Mattson Membrane Microdomain Signaling

Lipid Rafts in Biology and Medicine
1. Auflage 2007
ISBN: 978-1-59259-803-8
Verlag: Humana Press
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 214 Seiten

Cutting-edge articles review our current understanding of lipid microdomain signaling mechanisms and their physiological and pathological importance. The book describes the role of lipid rafts in learning, memory, and cancer, presents the emerging evidence that lipid rafts play critical roles in signaling pathways and the regulation of synaptic function in the nervous system, and shows how alterations in lipid raft metabolism are implicated in the pathogenesis of neurodegenerative disorders. Techniques are also described for the isolation of lipid rafts, the analysis of the lipid and protein components of lipid rafts, the imaging of lipid rafts in living cells, and the analysis of signal transduction in lipid rafts.

Autoren/Hrsg.

Mattson, Mark P.

Inhaltsverzeichnis

1;Preface;5
2;Contents;7
3;Contributors;8
4;From Intramolecular Asymmetries to Raft Assemblies;10
4.1;1. INTRODUCTION AND CLASSIFICATION;10
4.2;2. INTRAMOLECULAR ASYMMETRY;11
4.3;3. MOLECULAR DIVERSITY BETWEEN OUTER AND INNER LEAFLETS;17
4.4;4. MOLECULAR DIVERSITY WITHIN THE SINGLE LEAFLET;18
4.5;5. ON PROTEOMICS AND LIPIDOMICS;19
4.6;ACKNOWLEDGMENTS;19
4.7;REFERENCES;20
5;Regulatory Aspects of Membrane Microdomain (Raft) Dynamics in Live Cells;24
5.1;1. INTRODUCTION;24
5.2;2. BIOPHYSICAL METHODOLOGY TO DETECT AND CHARACTERIZE RAFT MICRODOMAINS: ACHIEVEMENTS, LIMITATIONS, AND CHALLENGES;25
5.3;3. HOW LARGE AND DYNAMIC ARE THE RAFTS?;31
5.4;4. MODULATION OF PLASMA MEMBRANE RAFTS: STRATEGIES TO STUDY RAFT FUNCTIONS;34
5.5;5. RAFT DYNAMICS IN LIVE CELLS: REGULATION BY EXTERNAL, MEMBRANE, AND CYTOSOLIC FACTORS;37
5.6;6. RAFTS AND THEIR DYNAMICS IN SPECIALIZED COMPLEX BIOLOGICAL STRUCTURES: THE IMMUNOLOGICAL SYNAPSES;46
5.7;7. CONCLUDING REMARKS;49
5.8;REFERENCES;49
6;Lipid Raft Membrane Skeletons;56
6.1;1. INTRODUCTION;56
6.2;2. ACTIN AND LIPID RAFTS;59
6.3;3. “ HEAVY” DETERGENT- RESISTANT MEMBRANES ( DRM- H);60
6.4;4. DRM- H MEMBRANE SKELETON ARCHITECTURE;62
6.5;5. “ DRM- H- LIKE” MEMBRANE SKELETONS IN OTHER CELL TYPES;65
6.6;6. OTHER DYNAMIC LIPID RAFT- ASSOCIATED MEMBRANE SKELETONS;66
6.7;7. LIPID RAFT MEMBRANE SKELETONS ASSOCIATED WITH “ STABLE” MEMBRANE DOMAINS;68
6.8;8. CONCLUDING REMARKS;69
6.9;REFERENCES;70
7;Role of Cholesterol in Membrane Microdomain Signaling;79
7.1;1. INTRODUCTION;79
7.2;2. STRUCTURAL PROPERTIES OF LIPID RAFTS;79
7.3;3. STRUCTURAL PROPERTIES OF CAVEOLAE;83
7.4;4. CROSSTALK BETWEEN CAVEOLAE AND LIPID RAFTS;86
7.5;5. CHOLESTEROL DEPENDENCE OF SIGNALING FROM CAVEOLAE;87
7.6;6. DYNAMIC REGULATION OF FC IN CAVEOLAE;89
7.7;7. SUMMARY;90
7.8;ACKNOWLEDGMENT;90
7.9;REFERENCES;91
8;Raft Lipid Metabolism in Relation to Alkyl- Lysophospholipid- Induced Apoptosis;98
8.1;1. INTRODUCTION;98
8.2;2. BIOPHYSICAL BASIS OF LIPID INTERACTIONS IN LIPID RAFTS;99
8.3;3. INTRACELLULAR TARGETS OF ALP;100
8.4;4. MECHANISM OF ALP INTERNALIZATION: ENDOCYTOSIS VIA LIPID RAFTS;101
8.5;5. ALP- RESISTANT CELLS HAVE ABERRANT LIPID RAFTS;104
8.6;6. THE ASSEMBLY OF A LIPID RAFT;106
8.7;7. OTHER IMPLICATIONS OF LIPID RAFTS IN APOPTOTIC SIGNALING;109
8.8;8. CONCLUSIONS AND PERSPECTIVES;111
8.9;REFERENCES;112
9;The Role of Lipid Rafts in Signal Transduction and Synaptic Plasticity of Neural Cells;120
9.1;1. INTRODUCTION;120
9.2;2. ROLE OF LIPID RAFTS IN NEURAL CELL INTERACTIONS;122
9.3;3. THE ROLE OF LIPID RAFTS IN NEURONA EXCITABILITY;125
9.4;4. OUTLOOK;127
9.5;REFERENCES;128
10;Role of Rafts in Virus Fusion and Budding;133
10.1;1. INTRODUCTION;133
10.2;2. ROLE OF RAFTS IN VIRUS ENTRY;135
10.3;3. ROLE OF RAFTS IN THE ENTRY OF BACTERIAL PATHOGENS AND TOXINS;139
10.4;4. ROLE OF RAFTS IN VIRUS ASSEMBLY AND BUDDING;139
10.5;5. ROLE OF RAFTS IN VIRAL REPLICATION AND PATHOGENESIS;141
10.6;6. WHY RAFTS?;142
10.7;REFERENCES;142
11;Alterations in Raft Lipid Metabolism in Aging and Neurodegenerative Disorders;149
11.1;1. INTRODUCTION;149
11.2;2. AGING;152
11.3;3. ISCHEMIC STROKE;153
11.4;4. ALZHEIMER’S DISEASE;156
11.5;5. AMYOTROPHIC LATERAL SCLEROSIS;157
11.6;6. HIV DEMENTIA;159
11.7;7. SUMMARY;162
11.8;REFERENCES;163
12;Caveolin and Cancer;167
12.1;1. INTRODUCTION;167
12.2;2. UPREGULATION OF CAVEOLIN EXPRESSION DURING CELL DIFFERENTIATION;168
12.3;3. CHANGES IN CAVEOLIN EXPRESSION IN ONCOGENE- TRANSFORMED CELLS, CANCER CELL LINES, AND TUMOR SAMPLES;168
12.4;4. EFFECTS OF CAVEOLIN- 1 EXPRESSION AND SUPPRESSION ON CANCER CELL BIOLOGY;176
12.5;5. EFFECTS OF CAVEOLIN- 1 GENE KNOCKOUT: IS CAVEOLIN- 1 A TUMOR SUPPRESSOR PROTEIN?;178
12.6;6. MECHANISMS OF ANTIPROLIFERATIVE ACTION OF CAVEOLIN- 1;180
12.7;7. MODULATION OF CELL DEATH AND SURVIVAL SIGNALS BY CAVEOLIN- 1;182
12.8;8. MECHANISMS OF ACTION OF CAVEOLIN- 1 IN APOPTOSIS AND SURVIVAL SIGNALING PATHWAYS;183
12.9;9. ROLE OF ENDOTHELIAL CAVEOLIN- 1 IN TUMOR ANGIOGENESIS AND TUMOR VASCULAR PERMEABILITY;184
12.10;10. CONCLUDING REMARKS;185
12.11;ACKNOWLEDGMENTS;187
12.12;REFERENCES;187
13;Dietary Modulation of Lipid Rafts;197
13.1;1. INTRODUCTION;197
13.2;2. DIETARY CHOLESTEROL;197
13.3;3. SPHINGOLIPIDS;201
13.4;4. OTHER DIETARY LIPIDS;202
13.5;5. OTHER DIETARY FACTORS;203
13.6;REFERENCES;204
14;Index;208