Biomaterials for Delivery and Targeting of Proteins and Nucleic Acids

1. Auflage 2004
ISBN: 978-0-8493-2334-8
Verlag: CRC Press

Buch, Englisch, 708 Seiten, Format (B × H): 156 mm x 235 mm, Gewicht: 1156 g

Newcomers to the field of biopharmaceuticals require an understanding of the basic principles and underlying methodology involved in developing protein- and nucleic acid-based therapies for genetic and acquired diseases.

Biomaterials for Delivery and Targeting of Proteins and Nucleic Acids introduces the principles of polymer science and chemistry, as well as the basic biology required for understanding how biomaterials can be used as drug-delivery vehicles. No book to date combines a discussion of high-tech biomaterials-based delivery of protein and nucleic acid drugs with the pharmaceutical or biocompatibility aspects. Featuring contributions from leading experts from around the world, this text discusses physiochemical parameters used for design, development, and evaluation of biotechnological dosage forms for delivery of proteins, peptides, oligonucleotides, and genes. The authors also present biological barriers to extravasation and cellular uptake of proteins and nucleic acids.

Combining an introduction to biomaterial delivery with the latest developments in the field, this is a valuable reference for both the novice student and the practicing scientist on delivery of biomaterials, on biomedical polymers, and on polymer therapeutics. Understanding these core fundamentals is critical to moving on to more advanced study.

Zielgruppe

Professional

Autoren/Hrsg.

Mahato, Ram I.

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie

Inhaltsverzeichnis

Structures, Properties, and Characterization of Biomaterials. Step-Reaction and Ring-Opening Polymerization. Copolymer, Block Copolymers Stimuli-Sensitive Polymers. Polymer Solution Properties, Polymer Networks, Micelles, Dendrimers, Hydrogels. Protein Conjugation, Cross-linking and PEGylation. Complement Activation by Injectable Polymeric Carriers. Biological Membranes and Barriers. Pharmacokinetics of Proteins and Nucleic Acid Drugs. In Vivo Fate of Polymeric Carriers. Subcellular Fate of sProteins and Nucleic Acids. Stability of Proteins and Nucleic Acids. Formulation, Stability and Characterization of Protein and Peptide Drugs. Micro- and Nanoparticulate Polymeric Delivery Systems for Nucleic Acid-based Medicines. Liposomal Delivery Systems of Proteins and Peptides. Mechanisms of Cellular Drug Resistance and Strategies to Overcome It. Transporters as Molecular Targets for Drug Delivery and Disposition. Protein Transduction Domains as a Novel Tool for Delivery of Protein, Peptides and Nucleic Acids. Introduction to Therapeutic Nucleic Acids. Antisense and Antigene Oligonucleotide Delivery. Artificial Nucleic Acid Chaperones. Basic Components of Plasmid-Based Gene Expression Systems. Polymeric Gene Carriers.

Über Autor(innen)

Ram I. Mahato is an assistant professor of pharmaceutics and drug delivery at the Departments of Pharmaceutical Seiences and Biomedical Engineering, University of Tennessee, Memphis.