.2;Section F Stomach, Liver, and Intestine;1270
12.2.1;68 Mucosal Injury and Immunopathology: An Overview;1272
12.2.2;69 Peptic Ulcers and Gastritis;1276
12.2.3;70 Disease Induction and Prevention in Experimental Models of Inflammatory Bowel Disease;1294
12.2.4;71 Ulcerative Colitis: Evolving Insights into Pathogenesis;1312
12.2.5;72 Crohn's Disease: Current Pathogenetic Paradigms;1322
12.2.6;73 Protein-Losing Enteropathies;1344
12.2.7;74 Celiac Disease;1368
12.2.8;75 Food Allergy: Immunophysiology;1392
12.2.9;76 Allergic Diseases in the Gastrointestinal Tract;1408
12.2.10;77 Gastrointestinal Lymphoma;1418
12.2.11;78 Liver and Biliary Tract;1430
12.2.12;79 Systemic Manifestations of Mucosal Diseases: Trafficking of Gut Immune Cells to Joints and Liver;1446
12.3;Section G Respiratory Tract;1456
12.3.1;80 Mucosal and Other Mechanisms of Resistance in the Respiratory Tract: An Overview;1458
12.3.2;81 Experimental Models of Airway Hyperresponsiveness;1460
12.3.3;82 Asthma: Clinical Aspects and Mucosal Immunology;1472
12.3.4;83 Clinical Aspects of Bronchial Reactivity and Cell-Virus Interaction;1490
12.3.5;84 Immune Responses to Mycoplasma;1508
12.3.6;85 Local Immune Responses in Tuberculosis;1522
12.4;Section H Oral Cavity, Upper Airway, and Head and Neck;1532
12.4.1;86 Ocular Mucosal Immunity;1534
12.4.2;87 Nasal Immunologic Reactivity, Rhinitis, and Polyps;1554
12.4.3;88 Middle Ear and Eustachian Tube;1566
12.4.4;89 Immunology of Diseases of the Oral Cavity;1574
12.4.5;90 Immunobiology of the Tonsils and Adenoids;1604
12.5;Section I Genitourinary Tract and Mammary Gland;1630
12.5.1;91 Immunology and Immunopathology of the Genitourinary Tract: An Overview;1632
12.5.2;92 IgA Nephropathy and Related Diseases;1636
12.5.3;93 Urinary Tract Infections and the Mucosal Immune System;1658
12.5.4;94 Female Genital Tract Infections and Immunity in Animal Models;1670
12.5.5;95 Mucosal Immunity in the Human Female Reproductive Tract;1688
12.5.6;96 Human Male Genital Tract Immunity and Experimental Models;1704
12.5.7;97 Endocrine Regulation of the Mucosal Immune System in the Female Reproductive Tract;1718
12.5.8;98 Immunologically Mediated Male and Female Reproductive Failure;1734
12.5.9;99 Mucosal Immunology of Sexually Transmitted Diseases;1750
12.5.10;100 Maternal Genital Tract Infection and the Neonate;1778
12.5.11;101 Immunity at the Maternal-Fetal Interface;1792
12.5.12;102 Amniotic Fluid and the Fetal Mucosal Immune System;1804
12.5.13;103 Immunoglobulins and Immunocytes in the Mammary Gland and Its Secretions;1820
12.5.14;104 Human Milk: Its Components and Their Immunobiologic Functions;1852
13;back matter;1886
14;Appendix I Collection and Processing of Human Mucosal Secretions;1886
15;Appendix II Collection and Processing of External Secretions and Tissues of Mouse Origin;1898
16;Appendix III Collection, Handling, and Analysis of Specimens for Studies of Mucosal Immunity in Large Animals;1910
17;Abbreviations;1926
18;index;1928
19;Color Plates;1976

Leseproben

Contributors Mohammed D. Abd-Alla Department of Medicine, University of Minnesota, Minneapolis, Minnesota Soman N. Abraham Departments of Pathology and Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina David Adams Liver Research Laboratories, University of Birmingham, Institute of Clinical Science, MRC Centre for Immune Regulation, Queen Elizabeth Hospital, Edgbaston, Birmingham, United Kingdom Deborah J. Anderson Fearing Research Laboratory, Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham Women’s Hospital, Harvard Medical School, Boston, Massachusetts Charles J. Arntzen Arizona State University Biodesign Institute and School of Life Sciences, Tempe, Arizona T. Prescott Atkinson Department of Pediatrics, Division of Pediatric Allergy, University of Alabama at Birmingham, Birmingham, Alabama Espen S. Baekkevold Laboratory for Immunohistochemistry and Immunopathology (LIIPAT), Institute of Pathology, University of Oslo, The National Hospital, Rikshospitalet, Oslo, Norway A. Dean Befus Pulmonary Research Group, Department of Medicine, Faculty of Medicine, University of Alberta, Edmonton, Alberta, Canada Lesley Ann Bergmeier Guy’s, Kings, and St. Thomas’ Medical and Dental Schools, London, United Kingdom Göran Bergsten Department of Medical Microbiology, University of Lund, Lund, Sweden M. Cecilia Berin Department of Pediatrics, Mount Sinai School of Medicine, New York, New York Joel M. Bernstein Department of Otolaryngology and Pediatrics, State University of New York at Buffalo, School of Biomedical Sciences, Buffalo, New York Charles L. Bevins Departments of Immunology, Gastroenterology, and Colorectal Surgery, The Cleveland Clinic Foundation Research Institute, Cleveland, Ohio John Bienenstock Departments of Medicine & Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada Brian L. Bishop Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina Jan Bjersing Department of Rheumatology and Inflammation Research, Göteborg University, Göteborg, Sweden Richard S. Blumberg Division of Gastroenterology, Harvard Medical School, Brigham Women’s Hospital, Boston, Massachusetts Libuse A. Bobek Department of Oral Biology, University at Buffalo, Buffalo, New York Nadiya Boiko Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania Department of Genetics and Plant Physiology, Uzhhorod National University, Uzhhorod, Ukraine Nicolaas A. Bos Department of Cell Biology, Immunology Section, University of Groningen, Groningen, The Netherlands Kenneth L. Bost Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina Prosper N. Boyaka Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama Per Brandtzaeg Laboratory for Immunohistochemistry and Immunopathology (LIIPAT), Institute of Pathololgy, University of Oslo, The National Hospital, Rikshospitalet, Oslo, Norway David E. Briles Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama Jeremy H. Brock Department of Immunology, University of Glasgow, Glasgow, Scotland Richard A. Bronson Department of Obstetrics and Gynecology, Stony Brook Health Science Center, Stony Brook, New York William R. Brown Department of Gastroenterology, University of Colorado School of Medicine, Denver, Colorado Mark G. Buckley Allergy and Inflammation Research, Division of Infection, Inflammation, and Repair, School of Medicine, University of Southampton, Southampton, United Kingdom Eugene C. Butcher Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, California The Center for Molecular Biology and Medicine, The Veterans Affairs Palo Alto Health Care System, Palo Alto, California John E. Butler Department of Microbiology and Interdisciplinary Immunology Program, The University of Iowa, Iowa City, Iowa Hege S. Carlsen Laboratory for Immunohistochemistry and Immunopathology (LIIPAT), Institute of Pathololgy, University of Oslo, The National Hospital, Rikshospitalet, Oslo, Norway Gail H. Cassell Infectious Disease Drug Discovery Research and Clinical Investigation, Lilly Research Laboratories, Indianapolis, Indiana Sabina Cauci Department of Biomedical Sciences and Technologies, University of Udine, Udine, Italy John J. Cebra Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania Stephen J. Challacombe Department of Oral Medicine and Pathology, Guy’s Hospital, London, United Kingdom Hilde Cheroutre La Jolla Institute for Allergy & Immunology, San Diego, California Rachel Chikwamba Arizona State University Biodesign Institute and School of Life Sciences, Tempe, Arizona Noel K. Childers Department of Oral Biology, University of Alabama at Birmingham, Birmingham, Alabama Robert L. Clancy Department of Pathology, University of Newcastle, Newcastle, New South Wales, Australia Richard W. Compans Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia Richard A. Cone Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, Maryland Lynette B. Corbeil Department of Pathology, UCSD Medical Center, University of California at San Diego, San Diego, California Mardi A. Crane-Godreau Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire Allan W. Cripps School of Medicine, Griffith University, Queensland, Australia Charlotte Cunningham-Rundles Division of Clinical Immunobiology, Mount Sinai School of Medicine, New York, New York Roy Curtiss, III. Biodesign Institute and School of Life Sciences, Arizona State University, Tempe, Arizona Cecil Czerkinsky Faculte de Medecine-Pasteur, Universite de Nice, Nice, France Steven J. Czinn Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio Ype de Jong Division of Immunology, Beth Israel Hospital, Boston, Massachusetts Gordon Dent Centre for Molecular Biomedicine, School of Life Sciences, Keele University, Keele, United Kingdom Mark T. Dertzbaugh United States Army Medical Research Institute of Infectious Disease, Fort Detrick, Maryland Victor J. DiRita Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan Rainer Duchmann Medical Department, Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Free University of Berlin, Berlin, Germany Charles O. Elson Division of Gastroenterology and Hepatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama Steven N. Emancipator Department of Pathology, Case Western Reserve University, Cleveland, Ohio Mary K. Estes Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas Sidonia Fargarasan Laboratory of Mucosal Immunology, RIKEN Research Centre for Allergy and Immunology, Yokohama City, Japan Ana M.C. Faria Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil Inger Nina Farstad Laboratory for Immunohistochemistry and Immunopathology (LIIPAT), Institute of Pathololgy, University of Oslo, The National Hospital, Rikshospitalet, Oslo, Norway Paul L. Fidel, Jr. Department of Microbiology, Louisiana State University Health Science Center, New Orleans, Louisiana Hans Fischer Department of Medical Microbiology, University of Lund, Lund, Sweden George Fogg Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, Michigan Kohtaro Fujihashi Departments of Oral Biology and Microbiology, and The Immunobiology Vaccine...