Small Molecules in Oncology

Softcover Nachdruck of the original 3rd Auflage 2018
ISBN: 978-3-030-08257-4
Verlag: Springer International Publishing

Buch, Englisch, Band 211, 276 Seiten, Previously published in hardcover, Format (B × H): 155 mm x 235 mm, Gewicht: 435 g

Reihe: Recent Results in Cancer Research

This book, written by respected experts, discusses in detail the latest developments in targeted oncology therapy using small molecules. It covers a wide range of small molecules, including tyrosine kinase inhibitors, mTOR, MEK, PARP, and multikinase inhibitors, as well as cell cycle and NTRK interacting agents. For each molecule, aspects such as the chemical structure, mechanism of action, drug targets, drug interactions, preclinical studies, clinical trials, treatment applications, and toxicity are discussed.

Extensive research into the molecular mechanisms of cancer has heralded a new age of targeted therapy. The field of personalized cancer therapy is now growing rapidly, and the advances being made will mean significant changes in the treatment algorithms for cancer patients. Numerous novel targets that are crucial for the survival of cancer cells can be attacked by small molecules such as protein tyrosine kinase inhibitors. This book is the third edition of Small Molecules in Oncology, but has now been divided into two volumes, with the other volume focusing specifically on small molecules in hematology.

Zielgruppe

Professional/practitioner

Autoren/Hrsg.

Martens, Uwe M.

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Onkologie, Krebsforschung

Inhaltsverzeichnis

Erlotinib.- Lapatinib.- Sorafenib.- Regorafenib.- Crizotinib.- Cabozantinib.- Vemurafenib.- Trametinib.- Everolimus.- Vismodegib.- Larotrectinib.- Palbociclib.- Taselisib.- Cobimetinib.- Lenvatinib.- Afatinib.- Olaparib.- Gefitinib.- Ceritinib.

Über Autor(innen)

Uwe Martens, Prof. Dr. med., is chair of the Cancer Center Heilbronn-Franken and head of the Department of Hematology and Oncology at the SLK Clinic Heilbronn, which is an academic teaching hospital of the University of Heidelberg. He graduated in Medicine from the University of Freiburg and continued his medical and scientific training at the Medical University Center in Freiburg and at the BC Cancer Research Center in Vancouver. His scientific focus is the development of personalized cancer therapy and immunotherapy. He is a co-founder of the MOLIT Institute for Personalized Medicine at the science and technology park in Heilbronn, which aims to rapidly translate precision medicine into standard care.