Science of Synthesis: Cross-Dehydrogenative Coupling

1. Auflage 2023
ISBN: 978-3-13-245524-5
Verlag: Thieme

Buch, Englisch, 680 Seiten, Hardback (Thread Stitching), Format (B × H): 170 mm x 255 mm, Gewicht: 1432 g

Reihe: Science of synthesis

Comprehensive overview of strategies and applications of cross-dehydrogenative coupling methodsCross-Dehydrogenative Coupling (CDC) represents a type of coupling reaction for the construction of a C-C bond or C-heteroatom (C–X) bond directly from C-H and X-H bonds present in the precursors. Since this genre of coupling reaction obviates the need for substrate prefunctionalization, it has an added advantage of high efficiency, atom economy, and environmental friendliness. CDC reactions are triggered by transition-metal catalysts or simply by an oxidants, or by either photocatalysis or electrocatalysis, leading to a hetero- or homo-coupled products with the removal of two hydrogens. Over the years, several CDC strategies have been developed that has made it possible to construct bonds between carbon-hydrogen (C–H) bonds of diverse hybridization. CDC has also streamlined the synthesis and functionalization of various nitrogen, oxygen, and sulfur-containing heterocycles. This volume features a series of chapters systematically covering methods and strategies in CDC, organized primarily on the type of bond being formed. In addition, particular aspects of CDC are highlighted in devoted chapters on topics such as mechanistic aspects, electrochemical and flow methods, transformations in water, natural product synthesis, and enantioselective protocols.

Zielgruppe

Wissenschaftler

Autoren/Hrsg.

Maiti, Debabrata

Fachgebiete

• Naturwissenschaften Chemie Organische Chemie

Inhaltsverzeichnis

1 Introduction 2 Cross-Dehydrogenative Coupling: Development and Perspectives 3 Mechanistic Aspects of Transition-Metal-Catalyzed and Non-Transition-Metal-Mediated Cross-Dehydrogenative Coupling 4 Cross-Dehydrogenative Coupling Involving Alkynes for C(sp 2 )—C(sp) Bond Formation 5 (Het)Arene/(Het)Arene Cross-Dehydrogenative Coupling for C(sp 2 )—C(sp 2 ) Bond Formation 6 (Het)Arene/Alkene Cross-Dehydrogenative Coupling for C(sp 2 )—C(sp 2 ) Bond Formation 7 Alkene/Alkene Cross-Dehydrogenative Coupling for C(sp 2 )—C(sp 2 ) Bond Formation 8 Cross-Dehydrogenative Coupling Involving Aldehydes for C(sp 2 )—C(sp 2 ) Bond Formation 9 (Het)Arene/Alkane Cross-Dehydrogenative Coupling for C(sp 2 )—C(sp 3 ) Bond Formation 10 Alkene/Alkane Cross-Dehydrogenative Coupling for C(sp 2 )—C(sp 3 ) Bond Formation 11 Cross-Dehydrogenative Coupling for C(sp 3 )—C(sp 3 ) Bond Formation 12 Electrochemical C—C Bond Formation through Cross-Dehydrogenative Coupling 13 C—C Bond Formation in Flow Systems Through Cross-Dehydrogenative Coupling 14 C—C Bond Formation in Water through Cross-Dehydrogenative Coupling 15 C—C Bond Formation through Cross-Dehydrogenative Coupling in Natural Product and API Synthesis 16 C—N Bond Formation through Cross-Dehydrogenative Coupling 17 C—O Bond Formation through Cross-Dehydrogenative Coupling 18 Heteroatom—Heteroatom Bond Formation through Cross-Dehydrogenative Coupling 19 Enantioselective Cross-Dehydrogenative Coupling