Surface-Enhanced Raman Spectroscopy for Cancer Diagnostics

Fundamental Principles and Applications
Erscheinungsjahr 2026
ISBN: 978-0-443-40411-5
Verlag: Elsevier Science

Buch, Englisch, 520 Seiten, Format (B × H): 191 mm x 235 mm, Gewicht: 449 g

Surface-Enhanced Raman Spectroscopy for Cancer Diagnostics: Fundamental Principles and Applications bridges the gap between theory and practice, offering a detailed overview of surface-enhanced Raman spectroscopy (SERS) principles and its use in detecting cancer biomarkers. Starting with the basics of Raman spectroscopy and SERS, the book explores the relevance, design strategies, and applications of SERS in early cancer detection and treatment. It highlights the impact of nanotechnology on SERS, including the development of substrates and nanoprobes for both label-free and labeled detection. The following chapters discuss SERS immunoassays, imaging, and spectroscopic technologies for detecting cancer biomarkers. The book also explores non-invasive detection methods, multimodal imaging techniques, and the integration of artificial intelligence in SERS for test analysis. This book is a valuable resource for researchers interested on the application of nanotechnologies in the field of cancer diagnostics and treatment.

Autoren/Hrsg.

Lin, Linley Li

Bhaskar, Seemesh

Bonyár, Attila

Rouxel, Didier

Thomas, Sabu

Fachgebiete

• Technische Wissenschaften Maschinenbau | Werkstoffkunde Technische Mechanik | Werkstoffkunde

Inhaltsverzeichnis

1. Introduction to Raman Spectroscopy and Surface-Enhanced Raman Spectroscopy (SERS)
2. SERS: Relevance, Design Strategies and Applications
3. Cancer: relevance of early diagnostics and treatment
4. Role of Nanotechnology in Cancer Diagnostics
5. Advancement of Nanotechnology in SERS developments: substrates and nanoprobes for label-free and labelled detection
6. SERS Immunoassays: Principles and design strategies
7. SERS-based imaging and spectroscopic technologies for cancer biomarker detection
8. SERS for pathogen detection
9. SERS-based Detection of non-invasive Cancer Biomarker: sweat, saliva, sputum, urine, and volatile organic compounds (VOCs)
10. SERS-based Detection of invasive Cancer Biomarker: nucleic acids, proteins, lipids, metabolites
11. SERS needle patch for skin cancer diagnosis
12. SERS-based Multimodal Imaging Techniques
13. SERS for intraoperative surgery guidance and tumor boundary detection
14. Deep SERS imaging technologies for non-invasive lesion diagnostics
15. Artificial Intelligence for SERS: advances in Point-of-Care test analysis
16. SERS for cancer diagnostics in clinical samples: Challenges and opportunities
17. Emerging Trends in SERS Instrumentation and Signal Enhancement Techniques
18. Biocompatibility and Biosafety Considerations in SERS Probe Design
19. Tumor detection, Cancer screening, Diagnostics assays
20. Concluding remarks: Clinical Translation and Regulatory Considerations of SERS for cancer diagnostics

Über Autor(innen)

Bhaskar, Seemesh
Dr. Seemesh Bhaskar is a Carl R. Woese Institute for Genomic Biology (IGB) fellow at the University of Illinois at Urbana-Champaign (UIUC), USA. He completed his Ph.D. from STAR Lab, Central Research Instruments Facility (CRIF), SSSIHL, and postdoctoral studies from NanoStructured Materials (NSM) group, Indian Institute of Technology (IIT), Bombay. He has pursued research internships at SASTRA University and the Indian Institute of Science, Bangalore, as part of the DST-Inspire program. He is the recipient of the prestigious DST-Inspire scholarship & fellowship, AWSAR, K. V. Rao Scientific Society (KVRSS), Young Achiever, M.Sc. Chemistry Gold medal and All-rounder Gold medal awards. His research work focuses on building effective nano-engineering protocols for photo-plasmonic biosensing at advanced interfaces comprising sustainable bioinspired polymeric hybrids.

Lin, Linley Li
Dr. Linley Li Lin is currently an Assistant Professor at Shanghai Jiao Tong University (SJTU), China. She received her B.S. and Ph.D. degrees from SJTU and worked as a postdoctoral fellow at the University of Illinois at Urbana-Champaign, USA, and SJTU. During her PhD and Postdoctoral research, she was one of the principal researchers of GERTs - a novel SERS nanotag with ultra-high sensitivity, uniformity, and photostability. Her current research interests include deep Raman techniques, surface-enhanced Raman scattering bioimaging, and Raman spectroscopic platform to study biomaterial interfaces.

Bonyár, Attila
Dr. Attila Bonyár is an associate professor and head of the Nanotechnology laboratory at the Department of Electronics Technology, Faculty of Electronics Engineering and Informatics, Budapest University of Technology and Economics, Hungary. He has two M.Sc. degrees in electrical engineering (2009) and biomedical engineering (2011), a Ph.D. (2014), and habilitation (2021) in electrical engineering. His current research activities are focused on the development of optical biosensor technologies utilizing plasmonics, low-dimensional nanomaterials, nanocomposites and nanometrology. He was elected to serve in the Hungarian Academy of Sciences (HAS) Electron Devices and Electronics Technology Scientific Committee for two terms (in 2017 and in 2021). He is the chair for IEEE NTC Nanopackaging Technical Committee (since 2022, co-chair since 2020) and actively serves in many other international committees in elected/volunteer positions.

Thomas, Sabu
Sabu Thomas is a Professor and Director of the International and Interuniversity Centre for Nanoscience and Nanotechnology, Mahatma Gandhi University, Kerala, India. Professor Thomas is internationally recognized for his contributions to polymer science and engineering, with his research interests encompassing polymer nanocomposites, elastomers, polymer blends, interpenetrating polymer networks, polymer membranes, green composites, nanocomposites, nanomedicine, and green nanotechnology. His groundbreaking inventions in polymer nanocomposites, polymer blends, green bionanotechnology, and nano-biomedical sciences have significantly advanced the development of new materials for the automotive, space, housing, and biomedical fields.