Buch, Englisch, 426 Seiten, Format (B × H): 160 mm x 241 mm, Gewicht: 903 g
Buch, Englisch, 426 Seiten, Format (B × H): 160 mm x 241 mm, Gewicht: 903 g
Reihe: Biology of Extracellular Matrix
ISBN: 978-3-642-16554-2
Verlag: Springer
Knowledge of the extracellular matrix (ECM) is essential to understand cellular differentiation, tissue development, and tissue remodeling.
This volume of the series “Biology of Extracellular Matrix” provides a timely overview of the structure, regulation, and function of the major macromolecules that make up the extracellular matrix. It covers topics such as collagen types and assembly of collagen-containing suprastructures, basement membrane, fibronectin and other cell-adhesive glycoproteins, proteoglycans , microfibrils, elastin, fibulins and matricellular proteins, such as thrombospondin. It also explores the concept that ECM components together with their cell surface receptors can be viewed as intricate nano-devices that allow cells to physically organize their 3-D-environment. Further, the role of the ECM in human disease and pathogenesis is discussed as well as the use of model organisms in elucidating ECM function.
Zielgruppe
Research
Autoren/Hrsg.
Weitere Infos & Material
An overview of extracellular matrix structure and function.- Fibronectin and other adhesive glycoproteins.- Collagen: suprastructures and collagen fibril assembly.- Asement membrane; Hyaluronan and the Aggregating Proteoglycans.- The small, leucine-rich proteoglycans.- Microfibrils and fibrillin.- Elastin.- Lysyl oxidase and lysyl oxidase-like enzymes.- The Fibulins.- Matricellular proteins.
