Semisynthesis of Bioactive Compounds and their Biological Activities

Erscheinungsjahr 2023
ISBN: 978-0-443-15269-6
Verlag: Elsevier Science & Technology

Buch, Englisch, Format (B × H): 152 mm x 229 mm, Gewicht: 760 g

Semisynthesis of Bioactive Compounds and their Biological Activities explores the potential benefits of semisynthetic derivatives obtained from nature. Sections cover the natural distribution of parent compounds, semisynthesis and biological properties of semisynthetic derivatives, the applications of semisynthetic derivatives in diverse fields such as drug delivery, food production and medicine, an explanation of the current resistance mechanisms of antibiotics, clinical applications of semisynthetic analogues, the functions of plant alkaloids on human health, potential agricultural biotechnology in semisynthetic derivatives, and semisynthesis of natural products under greener conditions, this book provides a comprehensive resource on the topics presented.

Sections include information about alternative sources of energy and superior greener technologies (microwave, sonochemistry), alternative reaction media (water, supercritical CO2, ionic liquids) and alternative eco-friendly catalysts (biocatalysts). This book will be an excellent resource for academicians, researchers and students focusing on synthesis as well as the biological community and industry professionals in drug development.

Autoren/Hrsg.

Majhi, Sasadhar

Manickam, Sivakumar

Fachgebiete

• Naturwissenschaften Chemie Organische Chemie
• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)

Inhaltsverzeichnis

1. Introduction2. Semisynthesis of Antibiotics3. Semisynthesis of Alkaloids4. Semisynthesis of Flavones5. Semisynthesis of Lignans6. Semisynthesis of Phenolic Compounds7. Semisynthesis of Anthocyanins8. Semisynthesis of Natural Products at Room Temperature (R2)9. Semisynthesis of Natural Products under Greener Conditions10. Semisynthesis of Natural Products through Insertion of Oxygen Atom under Metal-free Conditions11. An adaptation of organic reactions in the bioactive compounds industry (R1)12. Regulatory aspects of the novel derivative as nutraceuticals (R1)13. Computational chemistry of Natural Product Analogues (R2)14. Semi-synthesis for neglected and tropical diseases (R2)

Über Autor(innen)

Manickam, Sivakumar
Professor Sivakumar Manickam is a Chemical Engineer with a specialization in the process engineering of nanomaterials, especially nanopharmaceuticals, and has over 25 years of experience in this field. He is currently working with the University of Technology Brunei (UTB), Brunei; before that, he worked at the University of Nottingham, International Campus in Malaysia. A major focus of his research is the development of cavitation-based reactors for the production of nanomaterials of technological importance, greener extraction of natural products, water treatment, development of pharmaceutical nanoemulsions, and use of novel carbon nanomaterials to develop biosensors for earlier diagnosis of cancer and diabetes. While at the University of Nottingham, he served in a variety of leadership roles, including Director of Research, Founding Director for the Centre for Nanotechnology and Advanced Materials, Head - Manufacturing and Industrial Research Division and Associate Dean for Research and Knowledge Exchange. He serves as Deputy Dean (Research) of the Faculty of Engineering at UTB. Over the course of his career, he has completed more than 20 industrial and government-funded projects and supervised more than 50 students in research projects. Throughout his career, he has published more than 250 peer-reviewed papers in journals and conferences. According to Scholar Google, he has a h-index of 59. In addition, he is also the Executive Editor of the Ultrasonics Sonochemistry Journal. His affiliations include service on the board of the Asia Oceania Sonochemical Society as well as the Fellow of the Higher Education Academy (UK) and the Fellow of the Royal Society of Chemistry (FRSC).

Majhi, Sasadhar
Sasadhar Majhi received B.Sc. (Honours) degree in Chemistry and M.Sc. (Organic specialization), both from Visva-Bharati (a Central University founded by Rabindranath Tagore, a Nobel laureate). He received M.Phil (Chemistry) in 2009 and obtained a PhD from Visva-Bharati University under the supervision of Prof. Goutam Brahmachari. Currently, he serves as the coordinator of the department of chemistry (UG & PG departments) of Triveni Devi Bhalotia College (Government Sponsored and Affiliated to the Kazi Nazrul University, Asansol, previously affiliated to the Burdwan University), Raniganj, West Bengal, India. He started his professional career as an Assistant Professor of this college and worked as Assistant Lecturer at Patha-Bhavana, Visva-Bharati University (a Central University), Santiniketan, West Bengal. He is a member of IQAC and the Coordinator of the environmental science of TDB College. He teaches undergraduate and postgraduate students of chemistry and also undergraduate students of biochemistry. With over ten years of teaching experience, Dr Majhi has published several research papers in national and international journals of high reputate. Dr Majhi is co-editor of Science and Technology: A Concise History and Evolution. He has also participated in various national and international conferences and symposia. His research interests focus on the isolation and structural determination of natural products, semisynthetic products, total synthesis, green chemistry, as well as biological activities of phytochemicals.