Litwack Vitamins and Hormones

1. Auflage 1995
ISBN: 978-0-08-086648-2
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band Volume 51, 468 Seiten, Web PDF

Reihe: Vitamins and Hormones

General Description of Volume:Volume 51 includes reviews papers on cyclic AMP, kinases, polypeptide hormones, steroid hormone receptors, related genes, and members of the gene family. General Description of Series:Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish up-to-date synthetic reviews of interest to endocrinologists and biochemists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. In the early days of the serial, the subjects of vitamins and hormones were quite distinct. Now, new discoveries have proved that several of the vitamins function as hormones and many of the substances inferred by the title of the Serial function in signal transduction processes. Accordingly, the editor-in-chief has expanded the scope of the serial to reflect this newer understanding of function-structure relationships in cellular communication. The newly modified editorial board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology and enzyme mechanisms. Vitamins and Hormones continues to publish up-to-date synthetic reviews of interest to endocrinologists and biochemists. Others will increasingly turn to this series for comprehensive reviews by leading researchers in this and related disciplines.

Autoren/Hrsg.

Litwack, Gerald

Inhaltsverzeichnis

1;Front Cover;1
2;Vitamins and Hormones: Advances in Research and Applications, Volume 51;4
3;Copyright Page;5
4;Contents;8
5;Preface;12
6;Chapter 1. cAMP-Dependent Regulation of Gene Transcription by cAMP Response Element-Binding Protein and cAMP Response Element Modulator;14
6.1;I. Introduction;15
6.2;II. cAMP-Dependent Signal Transduction Pathway;15
6.3;III. camp-Responsive Transcription Factors CREB,CREM and ATF-1;19
6.4;IV. cAMP Response Elements;21
6.5;V. Mechanisms of Transciptional Transactivation;25
6.6;VI. The CREB and CREM Genes Are Multiexonic in Structure: Alternative Exon Splicing Generates a Complex Array of Isoproteins That Are Either Transactivators or Transrepressors;34
6.7;VII. cAMP-Dependent Autoregulation of the Expression of the CREB and CREM Genes;44
6.8;VIII. Roles of CREB and CREM in the Physiological Regulation of Gene Transcription;45
6.9;IX. CREB/CREM Autoregulatiom Network;53
6.10;X. Oncogenic Forms of CREB, CREM, and ATF-1;55
6.11;XI. Future Directions;56
6.12;References;59
7;Chapter 2. Multiple Facets of the Modulation of Growth by c72
7.1;I. Introduction;72
7.2;II. Negative Control of Cell Cycle Progression by c86
7.3;III. Positive Control of Cell Cycle Progression by c96
7.4;IV. Relationship between Growth and Differentiation Controls by c131
7.5;V. A Role for Cytoskeleton Changes in Control of Growth by cAMP?;135
7.6;VI. cAMP and the Growth of Cancer cell;140
7.7;VII. Conclusions and Perspectives;153
7.8;References;157
8;Chapter 3. Regulation of G Protein-Coupled Receptors by Receptor Kinases and Arrestins ;206
8.1;I. Introduction;206
8.2;II. GRKs;209
8.3;III. Arrestins;226
8.4;IV. Conclusions;239
8.5;References;240
9;Chapter 4. Vasopressin and Oxytocin: Molecular Biology and Evolution of the Peptide Hormones and Their Receptors;248
9.1;I. Introduction;248
9.2;II. VP and OT Gene Expression and Regulation;250
9.3;III. VP and OT mRNA in Dendrites and Axons;255
9.4;IV. Somatic Recombination between the VP and OT Genes in Hypothalamic Neurons ;260
9.5;V. Evolution of the Vertebrate VP/OT Gene Family;262
9.6;VI. Nonapeptide Receptors;264
9.7;References;271
10;Chapter 5. Structure and Function of Strogen Receptors;280
10.1;I. Introduction;280
10.2;II. Physiological Responses to Estrogens;281
10.3;III. Intracellular Localization of Estrogen Receptors;285
10.4;IV. Hormone Binding and Receptor Dimerization;285
10.5;V. Target Gene Recognition;287
10.6;VI. Transcriptional Activation;288
10.7;VII. Specific Gene Transcription by the Estrogen Receptor;289
10.8;VIII. Mechanism of Antiestrogen Action;302
10.9;IX. Cross-coupling with Other Signaling Pathways;293
10.10;References;295
11;Chapter 6. Phosphorylation and Steroid Hormone Action ;302
11.1;I. Introduction;302
11.2;II. Phosphorylation of Steroid Hormone Receptors;303
11.3;III. Regulation of Steroid Hormone Receptors by Phosphorylation;309
11.4;IV. Interaction between Steroid Hormone Action and Signal Transduction Pathways;314
11.5;V. Summary: A Model of Steroid Hormone Action;318
11.6;References;320
12;Chapter 7.Nucleocytoplasmic Shuttling of Steroid Receptors ;328
12.1;I. Introduction;328
12.2;II. Subcellular Localization of Steroid Receptors;329
12.3;III. Nucleocytoplasmic Shuttling of Steroid Receptors;336
12.4;References;346
13;Chapter 8. Transcriptional Regulation of the Genes Encoding the Cytochrome P-450 Steroid Hydroxylases ;352
13.1;I. Introduction;352
13.2;II. Overview of Steroid Hormone Biosynthesis;353
13.3;III. Cell-Selective Expression;360
13.4;IV. Hormone-Regulated Expression;368
13.5;V. Perspectives and Future Directions;373
13.6;VI. Summary;375
13.7;References;376
14;Chapter 9. Stress and the Brain: A Paradoxical Role for Adrenal Steroids;384
14.1;I. Introduction;384
14.2;II. Adrenal Steroids and Hippocampal Neuronal Atrophy;387
14.3;III. Antidepressants Modify Stress-Induced Changes in the Hippocampus;390
14.4;IV. Paradoxical Effects of Adrenal Steroids in the Hippocampus;393
14.5;V. Role of Adrenal Steroid Receptor Subtypes in Structural and Neurochemical Plasticity ;400
14.6;VI. Other Actions of Adrenal Steroids Fklated to Neuronal Atrophy;401
14.7;VII. Stress Effects on Cognitive Performance in Rodents;404
14.8;VIII. Deregulation of the HPA Axis in Depression and Other Disorders;406
14.9;IX. Effects of Exogenous Glucocorticoid Treatment on Cognitive Performance in Humans;407
14.10;X. Conclusions;408
14.11;References;409
15;Chapter 10. Retinoids and Mouse Embryonic Development ;416
15.1;I. Introduction;416
15.2;II. Retinoid Receptors;418
15.3;III. Retinoid-Binding Proteins;435
15.4;IV. Retinoid Receptor Expression Patterns and Genetic Analysis of Function;440
15.5;V. Conclusions and Perspectives;449
15.6;References;455
16;Index;472