Mattison Computational Methods for Reproductive and Developmental Toxicology

Erscheinungsjahr 2015
ISBN: 978-1-4398-6108-0
Verlag: Taylor & Francis
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 344 Seiten

Reihe: QSAR in Environmental and Health Sciences

Building from the perspective of reproductive and developmental biology, this volume provides a timely, comprehensive overview of computational approaches in reproductive and developmental toxicology. The book reviews the complexity of reproductive and developmental processes and the large number of chemicals in the environment and in drug development to which adults of reproductive age are exposed or treated. It highlights the need to determine those that represent potential hazards and strategies for evaluating that information. The text includes legislative initiatives focusing on the identification of reproductive and developmental hazards while reducing use of animals.

Zielgruppe

Academia, industry and government regulators in toxicology, pharmacology, clinical therapeutics, obstetrics, pharmacokinetics, and drug development; upper-level undergraduates in toxicology and medicinal chemistry; graduates in pharmaceutical sciences, medicinal chemistry, pharmacology, toxicology and specialty areas in medical student training.

Autoren/Hrsg.

Mattison, Donald R.

Fachgebiete

• Naturwissenschaften Biowissenschaften Toxikologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Reproduktionsmedizin
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Wachstum, Entwicklung, Altern
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Naturwissenschaften Biowissenschaften Entwicklungsbiologie

Inhaltsverzeichnis

INTRODUCTION
Overview and Rationale for this Book, Donald R. Mattison
How are Reproductive and Developmental Toxicants Identified, Richard K. Miller, Paul Schaefer, Marleen van Gelder
Developmental Toxicity Impact on Drug Development, Karen Augustine Rauch, Patrick Weir
REACH and Environmental Chemicals, Tony Scialli, David Gee
REPRODUCTION AND DEVELOPMENT: BIOLOGICAL PROCESSES AND ENDPOINTS
Fertility and Pregnancy, Paul Foster, Ralf Kaptijn, Paulo M. Perin, Luc Multigner
Male Reproduction, N. Skakkebaek
Embryonic Development, Fetal Growth, Enrique M. Ostrea, Tracy Woodruff, Linda Guidice, Robyn Whyatt
Parturition, Roberto Romero
Infant, Child, Adolescent, Jorma Toppari, Lynn Goldman, Michelle Marcus
Juvenile Animal Studies, Mark Hurt
Life Course Health, Paul Wise, Lynn Goldman
REPRODUCTION AND DEVELOPMENT: BIOLOGICAL AND COMPUTATIONAL METHODS
Biological Assays - In Vivo/In Vitro Assays: Whole Animal Screens, Isolated Tissues, Organs, Cells, Specific Enzymes in Screening, Chris Austin, Bob Kavlock, Luc Muitigner
Chemical Characteristics which may be of Use in Predicting Reproductive and/or Developmental Toxicity, Chihae Yang
Systems Approaches for Integrating Developmental Biology and Toxicology:

Gestational Diabetes, Mary Hebert
Prematurity, Steve Caritis, Rich Beigi
Hypertension, Tom Easterling
Thyroid Disease, Scott Rivkees
Epidemiology Methods: What Human Data Are Available That May Inform This QSAR Search, Germaine Louis, Enrique Schisterman, Alan Wilcox, Mark Klebanoff, Jorn Olsen
Data Mining, Fredrica Staffa
REACH Including Read-Across and Grouping Vs. Reproductive and Developmental Toxicology, Andrew Worth, Mark Cronin
Quantitative Structure Analysis for Reproductive and Developmental Toxicology, Donald R. Mattison, Albert Cunningham, Chihae Yang
Statistical Approaches, Vincent Arena, Nancy Sussman, Sati Mazumdar,
Physiologically Based Pharmacokinetic Approaches for Dose/Exposure/Disposition, Amin Rostami
Datasets - Creating, Curating, Validating and Updating, Beth Julian
Datasets - Using Experimental Animal Developmental Toxicity Data to Create and Sharpen the Approach, Tom Knudson
Modeling Neurodevelopmental Endpoints, Judy Lakind, Mike Goodman
Predicting Across Species and Adverse Reproductive Developmental Side Effects, Cruz-Monteagudo
Placental Transport QSAR, M. Hewitt, T.J. Morck, Lisbeth E. Knudsen
QSAR Modeling of the Passage or Chemicals into Human Milk: Different Models Exist for Predicting Chemical Transfer in Human Milk, A. Agatonovic-Kustrin

Über Autor(innen)

Donald R. Mattison is Senior Advisor to the Director of the Eunice Kennedy Shriver National Institute of Child Health and Human Development.