McCandless Kernicterus

1. Auflage 2010
ISBN: 978-1-4419-6555-4
Verlag: Humana Press
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 286 Seiten

Reihe: Contemporary Clinical Neuroscience

Kernicterus (bilirubin encephalopathy) is a highly interesting example of metabolic encephalopathy. It fills all the characteristics of a metabolic encephalopathy in that it can develop rapidly, produces signature signs and symptoms, and is amenable to successful treatment. In the absence of treatment kernicterus can produce devastating sequelae and death. The present volume will examine the biochemistry and physiology of bilirubin as well as its hepatic metabolism and renal excretion. Chapters will elaborate bodily disposition of bilirubin and its neuropathology. Both early treatments and current therapy will be discussed in detail. Phototherapy will be presented, and its efficacy and influence on incidence thoroughly examined.

Autoren/Hrsg.

McCandless, David W.

Inhaltsverzeichnis

1;Preface;5
2;Acknowledgements;8
3;Contents;9
4;Prologue: World Health Concerns;11
5;History of Bilirubin;20
6;Biochemistry and Physiology of Bilirubin;27
7;Premature Birth;40
8;Erythroblastosis Fetalis;49
9;The Gunn Rat Model;57
10;CriglerNajjar Syndrome;71
11;Neuropathology of Kernicterus;86
12;Bilirubin and Energy Metabolism;99
13;Jaundice and Other Biochemical Changes;113
14;Breast Milk Jaundice;119
15;Jaundice in Malaria;125
16;Jaundice in Congenital Hypertrophic Pyloric Stenosis;136
17;Phototherapy for Hyperbilirubinemia;143
18;Non-phototherapy Treatment;154
19;Hyperbilirubinemia Revisited;162
20;Auditory Brainstem Response;175
21;Progressive Familial Intrahepatic Cholestasis;188
22;Kernicterus in Older Children and Adults;201
23;Cerebral Palsy and Counseling;207
24;Neurological Sequelae from Jaundice;216
25;Neurobehavioral Teratology;224
26;Gene Therapy for Hyperbilirubinemia;232
27;Epilogue: Comments and Future Directions;242
28;Appendix Sources;248
29;References;250
30;Index;269