Marshall / Morgan In Vivo Models of Inflammation

1999
ISBN: 978-3-0348-7775-6
Verlag: Springer
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 347 Seiten, eBook

Reihe: Progress in Inflammation Research

The purpose of this volume in the series Progress in Inflammation Research is to pro vide the biomedical researcher with a description of the state of the art of the devel opment and use of animal models of diseases with components of inflammation. Par ticularly highlighted are those models which can serve as in vivo correlates of diseases most commonly targeted for therapeutic intervention. The format is designed with the laboratory in mind; thus it provides detailed descriptions of the methodologies and uses of the most significant models. Also, new approaches to the development of future models in selected therapeutic areas have been highlighted. While emphasis is on the newest models, new information broadening our understanding of several well-known models of proven clinical utility is included. In addition, we have pro vided coverage of transgenic and gene transfer technologies which will undoubtedly serve as tools for many future approaches. Provocative comments on the cutting edge and future directions are meant to stimulate new thinking. Of course, it is important to recognize that the experimental use of animals for human benefit carries with it a solemn responsibility for the welfare of these animals. The reader is referred to the section on current regulations governing animal use which addresses this concern. To fulfill our purpose, the content is organized according to therapeutic areas with the associated models arranged in subcategories of each therapeutic area.

Zielgruppe

Research

Autoren/Hrsg.

Marshall, Lisa A.

Morgan, Douglas W.

Inhaltsverzeichnis

Rat models of arthritis: similarities, differences, advantages, and disadvantages in the identification of novel therapeutics.- Murine collagen induced arthritis.- Models of inflammatory processes in cancer.- Advances in stem cell research: use of stem cells in animal models of muscular dystrophy.- Gene transfer technology.- Transgenics.- Nanotechnology: Towards the detection and treatment of inflammatory diseases.- UK legislation of in vivo aspects in inflammation research.- Japanese guidelines and regulations for ethical animal experimentation.- United States guidelines and regulations in animal experimentation.- Asthma.- In vivo modelling systems for chronic obstructive pulmonary disease.- Murine models of allergen-induced airway hyperresponsiveness and inflammation.- Skin inflammatory disorders.- In vivo models of neurogenic inflammation.- Animal models of inflammatory bowel disease.- Preclinical models of vascular inflammation