Carbonyl Reductase

Design, Screening, Modification and Industrial Applications
Erscheinungsjahr 2025
ISBN: 978-0-443-32860-2
Verlag: Elsevier Science

Buch, Englisch, 400 Seiten, Format (B × H): 191 mm x 235 mm

Carbonyl Reductase: Design, Screening, Modification and Industrial Applications promotes the practical applications of carbonyl reductase. This book introduces the most recent advances of carbonyl reductases, including the analyzed crystal structures and structural information, the catalytic mechanism, the high-throughput screening methods, the protein engineering and the expanded applications. This book is a valuable resource for researchers and professionals interested in carbonyl reductase and chiral ?-amino alcohols production.

Autoren/Hrsg.

Liu, Zhi-Qiang

Fachgebiete

• Naturwissenschaften Biowissenschaften Molekularbiologie
• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)

Inhaltsverzeichnis

Section 1 Discovery and Classification of Carbonyl Reductases
1. Discovery of carbonyl reductases
2. Classification of carbonyl reductases

Section 2 Molecular Basics of Carbonyl Reductase
3. Stereoselectivity Catalytic Mechanism of Carbonyl Reductase
4. Design and Molecular Modification of Carbonyl Reductase

Section 3 Coenzyme Systems
5. Coenzyme Regeneration in Carbonyl Reduction Reaction

Section 4 Application of Stereoselectivity Carbonyl Reductase in the Synthesis of Chiral Alcohol Pharmaceutical Intermediates
6. Applications in Hypolipidemic Drugs
7. Applications in Carbapenem Antibiotics
8. Applications in Depression Treatment Drugs
9. Applications in Anti-asthma Drugs
10. Applications in Antihypertensive Drugs
11. Applications in Anticoagulant Drugs
12. Applications in Antiepileptic Drugs
13. Applications in Non-Steroidal Anti-Inflammatory Drugs
14. Applications in Anticancer Drugs
15. Applications in anti-aids Drugs
16. Applications in Adrenoceptor Agonists

Sections 5 Application of carbonyl reductases in the synthesis of other fine chemicals
17. Chirality ?- Pentolactone
18. (2S, 3S) -2,3-butanediol
19. Phenylethanol

Über Autor(innen)

Liu, Zhi-Qiang
Dr Liu Zhi-Qiang has been working for more than 20 years in industrialization of biomanufacturing. Dr Zhi-Qiang's expertise lies in conducting cutting-edge research and technological advancements across the entire innovation chain, encompassing the discovery and design of functional proteins, the editing and reconstruction of artificial cells, and the control and integrated amplification of biotransformation processes. With a focus on optimizing enzymes for non-natural environments and unraveling the intricate regulation and coordination mechanisms of metabolic pathways, the applicant has made remarkable contributions to the field. They have successfully led numerous research projects, including the prestigious Zhejiang Provincial Key Research and Development Plan, and have published more than 100 articles in top-tier international journals. Their innovative work has resulted more than 70 authorized Chinese invention patents, 45 implementation of patented technologies in various enterprises, and the establishment of over 10 industrial production lines.