Mahyudin / Hermawan Biomaterials and Medical Devices

A Perspective from an Emerging Country
1. Auflage 2016
ISBN: 978-3-319-14845-8
Verlag: Springer International Publishing
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band 58, 249 Seiten, eBook

Reihe: Advanced Structured Materials

This book presents an introduction to biomaterials with the focus on the current development and future direction of biomaterials and medical devices research and development in Indonesia. It is the first biomaterials book written by selected academic and clinical experts experts on biomaterials and medical devices from various institutions and industries in Indonesia. It serves as a reference source for researchers starting new projects, for companies developing and marketing products and for governments setting new policies.
Chapter one covers the fundamentals of biomaterials, types of biomaterials, their structures and properties and the relationship between them. Chapter two discusses unconventional processing of biomaterials including nano-hybrid organic-inorganic biomaterials. Chapter three addresses biocompatibility issues including in vitro cytotoxicity, genotoxicity, in vitro cell models, biocompatibility data and its related failure. Chapter four describes degradable biomaterial for medical implants, which include biodegradable polymers, biodegradable metals, degradation assessment techniques and future directions. Chapter five focuses on animal models for biomaterial research, ethics, care and use, implantation study and monitoring and studies on medical implants in animals in Indonesia. Chapter six covers biomimetic bioceramics, natural-based biocomposites and the latest research on natural-based biomaterials in Indonesia. Chapter seven describes recent advances in natural biomaterial from human and animal tissue, its processing and applications. Chapter eight discusses orthopedic applications of biomaterials focusing on most common problems in Indonesia, and surgical intervention and implants. Chapter nine describes biomaterials in dentistry and their development in Indonesia.

Zielgruppe

Research

Autoren/Hrsg.

Mahyudin, Ferdyansyah

Mahyudin, Ferdiansyah

Hermawan, Hendra

Inhaltsverzeichnis

1;Preface;7
2;Contents;9
3;Editors and Contributors;10
4;1 Structure and Properties of Biomaterials;14
4.1;Abstract;14
4.2;1 Introduction;14
4.3;2 Metals;17
4.3.1;2.1 Structure and Properties;17
4.3.2;2.2 Stainless Steels;19
4.3.3;2.3 Co-Cr Alloys;20
4.3.4;2.4 Ti and Its Alloys;21
4.3.5;2.5 Other Metallic Biomaterials;21
4.4;3 Polymers;22
4.4.1;3.1 Chain Structure;23
4.4.2;3.2 Thermal and Mechanical Properties;24
4.4.3;3.3 Examples of Most Used Polymeric Biomaterials;26
4.5;4 Ceramics;27
4.5.1;4.1 Bonding and Structure;27
4.5.2;4.2 Processing and Properties of Ceramics;28
4.5.3;4.3 Type of Bioceramics and Their Use;30
4.6;5 Composites;31
4.7;6 Summary;32
4.8;Acknowledgment;32
4.9;References;33
5;2 Naturally Derived Biomaterials and Its Processing;36
5.1;Abstract;36
5.2;1 Introduction;37
5.3;2 Natural Source of Ceramic Biomaterials;38
5.3.1;2.1 Corals;38
5.3.2;2.2 Shells;39
5.4;3 Synthesis of Naturally Derived Bioceramics;40
5.4.1;3.1 Hydroxyapatite Powders;40
5.4.2;3.2 Hydroxyapatite Membranes;42
5.5;4 Other Naturally Derived Biomaterials Processes;44
5.5.1;4.1 Micro-Capsules;44
5.5.2;4.2 Bioactive Glass for Cancer Treatment;46
5.5.3;4.3 Dental Biomaterials;46
5.5.4;4.4 Surface Treatment;48
5.6;5 Perspective;50
5.7;Acknowledgment;50
5.8;References;50
6;3 Biocompatibility Issues of Biomaterials;53
6.1;Abstract;53
6.2;1 Introduction;54
6.3;2 Biocompatibility of Biomaterials;54
6.4;3 Factors and Nature of Biocompatibility;57
6.5;4 Biocompatibility of Selected Biomaterials;60
6.5.1;4.1 Amalgam;60
6.5.2;4.2 Acrylic Resin;61
6.5.3;4.3 Titanium;63
6.5.4;4.4 Bisphenol a Glycol Dimethacrylate (bis-GMA);65
6.6;5 Concept of Assessing Biocompatibility;66
6.6.1;5.1 In Vitro Test;67
6.6.2;5.2 In Vivo Test;67
6.6.3;5.3 Clinical Test;68
6.6.4;5.4 Cytotoxicity Test;68
6.7;6 Development of New Biomaterials in Indonesia;70
6.7.1;6.1 Orthopaedic Metal Plates;70
6.7.2;6.2 Bone Grafts;71
6.7.3;6.3 Ventriculoperitoneal Shunts;71
6.7.4;6.4 Bone Substitutes;72
6.8;7 Perspective;74
6.9;Acknowledgement;74
6.10;References;74
7;4 Animal Study and Pre-clinical Trials of Biomaterials;78
7.1;Abstract;78
7.2;1 Introduction;78
7.3;2 Animal Model for Biomaterials Research;79
7.3.1;2.1 Common Animal Models;79
7.3.2;2.2 Appropriate Animal Models;80
7.3.3;2.3 Target Achieving Bio-Information from Animal Models;80
7.4;3 Ethics, Care and Use of Animals;83
7.4.1;3.1 Bioethics in Biomaterials Research;83
7.4.2;3.2 Principles of “3R” (Three R Principle) and “5F” (Freedoms);83
7.4.3;3.3 Indonesian Regulations for Animal Use in Biomedical Research;86
7.4.4;3.4 Animal Ethic, Care and Use Committee;86
7.5;4 Implantation Study, Live Monitoring and Histological Analysis;87
7.5.1;4.1 Adaptation and Clinical Health Synchronization;87
7.5.2;4.2 Pre-implantation Treatments;88
7.5.3;4.3 Surgical Implantation;89
7.5.4;4.4 Post-implantation;92
7.5.5;4.5 Data Monitoring;94
7.5.6;4.6 Biomedical Imaging and Its Analysis in Life Animal;95
7.5.7;4.7 Histological Analysis;99
7.6;5 Experiences on Animal Study of Medical Implants in Indonesia;102
7.7;6 Perspective;104
7.8;Acknowledgements;104
7.9;References;104
8;5 Bioadhesion of Biomaterials;113
8.1;Abstract;113
8.2;1 Introduction;113
8.3;2 Bioadhesion: State of the Art;114
8.4;3 Aspects of Bioadhesion;117
8.4.1;3.1 Surface Topography;117
8.4.2;3.2 Chemical Interaction;118
8.4.3;3.3 Physical and Mechanical Interaction;119
8.5;4 Bioadhesion Testing;122
8.5.1;4.1 Surface Roughness Measurement;122
8.5.2;4.2 Contact Angle Measurement;123
8.5.3;4.3 Surface Topography Evaluation;125
8.5.4;4.4 Biofilm Formation Testing;125
8.6;5 Bioadhesion of Medical Devices;127
8.6.1;5.1 Polymers;127
8.6.2;5.2 Metals;128
8.6.3;5.3 Ceramics;130
8.6.4;5.4 Composites;130
8.7;6 Perspective;131
8.8;Acknowledgment;131
8.9;References;132
9;6 Degradable Biomaterials for Temporary Medical Implants;136
9.1;Abstract;136
9.2;1 Introduction;137
9.3;2 Overview on Currently Used Biomaterials;138
9.4;3 Biodegradable Polymers;140
9.4.1;3.1 Natural Biodegradable Polymers;141
9.4.2;3.2 Synthetic Biodegradable Polymers;144
9.4.3;3.3 Lesson Learned;148
9.5;4 Biodegradable Metals;149
9.5.1;4.1 Basic Concept;150
9.5.2;4.2 Degradation Assessment Techniques;153
9.5.3;4.3 Type of Biodegradable Metals;154
9.6;5 Perspective;160
9.7;Acknowledgment;160
9.8;References;161
10;7 Biomaterials in Orthopaedics;170
10.1;Abstract;170
10.2;1 Introduction;171
10.3;2 The Most Common Orthopaedic Problems in Indonesia;171
10.4;3 Surgical Intervention and Implants;174
10.4.1;3.1 Biomaterials in Orthopaedic Surgery;174
10.4.2;3.2 Types and Applications of Orthopaedic Implants;179
10.5;4 Recent Development of Orthopaedic Implants in Indonesia;185
10.5.1;4.1 The Rise of Local Implant Industry;185
10.5.2;4.2 The Challenge and Collaboration;187
10.6;Acknowledgment;188
10.7;References;188
11;8 Biomaterials in Dentistry;191
11.1;Abstract;191
11.2;1 The Importance of Oral Health and Dental Problem;191
11.3;2 The Most Common Dental Problems in Indonesia;193
11.4;3 Biomaterials in Restorative Dentistry;195
11.4.1;3.1 Preventive Materials;196
11.4.2;3.2 Operative Dentistry Materials;200
11.5;4 Recent Development on Dental Biomaterials in Indonesia;205
11.6;5 Perspective;207
11.7;Acknowledgment;208
11.8;References;208
12;9 Tissue Bank and Tissue Engineering;214
12.1;Abstract;214
12.2;1 Introduction;215
12.3;2 Natural Biomaterials;216
12.4;3 Tissue Bank;217
12.4.1;3.1 Regulation;218
12.4.2;3.2 Donors Selection;219
12.4.3;3.3 Tissue Procurement;222
12.4.4;3.4 Quarantine;223
12.4.5;3.5 Processing of the Tissue;223
12.4.6;3.6 Tissue Bank Products;225
12.4.7;3.7 Orthopaedic Applications;227
12.5;4 Tissue Engineering;229
12.5.1;4.1 The Cells;231
12.5.2;4.2 Scaffolds;233
12.5.3;4.3 Development of Tissue Engineering in Indonesia;235
12.6;Acknowledgment;237
12.7;References;237
13;10 Indonesian Perspective on Biomaterials and Medical Devices;242
13.1;Abstract;242
13.2;1 Indonesia, Facts and Figures;243
13.3;2 Challenge and Opportunity;244
13.4;3 Government Policy;245
13.4.1;3.1 Regulation;245
13.4.2;3.2 Roadmap for Medical Devices Development;246
13.5;Acknowledgment;248
13.6;References;248

From the Contents: Introduction to Biomaterials Development in Indonesia.- Structure and Properties of Biomaterials.- Unconventional Processing of Biomaterials.- Biocompatibility Issues.- Orthopedic Applications.- Biomaterials in Dentistry.