Buch, Englisch, 362 Seiten, Format (B × H): 157 mm x 234 mm, Gewicht: 676 g
Buch, Englisch, 362 Seiten, Format (B × H): 157 mm x 234 mm, Gewicht: 676 g
ISBN: 978-0-12-545090-4
Verlag: Elsevier Science
The chapters in this book thoroughly cover the structure, regulation, and function of matrix metalloproteinases, and provide information on the latest strategies to inhibit enzyme activity. This work will be an indispensable reference tool for investigators with an interest in extracellular matrix biology, matrix turnover, enzymology and biochemistry of proteinases, developmental biology, pathology, and therapeutic interventions.
Zielgruppe
AUDIENCE: Graduate students and researchers in cell biology, cancer biology, molecular biology, biochemistry departments. Scientists and physicians with an interest in the pathogenesis of cancer, arthritis, wound healing, and vascular disease. Researchers and product design scientists in the pharmaceutical and biotechnology industries.
Fachgebiete
Weitere Infos & Material
Contributors.
Preface.
The Matrix Metalloproteinase Family, J.F. Woessner, Jr.
Interstitial Collagenases, J.J. Jeffrey.
Stromelysins 1 and 2, H. Nagase.
72-kDa Gelatinase (Gelatinase A): Structure, Activation, Regulation, and Substrate Specificity, A.E. Yu, A.N. Murphy and W.G. Stetler-Stevenson.
Gelatinase B: Structure, Regulation, and Function, T.H. Vu and Z. Werb.
Matrilysin, C.L. Wilson and L.M. Matrisian.
Macrophage Elastase (MMP-12), S.D. Shapiro and R.M. Senior.
Membrane-Type Matrix Metalloproteinases and Cell Surface-Associated Activation Cascades for Matrix Metalloproteinases, V. Knauper and G. Murphy.
Substrate Specificity and Mechanism of Substrate Recognition of the Matrix Metalloproteinases, V. Imper and H.E. Van Wart.
Synthetic Inhibitors of Matrix Metalloproteinases, P.D. Brown.
Matrix Metalloproteinases in Tissue Repair, W.C. Parks, B.D. Sudbeck, G.R. Doyle and U.K. Saariahlo-Kere.
Regulation of Matrix Metalloproteinase Gene Expression, M.E. Fini, J.R. Cook, R. Mohan and C.E. Brinckerhoff.
Index.
