Buch, Englisch, 136 Seiten, Format (B × H): 155 mm x 235 mm, Gewicht: 242 g
Buch, Englisch, 136 Seiten, Format (B × H): 155 mm x 235 mm, Gewicht: 242 g
Reihe: Progress in Molecular and Subcellular Biology
ISBN: 978-3-642-64117-6
Verlag: Springer
The genetic information contained in a cell needs the appropriate environment to express itself, not only the intracellular environment but also the extracel lular one. The latter is provided to a great extent by the molecules which constitute the extracellular matrix. On the one hand, the matrix creates inter alia the right pH and osmotic envi ronment and allows the diffusion of messengers targeting the cell membrane; on the other hand, it has a mechanical effect whose relevance began to be understood 28 years ago. Basically, the messages that reach the cell and are then transported to the genome depend on molecular conformational flexibility. Molecular structures usually prevail because they represent states of minimum potential energy cre ating energy barriers which are activated through conformational changes. From the periphery to the nucleus the information flows through the activa tion of energy barriers. The tools used to switch from low-energy to high energy molecular configurations are: the binding of ligands to their receptors, gradients of electrochemical potential created by ion pumps, Ca2+ mobiliza tion, and phosphorylation and dephosphorylation. Variation in molecular con figuration through molecular binding is in itself sufficient to trigger ion pumps and activate kinases and phosphatases. This is one aspect of the mechanical role of the extracellular matrix dealt with herein: the induction of molecular and supramolecular conformational modifications through interactions with the cell membrane, which promote the transduction and centripetal progression of signals.
Zielgruppe
Research
Autoren/Hrsg.
Weitere Infos & Material
Topological Constraints Carry Signaling from the Cell Matrix to the Genome.- 1 Variation in Cell Adhesion During Proliferation of Normal Cells.- 2 Coupling Between Changes in Cell Adhesion and Proliferation of Transformed Cells.- 3 Mechanisms of Cell Adhesion-Mediated Changes in the Cell Phenotype.- 4 Conclusions.- References.- The Transmission of Contractility Through Cell Adhesion.- 1 Introduction.- 2 Generation of Contractility.- 3 Molecular Mechanism of Force Transmission.- 4 Regulation of Contractility Transmission.- 5 Interaction Between Contraction Force and ECM.- 6 Myofibroblasts and Wound Healing.- 7 Muscle.- 8 Conclusion.- References.- Role of Focal Adhesion Kinase in Signaling by the Extracellular Matrix.- 1 Introduction.- 2 FAK Activation by Integrin.- 3 FAK Downstream Pathways.- 4 Biological Functions of FAK in Signaling by ECM.- References.- Interaction Between Cells and Extracellular Matrix: Signaling by Integrins and the Elastin-Laminin Receptor.- 1 Introduction.- 2 Cell-Matrix Interactions Mediated by Integrins.- 3 Cell-Matrix Interactions Mediated by the Elastin-Laminin Receptor.- 4 Discussion and Conclusions.- References.- Regulation of Gene Expression by Changes in Cell Adhesion.- 1 Introduction.- 2 Regulation of Cell Proliferation by Cell Adhesion.- 3 Regulation of Cell Differentiation by Cell Adhesion.- 4 Conclusion.- References.- Expression of Liver Specific-Genes in Hepatocytes Cultured in Collagen Gel Matr.- 1 Introduction.- 2 Culture of Hepatocytes in Collagen Gel.- 3 Hepatic Specific Functions of Hepatocytes in Collagen Cultures.- 4 Biotransformation Capability: Basal and Induced Levels of Drug-Metabolizing Enzymes.- 5 Expression of Hepatic Transcription Factors.- 6 Concluding Remarks.- References.- Collagen Type I: A Substrate and a Signal for Invasion.- 1 Introduction.- 2 Invasion into Matrices.- 3 Effects of Collagen on the Invasive Behavior of Cells.- 4 A Scenario for the Molecular Cross Talk Between Collagen and Cell.- 5 Conclusion.- References.
