Buch, Englisch, Band 2, 150 Seiten, PB, Format (B × H): 148 mm x 210 mm, Gewicht: 221 g
Reihe: Contributions in Systems Theory and Automatic Control, Otto-von-Guericke-Universität Magdeburg
A Systems Biology Perspective Towards Therapy Design
Buch, Englisch, Band 2, 150 Seiten, PB, Format (B × H): 148 mm x 210 mm, Gewicht: 221 g
Reihe: Contributions in Systems Theory and Automatic Control, Otto-von-Guericke-Universität Magdeburg
ISBN: 978-3-8440-0779-4
Verlag: Shaker
In this work, the author employs a systems biology approach to get a system-level understanding of the biological mechanisms driving the adaptive response of bone to increased/decreased mechanical loads. To this end, a mathematical model describing the adaptation of bone due to mechanical and chemical stimuli is developed and qualitatively validated. Novel set-based methods are employed to analyze the steady state effects of parameter uncertainty and robustness of the model. Furthermore, these set-based methods are used to explore the design of new treatments combining the beneficial effects of mechanical and non-mechanical agents for specific bone disorder conditions.
