Litwack Vitamins and Hormones

1. Auflage 2002
ISBN: 978-0-08-052286-9
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band Volume 64, 416 Seiten, Web PDF

Reihe: Vitamins and Hormones

First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. In the early days of the Serial, the subjects of vitamins and hormones were quite distinct. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines. - Vitamins are organic substances not naturally produced by the body that are necessary in trace amounts for normal physiologic and metabolic functioning. Hormones are biochemical substances produced in cells and tissues that cause a specific biological change or activity to occur elsewhere in the body - Study of both vitamins and hormones is essential to our understanding of physiology

Autoren/Hrsg.

Litwack, Gerald

Inhaltsverzeichnis

1;Cover;1
2;Contents;8
3;Preface;12
4;Chapter 1. Embryonic Stem Cells Provide a Powerful and Versatile Model System;14
4.1;I. Introduction;15
4.2;II. Characteristics of ES Cells and Their Close Relatives, EC Cells and EG Cells;16
4.3;III. Isolation and Cultivation of ES Cells and EG Cells;19
4.4;IV. In Vitro Differentiation of ES Cells;24
4.5;V. ES and EC Cells: Powerful Model Systems for Studying Gene Expression;33
4.6;VI. Future Perspectives;41
4.7;References;46
5;Chapter 2. Molecules in Blastocyst Implantation: Uterine and Embryonic Perspectives;56
5.1;I. Introduction;57
5.2;II. Embryo–Uterine Interactions;59
5.3;III. Uterine Factors in Implantation ;64
5.4;IV. Embryonic Factors in Implantation;73
5.5;V. Uterine Markers in Humans;78
5.6;VI. Conclusion;79
5.7;References;81
6;Chapter 3. Microarray Analysis of B-Cell Stimulation;90
6.1;I. Introduction;91
6.2;II. Materials and Methods;92
6.3;III. Results and Discussion;94
6.4;IV. Conclusions;107
6.5;References;107
7;Chapter 4. Tissue Culture Models for Studies of Hormone and Vitamin Action in Bone Cells;114
7.1;I. Introduction;115
7.2;II. The Skeleton;116
7.3;III. Bone Remodeling;116
7.4;IV. Hormonal Regulation of Bone Remodeling;118
7.5;V. Osteoclast Biology;122
7.6;VI. Tissue Culture Models for the Study of Osteoclasts;123
7.7;VII. Osteoblast Biology;130
7.8;VIII. Tissue Culture Models for the Study of Osteoblasts;132
7.9;IX. Closing Remarks;153
7.10;References;153
8;Chapter 5. Transport of Leukotriene C4 and Structurally Related Conjugates;166
8.1;I. Introduction;167
8.2;II. ATP-Dependent Biosynthetic Release of Leukotriene C4;168
8.3;III. Hepatobiliary Elimination of Cysteinyl Leukotrienes;183
8.4;IV. Conclusions;187
8.5;References;188
9;Chapter 6. Interleukin-1ß Exerts a Myriad of Effects in the Brain and in Particular in the Hippocampus: Analysis of Some of These Actions;198
9.1;I. Introduction;199
9.2;II. The IL-1 Superfamily and Associated Receptors;199
9.3;III. IL-1 and the CNS;202
9.4;IV. Effect of IL-1ß in the Hippocampus;208
9.5;V. What Mediators Are Utilized by IL-1ß?;221
9.6;VI. Conclusions;221
9.7;References;222
10;Chapter 7. Leptin and Sweet Taste;234
10.1;I. Introduction;235
10.2;II. Genetic Approaches to Taste Receptor Mechanisms;237
10.3;III. Sweet Taste Responses in db/db Mice;239
10.4;IV. Leptin as a Modulator of Sweet Taste Responses;241
10.5;V. Intracellular Mechanisms for Leptin Modulation of Sweet Taste Responses;245
10.6;VI. Leptin Effects on Regulation of Food Intake through Modulation of Sweet Sensitivities;249
10.7;VII. Conclusion;254
10.8;References;255
11;Chapter 8. Molecular, Structural, and Cellular Biology of Follitropin and Follitropin Receptor;262
11.1;I. Background and Nomenclature;263
11.2;II. Molecular Genetics of Human Follitropin;264
11.3;III. Regulation of Follitropin Protein Levels;266
11.4;IV. General Features of Follitropin Deduced from cDNA;270
11.5;V. Structural Biology of Follitropin;276
11.6;VI. Molecular Genetics of Follitropin Receptor;281
11.7;VII. General Features of Follitropin Receptor Deduced from cDNA;290
11.8;VIII. Follitropin Receptor Structure and Function Correlates;297
11.9;IX. Follitropin Receptor Signal Transduction;304
11.10;X. Summary and Conclusions;314
11.11;References;315
12;Chapter 9. Factor VIIa/Tissue Factor-Induced Signaling: A Link between Clotting and Disease;336
12.1;I. Coagulation System;337
12.2;II. Nonhemostatic Functions of Tissue Factor and Factor VIIa;338
12.3;III. Potential Mechanisms by Which VIIa/Tissue Factor Regulates Biological Functions;344
12.4;IV. Physiological Significance of VIIa/Tissue Factor-Induced Signaling;359
12.5;V. Summary;363
12.6;References;363
13;Chapter 10. Antiproliferative Action of Vitamin D;370
13.1;I. Introduction;371
13.2;II. The General Mechanism of Vitamin D Action;372
13.3;III. Antiproliferative Effects of Vitamin D on Cell Growth;379
13.4;IV. The Role of Vitamin D Crosstalk in Growth Factor and Hormone Signaling;389
13.5;V. Vitamin D and Cancer;395
13.6;VI. Conclusions and Future Perspectives;400
13.7;References;401
14;Index;420